Harnessing nanotopography to enhance osseointegration of clinical orthopredic titanium implants- an in Vitro and in Vivo analysis. Frontiers Bioengineering and

We herein detail the osteoinductive potential of discrete nanodot and nanowire nanotopographies. We have examined the ability of modified titanium and titanium alloy (Ti64) surfaces to induce bone-specific gene activation and extracellular matrix protein expression in human skeletal stem cells (SSCs) in vitro , and de novo osteogenic response within a murine calvarial model in vivo . This study provides evidence of enhanced osteogenic response to nanowires 300 surface modifications, with important implications for clinical orthopedic application. de novo osteogenic response in a calvarial rat model.

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