Effect of heat and mass transfer on non-Newtonian flow – Links to atherosclerosis

The present investigation deals with a mathematical model representing the dynamic response of heat and mass transfer to blood streaming through the arteries under stenotic condition. The blood is treated to be a generalized Newtonian fluid and the arterial wall is considered to be rigid having differently shaped stenoses in its lumen arising from various types of abnormal growth or plaque formation. The nonlinear unsteady pulsatile flow phenomenon unaffected by the concentration-field of the macromolecules is governed by the Navier–Stokes equations together with the equation of continuity while those of the heat and the mass transfers are controlled by the heat conduction and the convection–diffusion equations, respectively. The governing equations of motion accompanied by the appropriate choice of the boundary conditions are solved numerically by Marker and Cell (MAC) method in order to compute the physiologically significant quantities with desired degree of accuracy. The necessary checking for numerical stability has been incorporated in the algorithm for better precision of the results computed. The quantitative analysis carried out finally includes the respective profiles of the flow-field, the temperature and the mass concentration along with their individual distributions over the entire arterial segment as well. The key factors like the wall shear stress and the Sherwood number are also examined for further qualitative insight into the heat flow and mass transport phenomena through arterial stenosis. The present results show quite consistency with several existing results in the literature which substantiate sufficiently to validate the applicability of the model under consideration.

[1]  R. Ross,et al.  Rous-Whipple Award Lecture. Atherosclerosis: a defense mechanism gone awry. , 1993, The American journal of pathology.

[2]  E F Halpern,et al.  Radio-frequency tissue ablation: effect of pharmacologic modulation of blood flow on coagulation diameter. , 1998, Radiology.

[3]  H. A. Attia,et al.  Magnetohydrodynamic flow and heat transfer of a non-Newtonian fluid in an eccentric annulus , 1998 .

[4]  S. Charm,et al.  Heat transfer coefficients in blood flow. , 1968, Biorheology.

[5]  J. Lagendijk The influence of bloodflow in large vessels on the temperature distribution in hyperthermia. , 1982, Physics in medicine and biology.

[6]  T. Winter,et al.  Effect of vascular occlusion on radiofrequency ablation of the liver: results in a porcine model. , 2001, AJR. American journal of roentgenology.

[7]  V. L. Shah,et al.  Steady state heat transfer to blood flowing in the entrance region of a tube , 1976 .

[8]  Michael C. Kolios,et al.  Large blood vessel cooling in heated tissues: a numerical study. , 1995, Physics in medicine and biology.

[9]  J. R. Radbill,et al.  Analysis of oxygen transport from pulsatile viscous blood flow to diseased coronary arteries of man. , 1977, Journal of biomechanics.

[10]  R. Nerem Vascular fluid mechanics, the arterial wall, and atherosclerosis. , 1992, Journal of biomechanical engineering.

[11]  C. W. Hirt Heuristic stability theory for finite-difference equations☆ , 1968 .

[12]  Y. Kawase,et al.  Heat and mass transfer in non-newtonian fluid flow with power function velocity profiles , 1983 .

[13]  S T Clegg,et al.  Pulsatile blood flow effects on temperature distribution and heat transfer in rigid vessels. , 2001, Journal of biomechanical engineering.

[14]  D. Ku,et al.  Pulsatile Flow and Atherosclerosis in the Human Carotid Bifurcation: Positive Correlation between Plaque Location and Low and Oscillating Shear Stress , 1985, Arteriosclerosis.

[15]  R C Schroter,et al.  Proposal of a shear dependent mass transfer mechanism for atherogenesis. , 1971, Clinical science.

[16]  C. R. Ethier,et al.  Intimal Thickness Is not Associated With Wall Shear Stress Patterns in the Human Right Coronary Artery , 2004, Arteriosclerosis, thrombosis, and vascular biology.

[17]  R. Guidoin,et al.  Uptake of 3H-7-Cholesterol Along the Arterial Wall at an Area of Stenosis , 1994, ASAIO journal.

[18]  K Perktold,et al.  Computer simulation of convective diffusion processes in large arteries. , 1996, Journal of biomechanics.

[19]  G. Hutchins,et al.  Correlation between intimal thickness and fluid shear in human arteries. , 1981, Atherosclerosis.

[20]  J C Chato,et al.  Heat transfer to blood vessels. , 1980, Journal of biomechanical engineering.

[21]  H. Andersson,et al.  Effects of surface irregularities on flow resistance in differently shaped arterial stenoses. , 2000, Journal of biomechanics.

[22]  D W Crawford,et al.  Effect of mild atherosclerosis on flow resistance in a coronary artery casting of man. , 1984, Journal of biomechanical engineering.

[23]  V. G. Ferreira,et al.  The MAC method , 2008 .

[24]  A. A. Amsden,et al.  The SMAC method: A numerical technique for calculating incompressible fluid flow , 1970 .

[25]  G. Barozzi,et al.  Convective heat transfer coefficients in the circulation. , 1991, Journal of biomechanical engineering.

[26]  C. Hung,et al.  Flow of non-Newtonian fluid in the entrance region of a tube with porous walls , 1991 .

[27]  S A Victor,et al.  High transfer to blood flowing in a tube. , 1975, Biorheology.

[28]  B. Rutt,et al.  Reconstruction of carotid bifurcation hemodynamics and wall thickness using computational fluid dynamics and MRI , 2002, Magnetic resonance in medicine.

[29]  J. G. Webster,et al.  Hepatic bipolar radiofrequency ablation creates coagulation zones close to blood vessels: A finite element study , 2003, Medical and Biological Engineering and Computing.

[30]  C. R. Ethier,et al.  Computational Modeling of Mass Transfer and Links to Atherosclerosis , 2002, Annals of Biomedical Engineering.

[31]  M. Kaazempur-Mofrad,et al.  Characterization of the Atherosclerotic Carotid Bifurcation Using MRI, Finite Element Modeling, and Histology , 2004, Annals of Biomedical Engineering.

[32]  D Kilpatrick,et al.  Mathematical modelling of flow through an irregular arterial stenosis. , 1991, Journal of biomechanics.

[33]  C Ross Ethier,et al.  Computational analysis of coupled blood-wall arterial LDL transport. , 2002, Journal of biomechanical engineering.

[34]  Hong Cao,et al.  Three-dimensional finite-element analyses for radio-frequency hepatic tumor ablation , 2002, IEEE Trans. Biomed. Eng..

[35]  L. Grinberg,et al.  Modeling rough stenoses by an immersed-boundary method. , 2005, Journal of biomechanics.

[36]  R. Schroter,et al.  Atheroma and arterial wall shear - Observation, correlation and proposal of a shear dependent mass transfer mechanism for atherogenesis , 1971, Proceedings of the Royal Society of London. Series B. Biological Sciences.

[37]  David N. Ku,et al.  Heat and mass transfer in a separated flow region for high Prandtl and Schmidt numbers under pulsatile conditions , 1994 .

[38]  D. Ku,et al.  Fluid mechanics of vascular systems, diseases, and thrombosis. , 1999, Annual review of biomedical engineering.