Abstract In accordance with Article 6 of Regulation (EC) No 396/2005, the applicant Dow AgroSciences Ltd submitted a request to the competent national authority in France and the Netherlands to modify the existing maximum residue levels (MRL) for the active substance spinetoram in several crops. The data submitted in support of the requests were found to be sufficient for making several MRL proposals for the crops under consideration. Adequate analytical methods for enforcement are available to control the residues of spinetoram on the commodities under consideration. Based on the risk assessment results, EFSA concluded that a risk from short‐term intake cannot be excluded for escaroles. Therefore, no MRL has been proposed for this use. Furthermore, in a screening step, risk to consumers has been identified for the current use of spinetoram in lettuce. EFSA therefore proposes to lower the current MRL for lettuce to a safe limit. For the remaining crops, the expected short‐term exposure is unlikely to present a risk to consumer health. The long‐term intake of residues resulting from the uses of spinetoram according to the reported agricultural practices is unlikely to present a risk to public health.