Self-calibration for lensless color microscopy.

Lensless color microscopy (also called in-line digital color holography) is a recent quantitative 3D imaging method used in several areas including biomedical imaging and microfluidics. By targeting cost-effective and compact designs, the wavelength of the low-end sources used is known only imprecisely, in particular because of their dependence on temperature and power supply voltage. This imprecision is the source of biases during the reconstruction step. An additional source of error is the crosstalk phenomenon, i.e., the mixture in color sensors of signals originating from different color channels. We propose to use a parametric inverse problem approach to achieve self-calibration of a digital color holographic setup. This process provides an estimation of the central wavelengths and crosstalk. We show that taking the crosstalk phenomenon into account in the reconstruction step improves its accuracy.

[1]  Thierry Fournel,et al.  Inverse problem approaches for digital hologram reconstruction , 2011, Defense + Commercial Sensing.

[2]  Harry A Atwater,et al.  Plasmonic color filters for CMOS image sensor applications. , 2012, Nano letters.

[3]  G. Mie.  Beiträge zur Optik trüber Medien, speziell kolloidaler Metallösungen , 1908 .

[4]  C.S. Lin,et al.  Light guide for pixel crosstalk improvement in deep submicron CMOS image sensor , 2004, IEEE Electron Device Letters.

[5]  Yibo Zhang,et al.  Demosaiced pixel super-resolution for multiplexed holographic color imaging , 2016, Scientific Reports.

[6]  Klaus D. Hinsch.  REVIEW ARTICLE: Holographic particle image velocimetry , 2002 .

[7]  Seung-Man Yang,et al.  Characterizing and tracking single colloidal particles with video holographic microscopy. , 2007, Optics express.

[8]  László Orzó,et al.  In-line color digital holographic microscope for water quality measurements , 2010, Laser Applications in Life Sciences.

[9]  Ichirou Yamaguchi,et al.  Phase-shifting color digital holography. , 2002, Optics letters.

[10]  Dalibor Vukicevic,et al.  Dynamic digital holographic interferometry with three wavelengths. , 2003, Optics express.

[11]  T. Fournel,et al.  In-line particle holography with an astigmatic beam: setup self-calibration using an "inverse problems" approach. , 2014, Applied optics.

[12]  Christophe Ducottet,et al.  Numerical suppression of the twin image in in-line holography of a volume of micro-objects , 2008 .

[13]  Ferréol Soulez,et al.  Inverse-problem approach for particle digital holography: accurate location based on local optimization. , 2007, Journal of the Optical Society of America. A, Optics, image science, and vision.

[14]  Qin Chen,et al.  High transmission and low color cross-talk plasmonic color filters using triangular-lattice hole arrays in aluminum films. , 2010, Optics express.

[15]  J. Katz,et al.  Applications of Holography in Fluid Mechanics and Particle Dynamics , 2010 .

[16]  Peter Klages,et al.  Digital in-line holographic microscopy. , 2006, Applied optics.

[17]  J. Garcia-Sucerquia.  Color digital lensless holographic microscopy: laser versus LED illumination. , 2016, Applied optics.

[18]  Pierre Magnan,et al.  CMOS pixels crosstalk mapping and its influence on measurements accuracy for space applications , 2005, SPIE Remote Sensing.

[19]  Thierry Fournel,et al.  Digital Hologram Processing in On-Axis Holography , 2014 .

[20]  Aydogan Ozcan,et al.  Wide-field optical detection of nanoparticles using on-chip microscopy and self-assembled nanolenses , 2013, Nature Photonics.

[21]  Paul M. Hubel,et al.  Spatial frequency response of color image sensors: Bayer color filters and Foveon X3 , 2004, IS&T/SPIE Electronic Imaging.

[22]  R. Tsai,et al.  Crosstalk and microlens study in a color CMOS image sensor , 2003 .

[23]  Masao Hiramoto,et al.  Efficient colour splitters for high-pixel-density image sensors , 2013, Nature Photonics.

[24]  Suppression of the Moiré effect in sub-picosecond digital in-line holography. , 2007, Optics express.

[25]  Loïc Denis,et al.  Inline hologram reconstruction with sparsity constraints. , 2009, Optics letters.

[26]  Jean-Marc Dinten,et al.  Wide-field lensfree imaging of tissue slides , 2015, European Conference on Biomedical Optics.

[27]  Christophe Ducottet,et al.  Digital holography of particles: benefits of the ‘inverse problem’ approach , 2008 .

[28]  Nicolas Verrier,et al.  Improvement of the size estimation of 3D tracked droplets using digital in-line holography with joint estimation reconstruction , 2016 .

[29]  A. Stuart,et al.  Kendall's Advanced Theory of Statistics, Volume 1: Distribution Theory , 1988 .

[30]  Qin Chen,et al.  Spatial optical crosstalk in CMOS image sensors integrated with plasmonic color filters. , 2015, Optics express.

[31]  Thierry Fournel,et al.  Pixel super-resolution in digital holography by regularized reconstruction , 2017 .

[32]  Jianlin Zhao,et al.  Recording and reconstruction of a color holographic image by using digital lensless Fourier transform holography. , 2008, Optics express.

[33]  Brian J. Thompson,et al.  Fraunhofer Holography Applied to Particle Size Analysis a Reassessment , 1976 .

[34]  Patrick J. Wolfe,et al.  Spatio-Spectral Color Filter Array Design for Enhanced Image Fidelity , 2007, 2007 IEEE International Conference on Image Processing.

[35]  H Royer,et al.  An application of high-speed microholography: the mertology of fogs , 1974 .

[36]  Orly Yadid-Pecht,et al.  Crosstalk quantification, analysis, and trends in CMOS image sensors. , 2010, Applied optics.

[37]  Werner Jüptner,et al.  Digital recording and numerical reconstruction of holograms , 2002 .

[38]  Pascal Picart,et al.  Method of digital holographic recording and reconstruction using a stacked color image sensor. , 2010, Applied optics.

[39]  Wanqing Li,et al.  Modelling of color cross-talk in CMOS image sensors , 2002, 2002 IEEE International Conference on Acoustics, Speech, and Signal Processing.

[40]  F. Nicolas,et al.  Digital in-line holography with a sub-picosecond laser beam , 2006 .

[41]  D. Gabor.  A New Microscopic Principle , 1948, Nature.

[42]  Sung-Ho Hwang,et al.  Improvement of crosstalk on 5M CMOS image sensor with 1.7x1.7&mgr;m2 pixels , 2007, SPIE OPTO.

[43]  Hiroaki Ohkubo,et al.  High sensitivity and no-cross-talk pixel technology for embedded CMOS image sensor , 2000 .

[44]  J. Goodman.  Introduction to Fourier optics , 1969 .

[45]  Mozhdeh Seifi,et al.  Evaporating droplet hologram simulation for digital in-line holography setup with divergent beam. , 2013, Journal of the Optical Society of America. A, Optics, image science, and vision.

[46]  Thierry Fournel,et al.  On the single point resolution of on-axis digital holography. , 2010, Journal of the Optical Society of America. A, Optics, image science, and vision.

[47]  L. Repetto,et al.  Lensless digital holographic microscope with light-emitting diode illumination. , 2004, Optics letters.

[48]  Eric R Fossum,et al.  Color filter array patterns for small-pixel image sensors with substantial cross talk. , 2015, Journal of the Optical Society of America. A, Optics, image science, and vision.

[49]  C. P. Allier,et al.  Bacteria detection with thin wetting 
film lensless imaging , 2010, Biomedical optics express.

[50]  Mozhdeh Seifi,et al.  Accurate 3D tracking and size measurement of evaporating droplets using in-line digital holography and "inverse problems" reconstruction approach. , 2013, Optics express.