Phenylbutyric acid robustly increases Npy mRNA expression in hypothalamic neurons by increasing H3K9/14 acetylation at the Npy promoter.

[1]  Jim T. C. Chen,et al.  Palmitate‐mediated induction of neuropeptide Y expression occurs through intracellular metabolites and not direct exposure to proinflammatory cytokines , 2021, Journal of neurochemistry.

[2]  Kamila M Cass,et al.  A Comprehensive Review of Complications and New Findings Associated with Anorexia Nervosa , 2021, Journal of clinical medicine.

[3]  H. Krishnan,et al.  CB1 receptor neutral antagonist treatment epigenetically increases neuropeptide Y expression and decreases alcohol drinking , 2021, Neuropharmacology.

[4]  S. Chien,et al.  Maintenance of HDACs and H3K9me3 Prevents Arterial Flow-Induced Venous Endothelial Damage , 2021, Frontiers in Cell and Developmental Biology.

[5]  A. Dutkiewicz,et al.  Neuropeptide Y and Peptide YY in Association with Depressive Symptoms and Eating Behaviours in Adolescents across the Weight Spectrum: From Anorexia Nervosa to Obesity , 2021, Nutrients.

[6]  Nagalakshmi Balasubramanian,et al.  Role for Histone Deacetylation in Traumatic Brain Injury-Induced Deficits in Neuropeptide Y in Arcuate Nucleus: Possible Implications in Feeding Behavior , 2020, Neuroendocrinology.

[7]  D. Belsham,et al.  BPA differentially regulates NPY expression in hypothalamic neurons through a mechanism involving oxidative stress. , 2020, Endocrinology.

[8]  Jing Qu,et al.  Protein acetylation and deacetylation: An important regulatory modification in gene transcription (Review) , 2020, Experimental and therapeutic medicine.

[9]  D. Belsham,et al.  Bisphenol A Induces Agrp Gene Expression in Hypothalamic Neurons through a Mechanism Involving ATF3 , 2020, Neuroendocrinology.

[10]  Jeong-Sun Kim,et al.  A short guide to histone deacetylases including recent progress on class II enzymes , 2020, Experimental & Molecular Medicine.

[11]  R. Sirianni,et al.  Targeting Small Molecule Delivery to the Brain and Spinal Cord via Intranasal Administration of Rabies Virus Glycoprotein (RVG29)-Modified PLGA Nanoparticles , 2020, Pharmaceutics.

[12]  R. Moreau,et al.  Lipid-regulating properties of butyric acid and 4-phenylbutyric acid: Molecular mechanisms and therapeutic applications. , 2019, Pharmacological research.

[13]  F. Ebling,et al.  Effect of sodium 4-phenylbutyrate on Clenbuterol-mediated muscle growth , 2018, PloS one.

[14]  Kai Wang,et al.  3C and 3C-based techniques: the powerful tools for spatial genome organization deciphering , 2018, Molecular Cytogenetics.

[15]  J. Worthington,et al.  The potential role of the novel hypothalamic neuropeptides nesfatin-1, phoenixin, spexin and kisspeptin in the pathogenesis of anxiety and anorexia nervosa , 2018, Neurochemistry International.

[16]  Jian Zhang,et al.  Zinc binding groups for histone deacetylase inhibitors , 2018, Journal of enzyme inhibition and medicinal chemistry.

[17]  C. Paiva,et al.  Impact of chemotherapy on perceptions related to food intake in women with breast cancer: A prospective study , 2017, PloS one.

[18]  L. Nguyen,et al.  Maternal high-fat diet induces metabolic stress response disorders in offspring hypothalamus. , 2017, Journal of molecular endocrinology.

[19]  K. Timper,et al.  Hypothalamic circuits regulating appetite and energy homeostasis: pathways to obesity , 2017, Disease Models & Mechanisms.

[20]  S. Luquet,et al.  High fat induces acute and chronic inflammation in the hypothalamus: effect of high-fat diet, palmitate and TNF-α on appetite-regulating NPY neurons , 2017, International Journal of Obesity.

[21]  D. Putt,et al.  The link between hypothalamic epigenetic modifications and long-term feeding control , 2016, Appetite.

[22]  M. Cline,et al.  Promotion of adipogenesis by neuropeptide Y during the later stages of chicken preadipocyte differentiation , 2016, Physiological reports.

[23]  Brian Finan,et al.  Hypothalamic leptin action is mediated by histone deacetylase 5 , 2016, Nature Communications.

[24]  D. Cassio,et al.  Targeted pharmacotherapy in progressive familial intrahepatic cholestasis type 2: Evidence for improvement of cholestasis with 4‐phenylbutyrate , 2015, Hepatology.

[25]  Hong Ping Chen,et al.  Histone deacetylases and mechanisms of regulation of gene expression. , 2015, Critical reviews in oncogenesis.

[26]  S. Dedeurwaerdere,et al.  Long-Term Valproate Treatment Increases Brain Neuropeptide Y Expression and Decreases Seizure Expression in a Genetic Rat Model of Absence Epilepsy , 2013, PloS one.

[27]  M. Mannervik,et al.  Allele-specific programming of Npy and epigenetic effects of physical activity in a genetic model of depression , 2013, Translational Psychiatry.

[28]  Ghazala Begum,et al.  Epigenetic changes in fetal hypothalamic energy regulating pathways are associated with maternal undernutrition and twinning , 2012, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[29]  J. Tao,et al.  Growth inhibitory effect of 4-phenyl butyric acid on human gastric cancer cells is associated with cell cycle arrest. , 2012, World journal of gastroenterology.

[30]  A. Sakharkar,et al.  Histone deacetylases (HDAC)-induced histone modifications in the amygdala: a role in rapid tolerance to the anxiolytic effects of ethanol. , 2012, Alcoholism, clinical and experimental research.

[31]  D. Belsham,et al.  Cellular leptin resistance impairs the leptin-mediated suppression of neuropeptide Y secretion in hypothalamic neurons. , 2011, Endocrinology.

[32]  A. Yoshimura,et al.  Neuronal suppressor of cytokine signaling-3 deficiency enhances hypothalamic leptin-dependent phosphatidylinositol 3-kinase signaling. , 2011, American journal of physiology. Regulatory, integrative and comparative physiology.

[33]  Hiromasa Funato,et al.  Fasting and High-Fat Diet Alter Histone Deacetylase Expression in the Medial Hypothalamus , 2011, PloS one.

[34]  D. Drucker,et al.  Ciliary neurotrophic factor recruitment of glucagon‐like peptide‐1 mediates neurogenesis, allowing immortalization of adult murine hypothalamic neurons , 2009, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[35]  J. Workman,et al.  Introducing the acetylome , 2009, Nature Biotechnology.

[36]  Jason Chung,et al.  Endoplasmic reticulum stress plays a central role in development of leptin resistance. , 2009, Cell metabolism.

[37]  E. Olson,et al.  The many roles of histone deacetylases in development and physiology: implications for disease and therapy , 2009, Nature Reviews Genetics.

[38]  D. Schrenk,et al.  Inhibition of histone-deacetylase activity by short-chain fatty acids and some polyphenol metabolites formed in the colon. , 2008, The Journal of nutritional biochemistry.

[39]  F. Feng,et al.  Phenylbutyrate sensitizes human glioblastoma cells lacking wild-type p53 function to ionizing radiation. , 2007, International journal of radiation oncology, biology, physics.

[40]  A. Lagrange Valproate Enhances Neuropeptide Y Expression: Modulating the Modulators , 2007, Epilepsy currents.

[41]  Karl-Eric Magnusson,et al.  Effects of Histone Deacetylase Inhibitors, Sodium Phenyl Butyrate and Vitamin B3, in Combination with Retinoic Acid on Granulocytic Differentiation of Human Promyelocytic Leukemia HL‐60 Cells , 2006, Annals of the New York Academy of Sciences.

[42]  D. Belsham,et al.  Coordinate regulation of neuropeptide Y and agouti-related peptide gene expression by estrogen depends on the ratio of estrogen receptor (ER) alpha to ERbeta in clonal hypothalamic neurons. , 2006, Molecular endocrinology.

[43]  Min-Seon Kim,et al.  Role of hypothalamic Foxo1 in the regulation of food intake and energy homeostasis , 2006, Nature Neuroscience.

[44]  L. Verdone,et al.  Role of histone acetylation in the control of gene expression. , 2005, Biochemistry and cell biology = Biochimie et biologie cellulaire.

[45]  C. Benz,et al.  Clinical development of histone deacetylase inhibitors as anticancer agents. , 2005, Annual review of pharmacology and toxicology.

[46]  D. Belsham,et al.  Generation of a phenotypic array of hypothalamic neuronal cell models to study complex neuroendocrine disorders. , 2004, Endocrinology.