Relative biological effectiveness for protons of energies up to 31 MeV.

The relative biological effectiveness (RBE) was determined for proton beams of 31, 12, and 8 MeV produced at the Milano University Cyclotron. Survival curves for human cells grown in monolayer at different proton energies and for γ rays from60 Co were determined. The minimum clone size to be chosen for definition of true survivors was examined. RBE values of 1.0 ± 0.1, 1.4 ± 0.2, and 1.5 ± 0.2, respectively, were found and compared with the results of other experiments in this energy range.

[1]  A. Westra,et al.  Proliferation characteristics of cultured mammalian cells after irradiation with sparsely and densely ionizing radiations. , 1966, International journal of radiation biology and related studies in physics, chemistry, and medicine.

[2]  S. Graffman,et al.  Clinical trials in radiotherapy and the merits of high energy protons. , 1970, Acta radiologica: therapy, physics, biology.

[3]  Albrecht M. Kellerer,et al.  THEORY OF DUAL RADIATION ACTION. , 1972 .

[4]  B. Larsson,et al.  Chromosome aberrations following irradiation with high-energy protons and their secondary radiation: a study of dose distribution and biological efficiency using root-tips of Vicia faba and Allium cepa. , 1960, International journal of radiation biology and related studies in physics, chemistry, and medicine.

[5]  E. Hall,et al.  RBE as a function of neutron energy. II. Statistical analysis. , 1976, Radiation Research.

[6]  J. Lyman,et al.  HEAVY-CHARGED-PARTICLE BEAMS. , 1968 .

[7]  E. Hall,et al.  RBE as a function of neutron energy , 1975 .

[8]  W Schimmerling,et al.  Apparatus and dosimetry for high-energy heavy-ion-beam irradiations. , 1976, Radiation research.

[9]  T. Puck,et al.  ACTION OF X-RAYS ON MAMMALIAN CELLS , 1956, The Journal of experimental medicine.

[10]  K H Chadwick,et al.  A molecular theory of cell survival. , 1973, Physics in medicine and biology.

[11]  J. Till,et al.  QUANTITATION OF CELLULAR RADIOBIOLOGICAL RESPONSES. , 1964, Annual review of nuclear science.

[12]  R. Madey,et al.  Range-energy tables , 1954 .

[13]  R. A. Armer,et al.  Dosimetry and apparatus for heavy ion irradiation of mammalian cells in vitro. , 1968, Radiation research.

[14]  M. Fox,et al.  Minimum clone size for estimating normal reproductive capacity of cultured cells. , 1968, The British journal of radiology.

[15]  G. Neary.  IRRADIATION OF SIMPLE BIOLOGICAL SPECIMENS BY CHARGED PARTICLES. , 1970 .

[16]  A. Koehler,et al.  Protons in radiation therapy. Comparative dose distributions for protons, photons, and electrons. , 1972, Radiology.

[17]  J. B. Cumming,et al.  Absolute cross section for the C12(p, pn)C11 reaction at 50 MeV , 1963 .

[18]  J. Sayeg,et al.  The effects of accelerated carbon nuclei and other radiations on the survival of haploid yeast. I. Dosimetry of the cyclotron beams. , 1959, Radiation research.

[19]  J. Archambeau,et al.  Proton radiation therapy. , 1974, Radiology.