Fluoro Substitution of Carcinogenic Aromatic Hydrocarbons: Models for Understanding Mechanisms of Metabolic Activation and of Oxygen Transfer Catalyzed by Cytochrome P450
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[1] E. Cavalieri,et al. Tumor-initiating activity in mouse skin and carcinogenicity in rat mammary gland of fluorinated derivatives of benzo[a]pyrene and 3-methylcholanthrene , 1988, Journal of Cancer Research and Clinical Oncology.
[2] E. Cavalieri,et al. Evidence that error-prone DNA repair converts dibenzo[a,l]pyrene-induced depurinating lesions into mutations: formation, clonal proliferation and regression of initiated cells carrying H-ras oncogene mutations in early preneoplasia. , 2000, Mutation research.
[3] J. M. Pratt,et al. The P450 catalytic cycle and oxygenation mechanism. , 1998, Drug metabolism reviews.
[4] S. Amin,et al. Comparative mouse skin tumorigenicity and induction of Ha-ras mutations by bay region diol epoxides of 5-methylchrysene and 5,6-dimethylchrysene. , 1998, Carcinogenesis.
[5] M. Gross,et al. Synthesis and structure determination of the adducts formed by electrochemical oxidation of 1,2,3,4-Tetrahydro-7,12-dimethylbenz[a]anthracene in the presence of deoxyribonucleosides or adenine. , 1996, Chemical research in toxicology.
[6] E. Cavalieri,et al. Expanded analysis of benzo[a]pyrene-DNA adducts formed in vitro and in mouse skin: their significance in tumor initiation. , 1996, Chemical research in toxicology.
[7] E. Cavalieri,et al. Radical cations of benzo[a]pyrene and 6-substituted derivatives: reaction with nucleophiles and DNA. , 1995, Xenobiotica; the fate of foreign compounds in biological systems.
[8] L. Marnett,et al. Comparison of the Peroxidase Activity of Hemoproteins and Cytochrome P450 , 1995 .
[9] D. Putt,et al. Cytochrome P450-catalyzed hydroxylation of hydrocarbons: kinetic deuterium isotope effects for the hydroxylation of an ultrafast radical clock. , 1994, Biochemistry.
[10] N. V. Ramakrishna,et al. Identification and quantitation of 7,12-dimethylbenz[a]anthracene-DNA adducts formed in mouse skin. , 1993, Chemical research in toxicology.
[11] N. V. Ramakrishna,et al. Mechanism of metabolic activation of the potent carcinogen 7,12-dimethylbenz[a]anthracene. , 1992, Chemical research in toxicology.
[12] N. V. Ramakrishna,et al. Synthesis and structure determination of the adducts of the potent carcinogen 7,12-dimethylbenz[a]anthracene and deoxyribonucleosides formed by electrochemical oxidation: models for metabolic activation by one-electron oxidation , 1992 .
[13] E. Cavalieri,et al. The approach to understanding aromatic hydrocarbon carcinogenesis. The central role of radical cations in metabolic activation. , 1992, Pharmacology & therapeutics.
[14] E. Cavalieri,et al. Tumorigenicity of 7,12-dimethylbenz[a]anthracene, some of its fluorinated derivatives, and l,2,3,4-tetrahydro-7,12-dimethylbenz[a]anthracene in mouse skin and rat mammary gland , 1990 .
[15] C. Ioannides,et al. Molecular orbital studies of oxygen activation and mechanisms of cytochromes P-450-mediated oxidative metabolism of xenobiotics. , 1989, Chemico-biological interactions.
[16] E. Cavalieri,et al. Radical cations in the horseradish peroxidase and prostaglandin H synthase mediated metabolism and binding of benzo[a]pyrene to deoxyribonucleic acid. , 1988, Biochemical pharmacology.
[17] E. Cavalieri,et al. Radical cations as precursors in the metabolic formation of quinones from benzo[a]pyrene and 6-fluorobenzo[a]pyrene. Fluoro substitution as a probe for one-electron oxidation in aromatic substrates. , 1988, Biochemical pharmacology.
[18] J. Dawson,et al. Probing structure-function relations in heme-containing oxygenases and peroxidases. , 1988, Science.
[19] J. M. Roman,et al. Characterization of 5-methylchrysene-1,2-dihydrodiol-3,4-epoxide-DNA adducts. , 1987, Carcinogenesis.
[20] P. D. Sullivan,et al. Carbon-13 and proton EPR analysis of the benzo[a]pyrene cation , 1985 .
[21] P. Fu,et al. Stereoselective metabolism of 8- and 9-fluorobenzo[a]pyrene by rat liver microsomes: absolute configurations of trans-dihydrodiol metabolites. , 1984, Journal of toxicology and environmental health.
[22] J. DiGiovanni,et al. Tumor initiating activity of 9- and 10-fluoro-7,12-dimethylbenz[a]-anthracene (DMBA) and the effect of 2,3,7,8-tetrachlorodibenzo-p-dioxin on tumor initiation by monofluoro derivatives of DMBA in SENCAR mice. , 1983, Carcinogenesis.
[23] T. Slaga,et al. Effect of a 6-fluoro substituent on the metabolism and biological activity of benzo(a)pyrene. , 1983, Cancer research.
[24] T. Slaga,et al. Tumor-initiating activity of 4-fluoro-7,12-dimethylbenz[a]anthracene and 1,2,3,4-tetrahydro-7,12-dimethylbenz[a]anthracene in female SENCAR mice. , 1982, Carcinogenesis.
[25] R. Haushalter,et al. High-valent iron-porphyrin complexes related to peroxidase and cytochrome P-450 , 1981 .
[26] C. S. Yang,et al. Metabolism of 7,12-dimethylbenz(a)anthracene and 7-hydroxymethyl-12-methylbenz(a)anthracene by rat liver and microsomes. , 1981, Cancer research.
[27] E. Cavalieri,et al. Metabolism of 6-substituted benzo[a]pyrene derivatives: O-dealkylation and regiospecificity in aromatic hydroxylation. , 1980, Journal of medicinal chemistry.
[28] S. Hecht,et al. Comparative mutagenicity, tumor-initiating activity, carcinogenicity, and in vitro metabolism of fluorinated 5-methylchrysenes. , 1979, Journal of the National Cancer Institute.
[29] T. Slaga,et al. Potent tumor-initiating activity of the 3,4-dihydrodiol of 7,12-dimethylbenz(a)anthracene in mouse skin. , 1979, Cancer research.
[30] T. Slaga,et al. Mutagenicity and tumor-initiating activity of fluorinated derivatives of 7,12-dimethylbenz(a)anthracene. , 1979, Cancer research.
[31] R. Harvey,et al. Multiple regions of metabolic activation of carcinogenic hydrocarbons , 1978, Nature.
[32] S. Hecht,et al. Tumor-initiating activity of fluorinated 5-methylchrysenes. , 1978, Cancer research.
[33] M. J. Coon,et al. Aliphatic hydroxylation by highly purified liver microsomal cytochrome P-450. Evidence for a carbon radical intermediate. , 1978, Biochemical and biophysical research communications.
[34] E. LaVoie,et al. On the metabolic activation of 5-methylchrysene , 1978 .
[35] P. Roller,et al. Enzymatic mechanism of benzo[a]pyrene conversion to phenols and diols and an improved high-pressure liquid chromatographic separation of benzo[a]pyrene derivatives. , 1977, Biochemistry.
[36] E. Cavalieri,et al. Reaction of methylbenzanthracenes and pyridine by one-electron oxidation. A model for metabolic activation and binding of carcinogenic aromatic hydrocarbons. , 1976, The Journal of organic chemistry.
[37] P. D. Sullivan,et al. Free radicals derived from benzo[a]pyrene. , 1976, Biochemical and biophysical research communications.
[38] J. Selkirk,et al. Separation of ten benzo(a)pyrene phenols by recycle high pressure liquid chromatography and identification of four phenols as metabolites. , 1976, Biochemical pharmacology.
[39] W. Caspary,et al. Autoxidation of 6-hydroxybenzo(a)pyrene and 6-oxobenzo(a)pyrene radical, reactive metabolites of benzo(a)pyrene , 1975 .
[40] A. Y. Lu,et al. Effects of inducers and epoxide hydrase on the metabolism of benzo(a)pyrene by liver microsomes and a reconstituted system: analysis by high pressure liquid chromatography. , 1974, Proceedings of the National Academy of Sciences of the United States of America.
[41] S. Hecht,et al. Chrysene and methylchrysenes: presence in tobacco smoke and carcinogenicity. , 1974, Journal of the National Cancer Institute.
[42] E. Cavalieri,et al. Reactions between activated benzo(a)pyrene and nucleophilic compounds, with possible implications on the mechanism of tumor initiation. , 1974, Journal of the National Cancer Institute.
[43] G. Blackburn,et al. Binding of benzo[α]pyrene to DNA investigated by tritium displacement , 1974 .
[44] W. Caspary,et al. Electron paramagnetic resonance study of iodine-induced radicals of benzo( ) pyrene and other polycyclic hydrocarbons. , 1973, Biochemistry.
[45] M. Calvin,et al. Induced Nucleophilic Substitution in Benzo[a]pyrene , 1973, Nature.
[46] M. Wilk,et al. Reactions between benzo(a)pyrene and nucleobases by one-electron oxidation. , 1972, Journal of the National Cancer Institute.
[47] J. Pataki,et al. Relative carcinogenicity of some diethylbenz(a)anthracenes. , 1972, Journal of medicinal chemistry.
[48] M. Calvin,et al. Molecular characteristics of some carcinogenic hydrocarbons. , 1971, Proceedings of the National Academy of Sciences of the United States of America.
[49] R. Adams,et al. Electrochemical oxidation pathways of benzo [a] pyrene. , 1970, Journal of the American Chemical Society.
[50] J. Rochlitz. Neue reaktionen der carcinogenen kohlenwasserstoffe—II , 1967 .
[51] M. Wilk,et al. Neue reaktionen der carcinogenen kohlenwasserstoffe 3,4-benzypyren, 9,10-dimethyl-1,2-benzanthracen und 20-methylcholanthren , 1966 .