Increase in Enterovirus D68 Infections in Young Children, United Kingdom, 2006–2016

We determined the change in seroprevalence of enterovirus D68 (EV-D68) in the United Kingdom in age-stratified cohorts from 2006 to 2016, the period during which EV-D68 emerged as a cause of severe respiratory disease occasionally leading to paralysis. Infections were acquired primarily in infants and young children, and incidence was markedly higher in 2016.

[1]  R. Scheuermann,et al.  Contemporary Circulating Enterovirus D68 Strains Have Acquired the Capacity for Viral Entry and Replication in Human Neuronal Cells , 2018, mBio.

[2]  Zhenglun Liang,et al.  Seroepidemiology of enterovirus D68 infection in infants and children in Jiangsu, China. , 2018, The Journal of infection.

[3]  S. Shrivastava,et al.  World Health Organization releases the list of blueprint priority diseases , 2018 .

[4]  S. Dominguez,et al.  Surveillance for enterovirus D68 in colorado children reveals continued circulation. , 2017, Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology.

[5]  S. de Lusignan,et al.  The emergence of enterovirus D68 in England in autumn 2014 and the necessity for reinforcing enterovirus respiratory screening , 2017, Epidemiology and Infection.

[6]  H. Niesters,et al.  Upsurge of Enterovirus D68, the Netherlands, 2016 , 2017, Emerging infectious diseases.

[7]  N. Zhang,et al.  ICAM-5/Telencephalin Is a Functional Entry Receptor for Enterovirus D68. , 2016, Cell host & microbe.

[8]  J. Sejvar,et al.  Acute Flaccid Myelitis in the United States, August-December 2014: Results of Nationwide Surveillance. , 2016, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

[9]  Paolo Piazza,et al.  Comparison of Next-Generation Sequencing Technologies for Comprehensive Assessment of Full-Length Hepatitis C Viral Genomes , 2016, Journal of Clinical Microbiology.

[10]  S. Midgley,et al.  Global emergence of enterovirus D68: a systematic review. , 2016, The Lancet. Infectious diseases.

[11]  M. Rossmann,et al.  Enterovirus D68 receptor requirements unveiled by haploid genetics , 2016, Proceedings of the National Academy of Sciences.

[12]  Koichiro Tamura,et al.  MEGA6: Molecular Evolutionary Genetics Analysis version 6.0. , 2013, Molecular biology and evolution.

[13]  S. Madhi,et al.  Worldwide emergence of multiple clades of enterovirus 68. , 2012, The Journal of general virology.

[14]  P. Simmonds.  SSE: a nucleotide and amino acid sequence analysis platform , 2012, BMC Research Notes.

[15]  S. Ostroff,et al.  Clusters of acute respiratory illness associated with human enterovirus 68--Asia, Europe, and United States, 2008-2010. , 2011, MMWR. Morbidity and mortality weekly report.

[16]  P. Klemola,et al.  Cellular tropism of human enterovirus D species serotypes EV‐94, EV‐70, and EV‐68 in vitro: Implications for pathogenesis , 2010, Journal of medical virology.

[17]  Mark A Pallansch,et al.  Morbidity and Mortality Weekly Report Editorial and Production Staff Vol. 55 / Ss-8 Surveillance Summaries 1 Enterovirus Surveillance — United States, 1970–2005 , 2022 .

[18]  N. Gay,et al.  Ten years of serological surveillance in England and Wales: methods, results, implications and action. , 2000, International journal of epidemiology.