Cardiac Resynchronization The Influence of Left Ventricular Ejection Fraction on the Effectiveness of Cardiac Resynchronization Therapy MADIT-CRT ( Multicenter Automatic Defibrillator Implantation Trial With Cardiac Resynchronization Therapy )

Methods In the MADIT-CRT (Multicenter Automatic Defibrillator Implantation Trial With Cardiac Resynchronization Therapy) study, the echocardiography core laboratory assessed baseline LVEF independent of the enrolling centers and identified a range of LVEFs, including those 30% (i.e., beyond the eligibility criteria). Echocardiographic response with CRT, defined as percent change in left ventricular end-diastolic volume (LVEDV), was analyzed in 3 prespecified LVEF groups: 30%, 26% to 30%, and 25%. The primary endpoint was HF or death. Secondary endpoint included all-cause mortality.

[1]  J. Sanderson,et al.  Cardiac Resynchronization Therapy in Patients with Mildly Impaired Left Ventricular Function , 2009, Pacing and clinical electrophysiology : PACE.

[2]  C. Klersy,et al.  Remission of left ventricular systolic dysfunction and of heart failure symptoms after cardiac resynchronization therapy: temporal pattern and clinical predictors. , 2008, American heart journal.

[3]  A. Moss,et al.  Prognosis after myocardial infarction. , 1983, The American journal of cardiology.

[4]  John L Sapp,et al.  Cardiac-resynchronization therapy for mild-to-moderate heart failure. , 2010, The New England journal of medicine.

[5]  Claudia Stöllberger,et al.  Guidelines for device-based therapy of cardiac rhythm abnormalities. , 2009, Heart rhythm.

[6]  D. DeMets,et al.  Cardiac-resynchronization therapy with or without an implantable defibrillator in advanced chronic heart failure. , 2004, The New England journal of medicine.

[7]  Richard B Devereux,et al.  Recommendations for chamber quantification: a report from the American Society of Echocardiography's Guidelines and Standards Committee and the Chamber Quantification Writing Group, developed in conjunction with the European Association of Echocardiography, a branch of the European Society of Cardio , 2005, Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography.

[8]  M. Gold,et al.  Prevention of disease progression by cardiac resynchronization therapy in patients with asymptomatic or mildly symptomatic left ventricular dysfunction: insights from the European cohort of the REVERSE (Resynchronization Reverses Remodeling in Systolic Left Ventricular Dysfunction) trial. , 2009, Journal of the American College of Cardiology.

[9]  M. Cheitlin.  Relationship between improvement in left ventricular dyssynchrony and contractile function and clinical outcome with cardiac resynchronization therapy: the MADIT-CRT trial , 2012 .

[10]  A J Moss,et al.  Implantable cardioverter defibrillator therapy: the sickest patients benefit the most. , 2000, Circulation.

[11]  H. Wellens,et al.  Out-of-hospital cardiac arrest--the relevance of heart failure. The Maastricht Circulatory Arrest Registry. , 2003, European heart journal.

[12]  Karl Swedberg,et al.  Influence of Ejection Fraction on Cardiovascular Outcomes in a Broad Spectrum of Heart Failure Patients , 2005, Circulation.

[13]  Cheuk-Man Yu,et al.  Effect of Cardiac Resynchronization Therapy in Patients with Moderate Left Ventricular Systolic Dysfunction and Wide QRS Complex: A Prospective Study , 2006, Journal of cardiovascular electrophysiology.

[14]  J. Bax,et al.  Cardiac resynchronization therapy may benefit patients with left ventricular ejection fraction >35%: a PROSPECT trial substudy , 2010, European journal of heart failure.

[15]  J. Daubert,et al.  The effect of cardiac resynchronization on morbidity and mortality in heart failure. , 2005, The New England journal of medicine.

[16]  Stefano Ghio,et al.  Randomized trial of cardiac resynchronization in mildly symptomatic heart failure patients and in asymptomatic patients with left ventricular dysfunction and previous heart failure symptoms. , 2008, Journal of the American College of Cardiology.

[17]  Wojciech Zareba,et al.  Cardiac-resynchronization therapy for the prevention of heart-failure events. , 2009, The New England journal of medicine.

[18]  Milton Packer,et al.  Cardiac resynchronization in chronic heart failure. , 2002, The New England journal of medicine.

[19]  S. Solomon,et al.  Effect of Cardiac Resynchronization Therapy on Reverse Remodeling and Relation to Outcome: Multicenter Automatic Defibrillator Implantation Trial: Cardiac Resynchronization Therapy , 2010, Circulation.

[20]  Wojciech Zareba,et al.  Multicenter Automatic Defibrillator Implantation Trial–Cardiac Resynchronization Therapy (MADIT‐CRT): Design and Clinical Protocol , 2005, Annals of noninvasive electrocardiology : the official journal of the International Society for Holter and Noninvasive Electrocardiology, Inc.

[21]  Paul J. Wang,et al.  Effectiveness of Cardiac Resynchronization Therapy by QRS Morphology in the Multicenter Automatic Defibrillator Implantation Trial–Cardiac Resynchronization Therapy (MADIT-CRT) , 2011, Circulation.

[22]  陈涵.  ACC/AHA/HRS 发布新版成人室上性心动过速指南 , 2015 .