The Merlin/NF2 tumor suppressor functions through the YAP oncoprotein to regulate tissue homeostasis in mammals.
暂无分享,去创建一个
M. Giovannini | P. Liu | R. Anders | Yonggang Zheng | D. Pan | Jixin Dong | Nailing Zhang | K. David | Haibo Bai | Jing Cai | Pentao Liu
[1] J. Wrana,et al. Phosphorylation of the Tumor Suppressor Fat Is Regulated by Its Ligand Dachsous and the Kinase Discs Overgrown , 2009, Current Biology.
[2] P J Bryant,et al. The Drosophila tumor suppressor gene warts encodes a homolog of human myotonic dystrophy kinase and is required for the control of cell shape and proliferation. , 1995, Genes & development.
[3] N. Tapon,et al. The Salvador partner Hippo promotes apoptosis and cell-cycle exit in Drosophila , 2003, Nature Cell Biology.
[4] S. Goff,et al. Deletion of DDB1 in Mouse Brain and Lens Leads to p53-Dependent Elimination of Proliferating Cells , 2006, Cell.
[5] F. Giancotti,et al. Shedding light on Merlin's wizardry. , 2007, Trends in cell biology.
[6] K. Irvine,et al. In vivo regulation of Yorkie phosphorylation and localization , 2008, Development.
[7] J. Golfinos,et al. Consensus Recommendations to Accelerate Clinical Trials for Neurofibromatosis Type 2 , 2009, Clinical Cancer Research.
[8] Jonathan A. Cooper,et al. Merlin/NF2 Suppresses Tumorigenesis by Inhibiting the E3 Ubiquitin Ligase CRL4DCAF1 in the Nucleus , 2010, Cell.
[9] I. Hariharan,et al. The Drosophila tumor suppressors Expanded and Merlin differentially regulate cell cycle exit, apoptosis, and Wingless signaling. , 2007, Developmental biology.
[10] J. Avruch,et al. MOBKL1A/MOBKL1B Phosphorylation by MST1 and MST2 Inhibits Cell Proliferation , 2008, Current Biology.
[11] Ryan S. Udan,et al. Hippo promotes proliferation arrest and apoptosis in the Salvador/Warts pathway , 2003, Nature Cell Biology.
[12] K. Harvey,et al. Fat Cadherin Modulates Organ Size in Drosophila via the Salvador/Warts/Hippo Signaling Pathway , 2006, Current Biology.
[13] G. Thomas,et al. Conditional biallelic Nf 2 mutation in the mouse promotes manifestations of human neurofibromatosis type 2 , 2000 .
[14] R. DePinho,et al. Endogenous oncogenic K-ras(G12D) stimulates proliferation and widespread neoplastic and developmental defects. , 2004, Cancer cell.
[15] M. Giovannini,et al. Membrane organization and tumorigenesis--the NF2 tumor suppressor, Merlin. , 2005, Genes & development.
[16] K. Harvey,et al. Lgl, aPKC, and Crumbs Regulate the Salvador/Warts/Hippo Pathway through Two Distinct Mechanisms , 2010, Current Biology.
[17] Ryan S. Udan,et al. The Fat Cadherin Acts through the Hippo Tumor-Suppressor Pathway to Regulate Tissue Size , 2006, Current Biology.
[18] R. Jaenisch,et al. YAP1 Increases Organ Size and Expands Undifferentiated Progenitor Cells , 2007, Current Biology.
[19] G. Halder,et al. The tumour-suppressor genes NF2/Merlin and Expanded act through Hippo signalling to regulate cell proliferation and apoptosis , 2006, Nature Cell Biology.
[20] R. Fehon,et al. Delineation of a Fat tumor suppressor pathway , 2006, Nature Genetics.
[21] Juan Huang,et al. Crumbs Regulates Salvador/Warts/Hippo Signaling in Drosophila via the FERM-Domain Protein Expanded , 2010, Current Biology.
[22] P. Mazur,et al. Liver‐specific inactivation of Notch2, but not Notch1, compromises intrahepatic bile duct development in mice , 2008, Hepatology.
[23] B. Wang,et al. The TEAD/TEF family of transcription factor Scalloped mediates Hippo signaling in organ size control. , 2008, Developmental cell.
[24] Y. Nakanuma,et al. Immunohistochemical study on bile ductular proliferation in various hepatobiliary diseases. , 2008, Liver.
[25] Shian Wu,et al. The TEAD/TEF family protein Scalloped mediates transcriptional output of the Hippo growth-regulatory pathway. , 2008, Developmental cell.
[26] K. Irvine,et al. Processing and phosphorylation of the Fat receptor , 2009, Proceedings of the National Academy of Sciences.
[27] Juan Huang,et al. The apical transmembrane protein Crumbs functions as a tumor suppressor that regulates Hippo signaling by binding to Expanded , 2010, Proceedings of the National Academy of Sciences.
[28] N. Tapon,et al. The Tumor-Suppressor Gene fat Controls Tissue Growth Upstream of Expanded in the Hippo Signaling Pathway , 2006, Current Biology.
[29] Ju-Seog Lee,et al. Hippo signaling is a potent in vivo growth and tumor suppressor pathway in the mammalian liver , 2010, Proceedings of the National Academy of Sciences.
[30] D. Haber,et al. salvador Promotes Both Cell Cycle Exit and Apoptosis in Drosophila and Is Mutated in Human Cancer Cell Lines , 2002, Cell.
[31] F. Lemaigre. Development of the biliary tract , 2003, Mechanisms of Development.
[32] R. Fehon,et al. Structural Analysis of Drosophila Merlin Reveals Functional Domains Important for Growth Control and Subcellular Localization , 1998, The Journal of cell biology.
[33] Shian Wu,et al. hippo Encodes a Ste-20 Family Protein Kinase that Restricts Cell Proliferation and Promotes Apoptosis in Conjunction with salvador and warts , 2003, Cell.
[34] B. Wang,et al. The Drosophila Ste20 family kinase dMST functions as a tumor suppressor by restricting cell proliferation and promoting apoptosis. , 2003, Genes & development.
[35] T. Magnuson,et al. Defects in Yolk Sac Vasculogenesis, Chorioallantoic Fusion, and Embryonic Axis Elongation in Mice with Targeted Disruption of Yap65 , 2006, Molecular and Cellular Biology.
[36] B. Stanger,et al. Notch signaling controls liver development by regulating biliary differentiation , 2009, Development.
[37] Li Li,et al. Inactivation of YAP oncoprotein by the Hippo pathway is involved in cell contact inhibition and tissue growth control. , 2007, Genes & development.
[38] Jeannie T. Lee,et al. Mst1 and Mst2 maintain hepatocyte quiescence and suppress hepatocellular carcinoma development through inactivation of the Yap1 oncogene. , 2009, Cancer cell.
[39] Xiaomu Wei,et al. Mob as tumor suppressor is activated by Hippo kinase for growth inhibition in Drosophila , 2007, The EMBO journal.
[40] B. Thompson,et al. Kibra Is a Regulator of the Salvador/Warts/Hippo Signaling Network , 2010, Developmental cell.
[41] Yaopan Mao,et al. Dachs: an unconventional myosin that functions downstream of Fat to regulate growth, affinity and gene expression in Drosophila , 2006, Development.
[42] R. Fehon,et al. The Tumor Suppressors Merlin and Expanded Function Cooperatively to Modulate Receptor Endocytosis and Signaling , 2006, Current Biology.
[43] G. Feldmann,et al. Elucidation of a Universal Size-Control Mechanism in Drosophila and Mammals , 2007, Cell.
[44] Ying Li,et al. Control of Cell Proliferation and Apoptosis by Mob as Tumor Suppressor, Mats , 2005, Cell.
[45] W. Deng,et al. Kibra functions as a tumor suppressor protein that regulates Hippo signaling in conjunction with Merlin and Expanded. , 2010, Developmental cell.
[46] G. Gores,et al. Induction of intrahepatic cholangiocellular carcinoma by liver-specific disruption of Smad4 and Pten in mice. , 2006, The Journal of clinical investigation.
[47] Henry C. Pitot,et al. Use of a low-speed, iso-density percoll centrifugation method to increase the viability of isolated rat hepatocyte preparations , 1986, In Vitro Cellular & Developmental Biology.
[48] P Robin Hiesinger,et al. Shar-pei mediates cell proliferation arrest during imaginal disc growth in Drosophila , 2002, Development.
[49] M. Wigler,et al. Identification and Validation of Oncogenes in Liver Cancer Using an Integrative Oncogenomic Approach , 2006, Cell.
[50] D. Paul,et al. Connexin43 is required for production of the aqueous humor in the murine eye , 2006, Journal of Cell Science.
[51] Jianbin Huang,et al. The Hippo Signaling Pathway Coordinately Regulates Cell Proliferation and Apoptosis by Inactivating Yorkie, the Drosophila Homolog of YAP , 2005, Cell.
[52] T. Jacks,et al. The Nf2 tumor suppressor gene product is essential for extraembryonic development immediately prior to gastrulation. , 1997, Genes & development.
[53] A. Berns,et al. Conditional biallelic Nf2 mutation in the mouse promotes manifestations of human neurofibromatosis type 2. , 2000, Genes & development.
[54] T. Xu,et al. Identifying tumor suppressors in genetic mosaics: the Drosophila lats gene encodes a putative protein kinase. , 1995, Development.
[55] R. M. Simpson,et al. Mammalian Mst1 and Mst2 kinases play essential roles in organ size control and tumor suppression , 2010, Proceedings of the National Academy of Sciences.
[56] M. Kaiser-Kupfer,et al. Lens opacities in neurofibromatosis 2: further significant correlations. , 1993, The British journal of ophthalmology.
[57] Jianmin Zhang,et al. Transforming properties of YAP, a candidate oncogene on the chromosome 11q22 amplicon , 2006, Proceedings of the National Academy of Sciences.
[58] D. Tyler,et al. Expanded and fat regulate growth and differentiation in the Drosophila eye through multiple signaling pathways. , 2007, Developmental biology.
[59] D. Flagiello,et al. SCALLOPED Interacts with YORKIE, the Nuclear Effector of the Hippo Tumor-Suppressor Pathway in Drosophila , 2008, Current Biology.
[60] N. Copeland,et al. A highly efficient recombineering-based method for generating conditional knockout mutations. , 2003, Genome research.
[61] I. Hariharan,et al. The Drosophila Mst Ortholog, hippo, Restricts Growth and Cell Proliferation and Promotes Apoptosis , 2003, Cell.
[62] Ingrid Poernbacher,et al. The WW domain protein Kibra acts upstream of Hippo in Drosophila. , 2010, Developmental cell.