Involvement of tyrosine kinases and STAT3 in Humanin-mediated neuroprotection.

[1]  W. Gong,et al.  Humanin, a Newly Identified Neuroprotective Factor, Uses the G Protein-Coupled Formylpeptide Receptor-Like-1 as a Functional Receptor1 , 2004, The Journal of Immunology.

[2]  D. Harrison,et al.  The JAK/STAT signaling pathway , 2004, Journal of Cell Science.

[3]  I. Nishimoto,et al.  Unravelling the role of Humanin. , 2004, Trends in molecular medicine.

[4]  B. Kriem,et al.  Humanin rescues cortical neurons from prion-peptide-induced apoptosis , 2004, Molecular and Cellular Neuroscience.

[5]  S. Ueno,et al.  Humanin improves impaired metabolic activity and prolongs survival of serum-deprived human lymphocytes , 2003, Molecular and Cellular Biochemistry.

[6]  H. Weiner,et al.  Immunotherapeutic Approaches to Alzheimer's Disease , 2003, Science.

[7]  I. Nishimoto,et al.  The Cytoplasmic Domain of Alzheimer's Amyloid-β Protein Precursor Causes Sustained Apoptosis Signal-Regulating Kinase 1/c-Jun NH2-Terminal Kinase-Mediated Neurotoxic Signal via Dimerization , 2003, Journal of Pharmacology and Experimental Therapeutics.

[8]  I. Nishimoto,et al.  Characterization of the toxic mechanism triggered by Alzheimer's amyloid‐β peptides via p75 neurotrophin receptor in neuronal hybrid cells , 2003, Journal of neuroscience research.

[9]  S. Meloche,et al.  Rho Family GTPases Are Required for Activation of Jak/STAT Signaling by G Protein-Coupled Receptors , 2003, Molecular and Cellular Biology.

[10]  W. V. Van Nostrand,et al.  Humanin rescues human cerebrovascular smooth muscle cells from Aβ‐induced toxicity , 2003, Journal of neurochemistry.

[11]  J. Hardy,et al.  The Amyloid Hypothesis of Alzheimer ’ s Disease : Progress and Problems on the Road to Therapeutics , 2009 .

[12]  S. Kariya,et al.  Humanin inhibits cell death of serum-deprived PC12h cells , 2002, Neuroreport.

[13]  I. Nishimoto,et al.  Neurotoxic mechanisms triggered by Alzheimer's disease‐linked mutant M146L presenilin 1: involvement of NO synthase via a novel pertussis toxin target , 2002, Journal of neurochemistry.

[14]  I. Nishimoto,et al.  Detailed Characterization of Neuroprotection by a Rescue Factor Humanin against Various Alzheimer's Disease-Relevant Insults , 2001, The Journal of Neuroscience.

[15]  G. Sobue,et al.  A rescue factor abolishing neuronal cell death by a wide spectrum of familial Alzheimer's disease genes and Aβ , 2001, Proceedings of the National Academy of Sciences of the United States of America.

[16]  T. Hiraki,et al.  Secreted Aβ Does Not Mediate Neurotoxicity by Antibody-Stimulated Amyloid Precursor Protein , 2001 .

[17]  W. Shen,et al.  Amyloid β42 Activates a G-Protein-Coupled Chemoattractant Receptor, FPR-Like-1 , 2001, The Journal of Neuroscience.

[18]  J. Turkson,et al.  STAT proteins: novel molecular targets for cancer drug discovery , 2000, Oncogene.

[19]  I. Nishimoto,et al.  Multiple Mechanisms Underlie Neurotoxicity by Different Types of Alzheimer's Disease Mutations of Amyloid Precursor Protein* , 2000, The Journal of Biological Chemistry.

[20]  C. Cotman,et al.  A Monoclonal Antibody to Amyloid Precursor Protein Induces Neuronal Apoptosis , 2000, Journal of neurochemistry.

[21]  D K Ingram,et al.  Death of PC12 cells and hippocampal neurons induced by adenoviral‐mediated FAD human amyloid precursor protein gene expression , 1999, Journal of neuroscience research.

[22]  B. Shastry,et al.  Genes and susceptible loci of Alzheimer’s disease , 1999, Brain Research Bulletin.

[23]  H. Okamura,et al.  Degeneration In Vivo of Rat Hippocampal Neurons by Wild-Type Alzheimer Amyloid Precursor Protein Overexpressed by Adenovirus-Mediated Gene Transfer , 1998, The Journal of Neuroscience.

[24]  W. Horton,et al.  Expression of mutant amyloid precursor proteins induces apoptosis in PC12 cells , 1997, Journal of neuroscience research.

[25]  T. Sunderland,et al.  Participation of Presenilin 2 in Apoptosis: Enhanced Basal Activity Conferred by an Alzheimer Mutation , 1996, Science.

[26]  S. Takeda,et al.  G Protein-Mediated Neuronal DNA Fragmentation Induced by Familial Alzheimer's Disease-Associated Mutants of APP , 1996, Science.

[27]  S. Akira,et al.  STAT3 activation is a critical step in gp130-mediated terminal differentiation and growth arrest of a myeloid cell line. , 1996, Proceedings of the National Academy of Sciences of the United States of America.

[28]  S. Takeda,et al.  Expression of V642 APP mutant causes cellular apoptosis as Alzheimer trait‐linked phenotype. , 1996, The EMBO journal.

[29]  C. Cotman,et al.  Apoptosis is induced by beta-amyloid in cultured central nervous system neurons. , 1993, Proceedings of the National Academy of Sciences of the United States of America.

[30]  I. Nishimoto,et al.  Alzheimer amyloid protein precursor complexes with brain GTP-binding protein Go , 1993, Nature.

[31]  K. Marder,et al.  Codon 618 variant of alzheimer amyloid gene associated with inherited cerebral hemorrhage , 1991, Annals of neurology.