Multivariate classification of cardiac autonomic function and echocardiographic abnormalities

Abnormalities in the function, physiology and the regulation of the heart can be diagnosed using echocardiography (ECHO) and analysis of heart rate variability (HRV). Patients with transthyretin amyloidosis often present increased wall thickness in the myocardium and/or autonomic dysfunction. We used a novel approach to analyse the relationship between these findings, using a combination of dimension reduction techniques and model based clustering.