The GORKY glycoalkaloid transporter is indispensable for preventing tomato bitterness

[1]  A. Aharoni,et al.  Analysis of wild tomato introgression lines elucidates the genetic basis of transcriptome and metabolome variation underlying fruit traits and pathogen response , 2020, Nature Genetics.

[2]  A. Aharoni,et al.  Plant terpenoid metabolism co-opts a component of the cell wall biosynthesis machinery , 2020, Nature Chemical Biology.

[3]  S. Marillonnet,et al.  The Tapetal Major Facilitator NPF2.8 Is Required for Accumulation of Flavonol Glycosides on the Pollen Surface in Arabidopsis thaliana[OPEN] , 2020, Plant Cell.

[4]  K. Yazaki,et al.  Dynamism of vacuoles toward survival strategy in plants. , 2019, Biochimica et biophysica acta. Biomembranes.

[5]  A. Aharoni,et al.  Pathways to defense metabolites and evading fruit bitterness in genus Solanum evolved through 2-oxoglutarate-dependent dioxygenases , 2019, Nature Communications.

[6]  Yasset Perez-Riverol,et al.  The ProteomeXchange consortium in 2020: enabling ‘big data’ approaches in proteomics , 2019, Nucleic Acids Res..

[7]  B. Halkier,et al.  GTR-mediated radial import directs accumulation of defensive glucosinolates to sulfur-rich cells (S-cells) in phloem cap of inflorescence stem of Arabidopsis thaliana. , 2019, Molecular plant.

[8]  R. Aiese Cigliano,et al.  Mutation of a bHLH transcription factor allowed almond domestication , 2019, Science.

[9]  J. Dean,et al.  Transport of Anthocyanins and other Flavonoids by the Arabidopsis ATP-Binding Cassette Transporter AtABCC2 , 2019, Scientific Reports.

[10]  S. Luan,et al.  Identification of vacuolar phosphate efflux transporters in land plants , 2019, Nature Plants.

[11]  Martin Eisenacher,et al.  The PRIDE database and related tools and resources in 2019: improving support for quantification data , 2018, Nucleic Acids Res..

[12]  A. Aharoni,et al.  DLEMMA-MS-Imaging for Identification of Spatially Localized Metabolites and Metabolic Network Map Reconstruction. , 2018, Analytical chemistry.

[13]  E. Martinoia,et al.  The Vacuolar Transportome of Plant Specialized Metabolites , 2018, Plant & cell physiology.

[14]  Sudhir Kumar,et al.  MEGA X: Molecular Evolutionary Genetics Analysis across Computing Platforms. , 2018, Molecular biology and evolution.

[15]  A. Aharoni,et al.  Short-chain dehydrogenase/reductase governs steroidal specialized metabolites structural diversity and toxicity in the genus Solanum , 2018, Proceedings of the National Academy of Sciences.

[16]  Jie Luo,et al.  Rewiring of the Fruit Metabolome in Tomato Breeding , 2018, Cell.

[17]  E. M. Farré,et al.  Genome diversity of tuber-bearing Solanum uncovers complex evolutionary history and targets of domestication in the cultivated potato , 2017, Proceedings of the National Academy of Sciences.

[18]  Yasuyuki Yamada,et al.  A multidrug and toxic compound extrusion transporter mediates berberine accumulation into vacuoles in Coptis japonica. , 2017, Phytochemistry.

[19]  A. Aharoni,et al.  Label‐free deep shotgun proteomics reveals protein dynamics during tomato fruit tissues development , 2017, The Plant journal : for cell and molecular biology.

[20]  B. Halkier,et al.  Reduction of antinutritional glucosinolates in Brassica oilseeds by mutation of genes encoding transporters , 2017, Nature Biotechnology.

[21]  B. Halkier,et al.  Origin and evolution of transporter substrate specificity within the NPF family , 2017, eLife.

[22]  Sanwen Huang,et al.  A chemical genetic roadmap to improved tomato flavor , 2017, Science.

[23]  A. Pendle,et al.  An NPF Transporter Exports a Central Monoterpene Indole Alkaloid Intermediate from the Vacuole , 2016, Nature Plants.

[24]  B. Halkier,et al.  Rhizosecretion of stele-synthesized glucosinolates and their catabolites requires GTR-mediated import in Arabidopsis , 2016, Journal of experimental botany.

[25]  A. Aharoni,et al.  More than Pictures: When MS Imaging Meets Histology. , 2016, Trends in plant science.

[26]  N. Shitan,et al.  Secondary metabolites in plants: transport and self-tolerance mechanisms , 2016, Bioscience, biotechnology, and biochemistry.

[27]  A. Aharoni,et al.  GAME9 regulates the biosynthesis of steroidal alkaloids and upstream isoprenoids in the plant mevalonate pathway , 2016, Nature Communications.

[28]  A. Aharoni,et al.  Sample Preparation for Mass Spectrometry Imaging of Plant Tissues: A Review , 2016, Front. Plant Sci..

[29]  A. Granell,et al.  A modular toolbox for gRNA–Cas9 genome engineering in plants based on the GoldenBraid standard , 2016, Plant Methods.

[30]  J. A. Smith,et al.  Isolation of Tonoplast Vesicles from Tomato Fruit Pericarp. , 2015, Bio-protocol.

[31]  B. Halkier,et al.  Transport of defense compounds from source to sink: lessons learned from glucosinolates. , 2015, Trends in plant science.

[32]  J. A. Smith,et al.  A tonoplast Glu/Asp/GABA exchanger that affects tomato fruit amino acid composition , 2015, The Plant journal : for cell and molecular biology.

[33]  Xiaoquan Qi,et al.  Biosynthesis, regulation, and domestication of bitterness in cucumber , 2014, Science.

[34]  Kui Lin,et al.  Genomic analyses provide insights into the history of tomato breeding , 2014, Nature Genetics.

[35]  X. Draye,et al.  Measuring the osmotic water permeability coefficient (Pf) of spherical cells: isolated plant protoplasts as an example. , 2014, Journal of visualized experiments : JoVE.

[36]  Jun Wang,et al.  Exploring genetic variation in the tomato (Solanum section Lycopersicon) clade by whole-genome sequencing. , 2014, The Plant journal : for cell and molecular biology.

[37]  Hideyuki Suzuki,et al.  Steroidal glycoalkaloid profiling and structures of glycoalkaloids in wild tomato fruit. , 2013, Phytochemistry.

[38]  Qiang Chen,et al.  Efficient agroinfiltration of plants for high-level transient expression of recombinant proteins. , 2013, Journal of visualized experiments : JoVE.

[39]  A. Aharoni,et al.  Biosynthesis of Antinutritional Alkaloids in Solanaceous Crops Is Mediated by Clustered Genes , 2013, Science.

[40]  H. Noronha,et al.  Vacuolar Transport of the Medicinal Alkaloids from Catharanthus roseus Is Mediated by a Proton-Driven Antiport1[W] , 2013, Plant Physiology.

[41]  M. M. Chaves,et al.  ABCC1, an ATP Binding Cassette Protein from Grape Berry, Transports Anthocyanidin 3-O-Glucosides[W][OA] , 2013, Plant Cell.

[42]  R. Hedrich,et al.  NRT/PTR transporters are essential for translocation of glucosinolate defence compounds to seeds , 2012, Nature.

[43]  A. Cardona,et al.  Fiji: an open-source platform for biological-image analysis , 2012, Nature Methods.

[44]  S. Neumann,et al.  CAMERA: an integrated strategy for compound spectra extraction and annotation of liquid chromatography/mass spectrometry data sets. , 2012, Analytical chemistry.

[45]  A. Aharoni,et al.  GLYCOALKALOID METABOLISM1 Is Required for Steroidal Alkaloid Glycosylation and Prevention of Phytotoxicity in Tomato[W] , 2011, Plant Cell.

[46]  Peter W. Jones,et al.  Bioactivities of glycoalkaloids and their aglycones from Solanum species. , 2011, Journal of agricultural and food chemistry.

[47]  J. Vincken,et al.  C22 isomerization in alpha-tomatine-to-esculeoside A conversion during tomato ripening is driven by C27 hydroxylation of triterpenoidal skeleton. , 2009, Journal of agricultural and food chemistry.

[48]  Cathie Martin,et al.  A Visual Reporter System for Virus-Induced Gene Silencing in Tomato Fruit Based on Anthocyanin Accumulation1[C][W] , 2009, Plant Physiology.

[49]  M. Mann,et al.  Universal sample preparation method for proteome analysis , 2009, Nature Methods.

[50]  D. Shibata,et al.  Involvement of ethylene in the accumulation of esculeoside A during fruit ripening of tomato (Solanum lycopersicum). , 2009, Journal of agricultural and food chemistry.

[51]  D. Inzé,et al.  Vacuolar transport of nicotine is mediated by a multidrug and toxic compound extrusion (MATE) transporter in Nicotiana tabacum , 2009, Proceedings of the National Academy of Sciences.

[52]  K. Matsuoka,et al.  Multidrug and Toxic Compound Extrusion-Type Transporters Implicated in Vacuolar Sequestration of Nicotine in Tobacco Roots1[C][W] , 2008, Plant Physiology.

[53]  Thomas D. Schmittgen,et al.  Analyzing real-time PCR data by the comparative CT method , 2008, Nature Protocols.

[54]  S. Kanaya,et al.  Metabolite annotations based on the integration of mass spectral information , 2008, The Plant journal : for cell and molecular biology.

[55]  E. Çapanoğlu,et al.  Tissue specialization at the metabolite level is perceived during the development of tomato fruit. , 2007, Journal of experimental botany.

[56]  Andreas Nebenführ,et al.  A multicolored set of in vivo organelle markers for co-localization studies in Arabidopsis and other plants. , 2007, The Plant journal : for cell and molecular biology.

[57]  R. Verpoorte,et al.  Role of vacuolar transporter proteins in plant secondary metabolism: Catharanthus roseus cell culture , 2007, Phytochemistry Reviews.

[58]  M. Friedman.  Potato glycoalkaloids and metabolites: roles in the plant and in the diet. , 2006, Journal of agricultural and food chemistry.

[59]  Morten H. H. Nørholm,et al.  Advancing uracil-excision based cloning towards an ideal technique for cloning PCR fragments , 2006, Nucleic acids research.

[60]  R. Abagyan,et al.  XCMS: processing mass spectrometry data for metabolite profiling using nonlinear peak alignment, matching, and identification. , 2006, Analytical chemistry.

[61]  V. Walbot,et al.  A Multidrug Resistance–Associated Protein Involved in Anthocyanin Transport in Zea mays , 2004, The Plant Cell Online.

[62]  M. Friedman.  Tomato glycoalkaloids: role in the plant and in the diet. , 2002, Journal of agricultural and food chemistry.

[63]  S. Dinesh-Kumar,et al.  Virus-induced gene silencing in tomato. , 2002, The Plant journal : for cell and molecular biology.

[64]  T. Kuroiwa,et al.  A complex and mobile structure forms a distinct subregion within the continuous vacuolar membrane in young cotyledons of Arabidopsis. , 2002, The Plant journal : for cell and molecular biology.

[65]  H. Vanetten,et al.  Fungal Sensitivity to and Enzymatic Degradation of the Phytoanticipin alpha-Tomatine. , 1998, Phytopathology.

[66]  M. Friedman,et al.  Effect of alpha-tomatine and tomatidine on membrane potential of frog embryos and active transport of ions in frog skin. , 1997, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

[67]  M. Friedman.  Potato Polyphenols: Role in the Plant and in the Diet , 1997 .

[68]  W. Jongen,et al.  Glycoalkaloids selectively permeabilize cholesterol containing biomembranes. , 1996, Biochimica et biophysica acta.

[69]  A. D. Jones,et al.  High alpha-tomatine content in ripe fruit of Andean Lycopersicon esculentum var. cerasiforme: developmental and genetic aspects. , 1994, Proceedings of the National Academy of Sciences of the United States of America.

[70]  T. Johns,et al.  Glycoalkaloid change during the domestication of the potato, Solanum Section Petota , 1990, Euphytica.

[71]  David Brink,et al.  : A Review of the , 2018 .

[72]  Yuan Tang,et al.  ggfortify: Unified Interface to Visualize Statistical Results of Popular R Packages , 2016, R J..

[73]  Diego Orzaez,et al.  Design and construction of multigenic constructs for plant biotechnology using the GoldenBraid cloning strategy. , 2014, Methods in molecular biology.

[74]  G. Coruzzi,et al.  A unified nomenclature of NITRATE TRANSPORTER 1/PEPTIDE TRANSPORTER family members in plants. , 2014, Trends in plant science.

[75]  R. Hoagland.  Toxicity of tomatine and tomatidine on weeds, crops and phytopathogenetic fungi , 2009 .

[76]  C. Eyers.  Universal sample preparation method for proteome analysis , 2009 .

[77]  BMC Plant Biology BioMed Central , 2008 .

[78]  G. Gao,et al.  Preliminary study of action mechanism of tomatine toxicity to {\sl Helicoverpa armigera} , 2006 .

[79]  James G. Roddick,et al.  Destabilization of liposome membranes by the steroidal glycoalkaloid α-tomatine , 1984 .

[80]  J. G. Surak,et al.  The toxicity of α-Tomatine to Tetrahymena pyriformis☆ , 1979 .

[81]  J. G. Roddick.  Intracellular distribution of the steroidal glycoalkaloid α-tomatine in Lycopersicon esculentum fruit , 1976 .