Inhibition of BMP2‐induced, TAK1 kinase‐mediated neurite outgrowth by Smad6 and Smad7

Background BMP2 is known to play a wide variety of roles, including some in the development of the nervous system. This cytokine has been reported to induce neurite outgrowth in rat pheochromocytoma PC12 cells via the activation of a p38 MAP kinase, although its regulatory mechanism remains largely to be elucidated.

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