Early‐onset Alzheimer's disease

Follow-up observations were made of 92 white patients with early-onset Alzheimer's disease to determine the demographic, clinical, and neuropsychological factors predictive of institutionalization or death. The cumulative mortality rate 5 years after entry into the study was 23.9%, compared with an expected rate of 9.5%. The 5-year cumulative rate of admission to nursing homes was 62.8%. The language ability of the patients on entry to the study, their scores on a brief screening test of cognitive function, and their overall ratings of clinical dementia were found to be predictors of subsequent institutional care and death. The age of the patients had a significant modifying effect on these predictive factors, resulting in a greater risk of institutionalization and death in younger patients with severe cognitive impairment as compared with older individuals with the same degree of dysfunction.

[1]  W. Hauser,et al.  Seizures and myoclonus in patients with Alzheimer's disease , 1986, Neurology.

[2]  L. George,et al.  Predictors of Institutionalization Among Caregivers of Patients With Alzheimer's Disease , 1986, Journal of the American Geriatrics Society.

[3]  H. Chui,et al.  Clinical subtypes of dementia of the Alzheimer type , 1985, Neurology.

[4]  R. Mayeux,et al.  Heterogeneity in dementia of the Alzheimer type , 1985, Neurology.

[5]  J. Morris,et al.  Aphasia, family history, and the longitudinal course of senile dementia of the alzheimer type , 1985, Psychiatry Research.

[6]  L. Iversen,et al.  Neurochemical characteristics of early and late onset types of Alzheimer's disease. , 1984, British medical journal.

[7]  Michael Swift,et al.  Alzheimer's disease: Genetic aspects and associated clinical disorders , 1983, Annals of neurology.

[8]  C. P. Hughes,et al.  A New Clinical Scale for the Staging of Dementia , 1982, British Journal of Psychiatry.

[9]  R. Lévy,et al.  Prediction of Outcome in Senile Dementia—A Computed Tomography Study , 1982, British Journal of Psychiatry.

[10]  R. Elston,et al.  The malignancy of dementias , 1978, Annals of neurology.

[11]  A. Kaszniak,et al.  Predictors of mortality in presenile and senile dementia , 1978, Annals of neurology.

[12]  M. Pike,et al.  Design and analysis of randomized clinical trials requiring prolonged observation of each patient. II. analysis and examples. , 1977, British Journal of Cancer.

[13]  J. Oxbury.  Assessment of brain damage. A neuropsychological key approach , 1972 .

[14]  J. Wepman.  Assessment of Brain Damage--A Neuropsychological Key Approach. , 1971 .

[15]  Á. Esteban,et al.  Myoclonus and photic-induced seizures in Alzheimer's disease. , 1971, European neurology.