Alcohol and heart failure.

BACKGROUND Current heart failure (HF) guidelines note that alcohol use should be discouraged or restricted in patients with HF resulting from left ventricular systolic dysfunction. Existing knowledge is limited in the area of HF and alcohol. METHODS AND RESULTS The purpose of this article is to review the evidence regarding the acute and long-term use of alcohol in the setting of HF. In addition, general aspects about alcohol and alcoholic beverages that are important for understanding and interpreting alcohol-related literature are reviewed and that can be used when discussing alcoholic beverage use with patients with HF. CONCLUSIONS There is some emerging evidence that suggests light drinking (1 to 14 drinks per week) is safe and even beneficial in HF patients with ischemic left ventricular dysfunction (LVD). However, there are no effects of light drinking in HF patients with nonischemic LVD. Clinicians should reinforce the importance of evidence based pharmacologic and nonpharmacologic therapies in HF.

[1]  J. Muller,et al.  Prior alcohol consumption and mortality following acute myocardial infarction. , 2001, JAMA.

[2]  B. Howard,et al.  Congestive heart failure despite normal left ventricular systolic function in a population-based sample: the Strong Heart Study. , 2000, The American journal of cardiology.

[3]  G A Colditz,et al.  Moderate alcohol consumption and risk of coronary heart disease among women with type 2 diabetes mellitus. , 2000, Circulation.

[4]  J. Manson,et al.  Alcohol consumption and risk of coronary heart disease by diabetes status. , 2000, Circulation.

[5]  M. Domanski,et al.  Light-to-moderate alcohol consumption and prognosis in patients with left ventricular systolic dysfunction. , 2000, Journal of the American College of Cardiology.

[6]  E. Rimm Alcohol and cardiovascular disease , 2000, Current atherosclerosis reports.

[7]  A. Gavazzi,et al.  Alcohol abuse and dilated cardiomyopathy in men. , 2000, The American journal of cardiology.

[8]  J. Blood-Siegfried,et al.  A Historical Perspective on the Discovery of Adenyl Purines , 2000, Biological research for nursing.

[9]  S. Wannamethee,et al.  Alcohol intake and mortality in middle aged men with diagnosed coronary heart disease , 2000, Heart.

[10]  L. Fauchier,et al.  Comparison of long-term outcome of alcoholic and idiopathic dilated cardiomyopathy. , 2000, European heart journal.

[11]  G. Reaven,et al.  Moderate alcohol consumption, insulin resistance, and cardiovascular disease. , 2000 .

[12]  J. Manson,et al.  Moderate alcohol consumption and the risk of sudden cardiac death among US male physicians. , 1999, Circulation.

[13]  R. Solaro,et al.  Calcium sensitivity and the effect of the calcium sensitizing drug pimobendan in the alcoholic isolated rat atrium. , 1999, Journal of cardiovascular pharmacology.

[14]  Thomas D. Giles,et al.  Consensus recommendations for the management of chronic heart failure: Introduction , 1999 .

[15]  Jerome A. Yesavage,et al.  Gender Differences in Moderate Drinking Effects , 1999, Alcohol research & health : the journal of the National Institute on Alcohol Abuse and Alcoholism.

[16]  J. Buring,et al.  Mortality and light to moderate alcohol consumption after myocardial infarction , 1998, The Lancet.

[17]  D. Grobbee,et al.  Alcohol, blood pressure and hypertension. , 1998, Novartis Foundation symposium.

[18]  E. Diamandis,et al.  Wine as a biological fluid: History, production, and role in disease prevention , 1997, Journal of clinical laboratory analysis.

[19]  M. Nieminen,et al.  Acute heavy alcohol intake increases silent myocardial ischaemia in patients with stable angina pectoris. , 1996, Heart.

[20]  M A Konstam,et al.  Heart failure: evaluation and care of patients with left ventricular systolic dysfunction. , 1995, Journal of cardiac failure.

[21]  J. Moring,et al.  Alcohol-Induced Changes in Neuronal Membranes , 1995 .

[22]  D. Ciraulo,et al.  Interaction of Alcohol With Therapeutic Drugs and Drugs of Abuse , 1995 .

[23]  H. Kranzler,et al.  The Pharmacology of Alcohol Abuse , 1995, Handbook of Experimental Pharmacology.

[24]  D. Baker,et al.  Management of heart failure. II. Counseling, education, and lifestyle modifications. , 1994 .

[25]  M G Marmot,et al.  Alcohol and blood pressure: the INTERSALT study , 1994, BMJ.

[26]  A. G. Shaper,et al.  Alcohol and sudden cardiac death , 1992, British heart journal.

[27]  E. Lakatta,et al.  Ethanol acutely and reversibly suppresses excitation-contraction coupling in cardiac myocytes. , 1991, Circulation research.

[28]  E. Lakatta,et al.  Contractile, metabolic and electrophysiologic effects of ethanol in the isolated rat heart. , 1991, Journal of molecular and cellular cardiology.

[29]  E. Lakatta,et al.  Mechanism of myocardial contractile depression by clinical concentrations of ethanol. A study in ferret papillary muscles. , 1990, The Journal of clinical investigation.

[30]  L. Pohorecky,et al.  Pharmacology of ethanol. , 1988, Pharmacology & therapeutics.

[31]  W. Light,et al.  Alcoholism: Its Natural History, Chemistry and General Metabolism. , 1987 .

[32]  L. Gould,et al.  Effect of oral alcohol on left ventricular ejection fraction, volumes, and segmental wall motion in normals and in patients with recent myocardial infarction , 1985, Clinical cardiology.

[33]  T. Feldman,et al.  Adverse cardiac effects of acute alcohol ingestion in young adults. , 1985, Annals of internal medicine.

[34]  N. Christensen,et al.  Acute effects of alcohol on left ventricular function in healthy subjects at rest and during upright exercise. , 1985, The American journal of cardiology.

[35]  M. Nieminen,et al.  Acute effects of alcohol, beta blockade, and their combination on left ventricular function and hemodynamics in normal man. , 1983, European heart journal.

[36]  J. Heikkilä,et al.  Acute effects of alcohol on left ventricular dynamics during isometric exercise in normal subjects , 1983, Clinical cardiology.

[37]  B. Greenberg,et al.  Acute effects of alcohol in patients with congestive heart failure. , 1982, Annals of Internal Medicine.

[38]  J. Child,et al.  Cardiac Effects of Acute Ethanol Ingestion Unmasked by Autonomic Blockade , 1979, Circulation.

[39]  M. Schuckit,et al.  Drug and alcohol abuse : a clinical guide to diagnosis and treatment , 1979 .

[40]  G. Timmis,et al.  The basis for differences in ethanol-induced myocardial depression in normal subjects. , 1975, Circulation.

[41]  R. Ross,et al.  Acute effects of low doses of alcohol on left ventricular function by echocardiography. , 1975, Circulation.

[42]  L. Gould,et al.  Effects of whisky on heart conduction in cardiac patients. , 1974, Quarterly journal of studies on alcohol.

[43]  S. Ahmed,et al.  Depression of Myocardial Contractility with Low Doses of Ethanol in Normal Man , 1973, Circulation.

[44]  B. Saltin,et al.  Acute Effects of Ethanol Ingestion on the Response to Submaximal and Maximal Exercise in Man , 1970, Circulation.

[45]  N. Conway Haemodynamic effects of ethyl alcohol in patients with coronary heart disease. , 1968, British heart journal.