CANCER-ASSOCIATED ADIPOCYTES AND PROGNOSTIC VALUE OF PREOPERATIVE NEUTROPHIL-LYMPHOCYTE RATIO IN GASTRIC CANCER.

BACKGROUND The neutrophil-to-lymphocyte ratio (NLR) turned out to be a routinely available marker capable to reflect the systemic inflammatory response created by a tumor. Gastric cancer (GC) grows in the anatomical vicinity of adipose tissue, which is also associated with low-grade inflammation. AIM To investigate the usefulness of the combined use of preoperative NLR and density of intratumoral cancer-associated adipocytes (CAAs) for predicting the disease outcome in GC patients. MATERIALS AND METHODS A total of 151 patients with GC were eligible for retrospective analysis between 2009 and 2015.NLR preoperative values were calculated. Perilipin expression in tumor tissue was examined immunohistochemically. RESULTS Low preoperative NLR is the most reliable prognostic factor for the favorable outcome for patients with low density of intratumoral CAAs. Patients with a high density of CCAs are at high risk of lethal outcomes independently of the value of preoperative NLR. CONCLUSION The results have clearly shown an association between preoperative NLR and the density of CAAs in the primary tumor of GC patients. The prognostic value of NLR is essentially modified by means of the individual density of intratumoral CAAs in GC patients.The elevated NLR could be of significant predictive potential for a negative prognosis for patients with tumors characterized by the high density of CAAs independently of BMI.

[1]  T. Luedde,et al.  Overweight and Obesity Determine the Risk for Gastrointestinal Cancer in a Sex-Dependent Manner: A Retrospective Cohort Study of 287,357 Outpatients in Germany , 2022, Cancers.

[2]  G. Dai,et al.  Neutrophil-to-Lymphocyte Ratio (NLR) Predicts PD-1 Inhibitor Survival in Patients with Metastatic Gastric Cancer , 2021, Journal of immunology research.

[3]  L. Lynch,et al.  Immune and non-immune functions of adipose tissue leukocytes , 2021, Nature Reviews Immunology.

[4]  Liaoliao Dong,et al.  Neutrophils in cancer carcinogenesis and metastasis , 2021, Journal of Hematology & Oncology.

[5]  Yangfan Zhang,et al.  Prognostic Value of Pretreatment Overweight/Obesity and Adipose Tissue Distribution in Resectable Gastric Cancer: A Retrospective Cohort Study , 2021, Frontiers in Oncology.

[6]  Z. Ye,et al.  Prognostic value of preoperative body mass index for diabetic patients with non-metastasis gastric cancer: a single center experience , 2021, BMC Surgery.

[7]  Xiaoyan Jin,et al.  Prognostic implications of the peripheral platelet-to-lymphocyte ratio and neutrophil-to-lymphocyte ratio in predicting pathologic complete response after neoadjuvant chemotherapy in breast cancer patients. , 2021, Gland surgery.

[8]  U. Topal,et al.  Clinical Value of Hemoglobin and Albumin Levels and Lymphocyte And Platelet Count (HALP) Combination in Predicting Postoperative Complications, Lymph Node Positivity and Prognosis in Gastric Cancer Patients Who Underwent Curative Surgical Resection , 2020 .

[9]  Saptarshi Biswas,et al.  Innovations in Medicine and Medical Research Vol. 3 , 2020 .

[10]  Wu-Hu Zhang,et al.  Haemoglobin, albumin, lymphocyte and platelet predicts postoperative survival in pancreatic cancer , 2020, World journal of gastroenterology.

[11]  Ya-Ni Wang,et al.  Advances in research on the interaction between inflammation and cancer , 2019, The Journal of international medical research.

[12]  L. Bubnovskaya,et al.  Tumor-Infiltrating Lymphocytes in Primary Tumor and Bone Marrow in Patients with Gastric Cancer and Overweight , 2019 .

[13]  L. Lynch,et al.  Innate Immune Control of Adipose Tissue Homeostasis. , 2019, Trends in immunology.

[14]  Mohammad Safiqul Islam,et al.  How the association between obesity and inflammation may lead to insulin resistance and cancer. , 2019, Diabetes & metabolic syndrome.

[15]  J. O’Sullivan,et al.  Obesity and gastrointestinal cancer: the interrelationship of adipose and tumour microenvironments , 2018, Nature Reviews Gastroenterology & Hepatology.

[16]  A. Xu,et al.  Can the neutrophil-lymphocyte ratio and platelet-lymphocyte ratio be beneficial in predicting lymph node metastasis and promising prognostic markers of gastric cancer patients? Tumor maker retrospective study. , 2018, International journal of surgery.

[17]  Chang-ming Huang,et al.  Prognostic importance of the preoperative modified systemic inflammation score for patients with gastric cancer , 2018, Gastric Cancer.

[18]  A. Dupré,et al.  Inflammation and cancer: What a surgical oncologist should know. , 2018, European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology.

[19]  Wei-min Li,et al.  The Neutrophil to Lymphocyte Ratio May Predict Benefit from Chemotherapy in Lung Cancer , 2018, Cellular Physiology and Biochemistry.

[20]  Xinrui Zhao,et al.  Prognostic roles of neutrophil to lymphocyte ratio and platelet to lymphocyte ratio in ovarian cancer: a meta-analysis of retrospective studies , 2018, Archives of Gynecology and Obstetrics.

[21]  Priya Bhardwaj,et al.  Obesity alters the lung myeloid cell landscape to enhance breast cancer metastasis through IL5 and GM-CSF , 2017, Nature Cell Biology.

[22]  N. Bhooshan,et al.  Neutrophil-Lymphocyte Ratio Is a Prognostic Marker in Patients with Locally Advanced (Stage IIIA and IIIB) Non-Small Cell Lung Cancer Treated with Combined Modality Therapy. , 2017, The oncologist.

[23]  Xuelei Ma,et al.  Are pretreatment neutrophil-lymphocyte ratio and platelet-lymphocyte ratio useful in predicting the outcomes of patients with small-cell lung cancer? , 2017, Oncotarget.

[24]  K. Tao,et al.  Omental adipocytes enhance the invasiveness of gastric cancer cells by oleic acid-induced activation of the PI3K-Akt signaling pathway. , 2017, The international journal of biochemistry & cell biology.

[25]  H. Gabra,et al.  Adiposity and cancer at major anatomical sites: umbrella review of the literature , 2017, British Medical Journal.

[26]  K. Yanaga,et al.  Preoperative Platelet-to-Albumin Ratio Predicts Prognosis of Patients with Pancreatic Ductal Adenocarcinoma After Pancreatic Resection. , 2017, Anticancer research.

[27]  Shenglin Ma,et al.  Prognostic value of preoperative NLR, dNLR, PLR and CRP in surgical renal cell carcinoma patients , 2017, World Journal of Urology.

[28]  Dazhi Xu,et al.  Preoperative neutrophil-to-lymphocyte ratio plus platelet-to-lymphocyte ratio in predicting survival for patients with stage I–II gastric cancer , 2016, Chinese journal of cancer.

[29]  Joonho Jung,et al.  Prognostic value of the neutrophil-to-lymphocyte ratio for overall and disease-free survival in patients with surgically treated esophageal squamous cell carcinoma , 2016, Tumor Biology.

[30]  M. Caligiuri,et al.  Obesity, Inflammation, and Cancer. , 2016, Annual review of pathology.

[31]  J. Bridgewater,et al.  Derived neutrophil lymphocyte ratio is predictive of survival from intermittent therapy in advanced colorectal cancer: a post hoc analysis of the MRC COIN study , 2016, British Journal of Cancer.

[32]  A. Matsuda,et al.  Prognostic Significance of Neutrophil-to-Lymphocyte Ratio and Platelet-to-Lymphocyte Ratio in Oncologic Outcomes of Esophageal Cancer: A Systematic Review and Meta-analysis , 2016, Annals of Surgical Oncology.

[33]  X. Qu,et al.  Prognostic significance of preoperative neutrophil/lymphocyte ratio and platelet/lymphocyte ratio in patients with gallbladder carcinoma , 2015, Clinical and Translational Oncology.

[34]  E. Blaak,et al.  Adipose Tissue Dysfunction and Impaired Metabolic Health in Human Obesity: A Matter of Oxygen? , 2015, Front. Endocrinol..

[35]  L. Alexandre,et al.  Pathophysiological mechanisms linking obesity and esophageal adenocarcinoma. , 2014, World journal of gastrointestinal pathophysiology.

[36]  C. Costagliola,et al.  New Insight into Adiponectin Role in Obesity and Obesity-Related Diseases , 2014, BioMed research international.

[37]  D. Jacobs,et al.  Commentary: Origins and evolution of body mass index (BMI): continuing saga. , 2014, International journal of epidemiology.

[38]  S. Clarke,et al.  The systemic inflammation-based neutrophil-lymphocyte ratio: experience in patients with cancer. , 2013, Critical reviews in oncology/hematology.

[39]  E. Lengyel,et al.  Adipose tissue and adipocytes support tumorigenesis and metastasis. , 2013, Biochimica et biophysica acta.

[40]  A. Neugut,et al.  Elevated Preoperative Neutrophil:Lymphocyte Ratio as a Predictor of Postoperative Disease Recurrence in Esophageal Cancer , 2011, Annals of Surgical Oncology.

[41]  M. Czech,et al.  Adipocyte dysfunctions linking obesity to insulin resistance and type 2 diabetes , 2008, Nature Reviews Molecular Cell Biology.

[42]  Hui Wang,et al.  Preoperative Neutrophil Lymphocyte Ratio and Platelet Lymphocyte Ratio Cannot Predict Lymph Node Metastasis and Prognosis in Patients with Early Gastric Cancer: a Single Institution Investigation in China , 2018, Current Medical Science.

[43]  G. Colditz,et al.  Obesity and Cancer: Evidence, Impact, and Future Directions. , 2018, Clinical chemistry.

[44]  X. Xie,et al.  Prognostic value of preoperative platelet-lymphocyte and neutrophil-lymphocyte ratio in patients undergoing surgery for esophageal squamous cell cancer. , 2016, Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus.