Medication adherence in patients who have heart failure: a review of the literature.

Data indicate that nonadherence plays a major role in preventable rehospitalizations. The first step to improving adherence is determining the affecting factor. This article critically reviews the literature on factors affecting medication adherence in heart failure patients. Findings about effects of age, gender, race, and living status on adherence are quite inconsistent. Patients who believe taking medications is beneficial or who have no side effects are more adherent, as are those highly motivated to improve their well-being. Forgetfulness, social support, and patient-provider relationship are related to adherence. Providers seeking to increase adherence must consider patients' expectations for their health, their environment, their barriers to following prescribed regimen, and their understanding of their condition and how it relates to medication taking.

[1]  Theresa M. Marteau,et al.  Self-Reported Adherence to Cholesterol-Lowering Medication in Patients with Familial Hypercholesterolaemia: The Role of Illness Perceptions , 2004, Cardiovascular Drugs and Therapy.

[2]  M. Prasun,et al.  Heart failure in older adults: keys to successful management. , 2002, AACN clinical issues.

[3]  J. Avorn,et al.  Noncompliance with congestive heart failure therapy in the elderly. , 1994, Archives of internal medicine.

[4]  Paula Finn,et al.  American Heart Association--scientific sessions 2005. 13-16 November 2005, Dallas, TX, USA. , 2006, IDrugs : the investigational drugs journal.

[5]  R. Hershberger,et al.  Factors influencing knowledge of and adherence to self-care among patients with heart failure. , 1999, Archives of internal medicine.

[6]  M. Dimatteo Evidence-based strategies to foster adherence and improve patient outcomes. , 2004, JAAPA : official journal of the American Academy of Physician Assistants.

[7]  M. Rich,et al.  Angiotensin-converting enzyme inhibitor compliance and dosing among patients with heart failure. , 1999, American heart journal.

[8]  E. Proctor,et al.  Post-acute home care and hospital readmission of elderly patients with congestive heart failure. , 2004, Health & social work.

[9]  L. Burke,et al.  Adherence to angiotensin-converting enzyme inhibitor therapy for heart failure. , 2002, Progress in cardiovascular nursing.

[10]  L. Huang,et al.  Medication-taking behavior of the elderly. , 1996, The Kaohsiung journal of medical sciences.

[11]  P. Blenkiron The elderly and their medication: understanding and compliance in a family practice. , 1996, Postgraduate medical journal.

[12]  D. Bush,et al.  Patients with depression are less likely to follow recommendations to reduce cardiac risk during recovery from a myocardial infarction. , 2000, Archives of internal medicine.

[13]  K. Furie,et al.  Heart disease and stroke statistics--2008 update: a report from the American Heart Association Statistics Committee and Stroke Statistics Subcommittee. , 2007, Circulation.

[14]  B. Riegel,et al.  Facilitators and barriers to heart failure self-care. , 2002, Patient education and counseling.

[15]  P. Rodgers,et al.  Medication nonadherence: Part II--A pilot study in patients with congestive heart failure. , 1998, Managed care interface.

[16]  F. Hicks,et al.  Self-Management Decision Influences in Heart Failure , 2003, Clinical nursing research.

[17]  G. Fonarow,et al.  Compliance Behaviors of Elderly Patients With Advanced Heart Failure , 2003, The Journal of cardiovascular nursing.

[18]  I. Ford,et al.  Patients’ Perspectives on Statin Therapy for Treatment of Hypercholesterolaemia: A Qualitative Study , 2003, European journal of cardiovascular nursing : journal of the Working Group on Cardiovascular Nursing of the European Society of Cardiology.

[19]  M. Dimatteo,et al.  Social support and patient adherence to medical treatment: a meta-analysis. , 2004, Health psychology : official journal of the Division of Health Psychology, American Psychological Association.

[20]  M. Naylor,et al.  Factors Contributing to Rehospitalization of Elderly Patients with Heart Failure , 1997, The Journal of cardiovascular nursing.

[21]  Jeffrey A. Johnson,et al.  Development and Validation of a Survey to Assess Barriers to Drug Use in Patients with Chronic Heart Failure , 2002, Pharmacotherapy.

[22]  N. Col,et al.  The role of medication noncompliance and adverse drug reactions in hospitalizations of the elderly. , 1990, Archives of internal medicine.

[23]  V. Conn,et al.  Cognitive impairment and medication adherence. , 1994, Journal of gerontological nursing.

[24]  F. Dobbels,et al.  Effect of late medication non-compliance on outcome after heart transplantation: a 5-year follow-up. , 2004, The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation.

[25]  R. Carney,et al.  A multidisciplinary intervention to prevent the readmission of elderly patients with congestive heart failure. , 1995, The New England journal of medicine.

[26]  A. L. Dal-Fabbro,et al.  Adherence to long term therapies: evidence for action , 2005 .

[27]  Jeffrey A. Johnson,et al.  Using Focus Groups to Identify Barriers to Drug Use in Patients with Congestive Heart Failure , 2000, Pharmacotherapy.

[28]  T. MacDonald,et al.  Nonadherence with ACE inhibitors is common and can be detected in clinical practice by routine serum ACE activity. , 2001, Congestive heart failure.

[29]  O. Shoheiber,et al.  Adherence to antihypertensive therapy with fixed-dose amlodipine besylate/benazepril HCl versus comparable component-based therapy. , 2003, Congestive heart failure.

[30]  L Goldman,et al.  Factors contributing to the hospitalization of patients with congestive heart failure. , 1997, American journal of public health.

[31]  M. Kronenberg,et al.  Pilot study of a Web-based compliance monitoring device for patients with congestive heart failure. , 2003, Heart & lung : the journal of critical care.

[32]  B. Riegel,et al.  Negotiating Compliance in Heart Failure: Remaining Issues and Questions , 2005, European journal of cardiovascular nursing : journal of the Working Group on Cardiovascular Nursing of the European Society of Cardiology.

[33]  R Brian Haynes,et al.  Helping patients follow prescribed treatment: clinical applications. , 2002, JAMA.

[34]  H. Krumholz,et al.  Difficulty taking medications, depression, and health status in heart failure patients. , 2006, Journal of cardiac failure.

[35]  L L Kupper,et al.  Communication, compliance, and concordance between physicians and patients with prescribed medications. , 1976, American journal of public health.

[36]  R. Carney,et al.  Major depression and medication adherence in elderly patients with coronary artery disease. , 1995, Health psychology : official journal of the Division of Health Psychology, American Psychological Association.

[37]  N. Miller,et al.  Compliance with treatment regimens in chronic asymptomatic diseases. , 1997, The American journal of medicine.

[38]  S. Piñeros,et al.  Adherence with statin therapy in secondary prevention of coronary heart disease in veterans administration male population. , 2003, The American journal of cardiology.

[39]  J. Birt,et al.  Medication Compliance in Elderly Outpatients Using Twice-Daily Dosing and Unit-of-Use Packaging , 1993, The Annals of pharmacotherapy.

[40]  K. Bhagat,et al.  Compliance with medication in patients with heart failure in Zimbabwe. , 2001, East African medical journal.

[41]  K. Dracup,et al.  A closer look at compliance research in heart failure patients in the last decade. , 2000, Progress in cardiovascular nursing.

[42]  B. Svarstad,et al.  The Brief Medication Questionnaire: a tool for screening patient adherence and barriers to adherence. , 1999, Patient education and counseling.

[43]  Diederick E Grobbee,et al.  Public awareness of heart failure in Europe: first results from SHAPE. , 2005, European heart journal.

[44]  I. Keber,et al.  Patient's View of Heart Failure: From the Understanding to the Quality of Life , 2003, European journal of cardiovascular nursing : journal of the Working Group on Cardiovascular Nursing of the European Society of Cardiology.

[45]  A. Fendrick,et al.  Suboptimal statin adherence and discontinuation in primary and secondary prevention populations , 2004, Journal of General Internal Medicine.

[46]  D. Brockopp,et al.  Characteristics and treatment of patients with heart failure in the emergency department. , 2002, Journal of emergency nursing: JEN : official publication of the Emergency Department Nurses Association.

[47]  V. T. Nagy,et al.  Cognitive Predictors of Compliance in Chronic Disease Patients , 1984, Medical care.

[48]  E A Graveley,et al.  Multiple drug regimens: medication compliance among veterans 65 years and older. , 1991, Research in nursing & health.

[49]  T. MacDonald,et al.  Non-adherence with ACE inhibitor treatment is common in heart failure and can be detected by routine serum ACE activity assays , 1999, Heart.

[50]  R. Schulz,et al.  Drug use behavior under the constraints of a Medicaid prescription cap. , 1995, Clinical therapeutics.

[51]  Chris J Bonner,et al.  Medication compliance problems in general practice: detection and intervention by pharmacists and doctors. , 2002, The Australian journal of rural health.

[52]  J. George,et al.  Predictors of refill non-adherence in patients with heart failure. , 2007, British journal of clinical pharmacology.

[53]  K. Furie,et al.  Heart disease and stroke statistics--2007 update: a report from the American Heart Association Statistics Committee and Stroke Statistics Subcommittee. , 2008, Circulation.

[54]  L. Matowe,et al.  Unaffordable drug prices: the major cause of non-compliance with hypertension medication in Ghana. , 2004, Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques.

[55]  Gordon Guyatt,et al.  Pilot study to determine the impact of a multidisciplinary educational intervention in patients hospitalized with heart failure. , 2005, American heart journal.

[56]  M. Dimatteo,et al.  Depression is a risk factor for noncompliance with medical treatment: meta-analysis of the effects of anxiety and depression on patient adherence. , 2000, Archives of internal medicine.

[57]  Rodgers Pt,et al.  Medication nonadherence: Part II--A pilot study in patients with congestive heart failure. , 1998 .

[58]  K. Dracup,et al.  Relationship between psychosocial variables and compliance in patients with heart failure. , 2001, Heart & lung : the journal of critical care.

[59]  S. Sereika,et al.  Medication Adherence in Persons With Cardiovascular Disease , 2003, The Journal of cardiovascular nursing.

[60]  J. Avorn,et al.  Noncompliance with antihypertensive medications: the impact of depressive symptoms and psychosocial factors. , 2002, Journal of general internal medicine.

[61]  T. Peters,et al.  Adherence to long-term therapies: recent WHO report provides some answers but poses even more questions. , 2004, Journal of clinical epidemiology.

[62]  Melissa M Deer,et al.  Association Between Adherence to Diuretic Therapy and Health Care Utilization in Patients with Heart Failure , 2003, Pharmacotherapy.

[63]  T. Nikolaus,et al.  Elderly patients' problems with medication , 2004, European Journal of Clinical Pharmacology.

[64]  M. Rich,et al.  Effect of a multidisciplinary intervention on medication compliance in elderly patients with congestive heart failure. , 1996, The American journal of medicine.

[65]  Ann S. Laramee,et al.  Case management in a heterogeneous congestive heart failure population: a randomized controlled trial. , 2003, Archives of internal medicine.

[66]  L. Erhardt,et al.  Non‐compliance and knowledge of prescribed medication in elderly patients with heart failure , 1999, European journal of heart failure.

[67]  Tiny Jaarsma,et al.  Compliance in heart failure patients: the importance of knowledge and beliefs. , 2006, European heart journal.

[68]  A. Walker,et al.  Drug Copayment and Adherence in Chronic Heart Failure: Effect on Cost and Outcomes , 2006, Pharmacotherapy.

[69]  I Heszen-Klemens,et al.  Doctor-patient interaction, patients' health behavior and effects of treatment. , 1984, Social science & medicine.

[70]  J. Chan,et al.  Association between adherence to statin therapy and lipid control in Hong Kong Chinese patients at high risk of coronary heart disease. , 2004, British journal of clinical pharmacology.

[71]  J. Herlitz,et al.  When is a patient with heart failure adequately informed? A study of patients' knowledge of and attitudes toward medical information. , 2004, Heart & lung : the journal of critical care.

[72]  J. Butler,et al.  Outpatient utilization of angiotensin-converting enzyme inhibitors among heart failure patients after hospital discharge. , 2003, Journal of the American College of Cardiology.

[73]  R. Miller,et al.  Quantifying non-compliance in patients receiving digoxin--a pharmacokinetic approach. , 1991, South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde.

[74]  P. Fishman,et al.  Prescription Drug Coverage, Health, and Medication Acquisition Among Seniors With One or More Chronic Conditions , 2004, Medical care.

[75]  J. Lupón,et al.  Nurse Evaluation of Patients in a New Multidisciplinary Heart Failure Unit in Spain , 2004, European journal of cardiovascular nursing : journal of the Working Group on Cardiovascular Nursing of the European Society of Cardiology.

[76]  A. Hoes,et al.  Effect of a pharmacist-led intervention on diuretic compliance in heart failure patients: a randomized controlled study. , 2003, Journal of cardiac failure.