论文信息 - Towards sequence-based genomic selection of cattle

Towards sequence-based genomic selection of cattle

An international effort, the 1000 bull genomes project, aims to resequence the genomes of a large number of key ancestor bulls of the most important domestic cattle breeds. A new study reports on the first results of this important initiative based on the analysis of the first 234 bovine whole-genome sequences.

Michel Georges

[1] Judy H. Cho,et al. Finding the missing heritability of complex diseases , 2009, Nature.

[2] M. Goddard,et al. Prediction of total genetic value using genome-wide dense marker maps. , 2001, Genetics.

[3] P. VanRaden,et al. Harmful recessive effects on fertility detected by absence of homozygous haplotypes. , 2011, Journal of dairy science.

[4] P. Visscher,et al. Advantages and pitfalls in the application of mixed-model association methods , 2014, Nature Genetics.

[5] R. Veerkamp,et al. Whole-genome sequencing of 234 bulls facilitates mapping of monogenic and complex traits in cattle , 2014, Nature Genetics.

[6] Robert D Schnabel,et al. Genome-Wide Survey of SNP Variation Uncovers the Genetic Structure of Cattle Breeds , 2009, Science.

[7] Positional candidate cloning of a QTL in dairy cattle: identification of a missense mutation in the bovine DGAT1 gene with major effect on milk yield and composition. , 2002 .