On bio-design of Argo-machine

We describe a non-deterministic abstract machine that searches according to oracle words in the design space to fit with its environment, cuts, transposes and pastes a set of tapes. On the basis of this construct a distributed concurrent computation with DNA by bio-molecules is proposed. For this purpose we are developing a site-guidable nuclease. Labeled oligonucleotides or PNA are used as an input. Two kinds of computation are discussed: 1) in vitro in a thermo-cycler or 2) in vivo after the transgene installation into living cells.

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