Metabolism and the heart: an overview of muscle, fat, and bone metabolism in heart failure.

[1]  Brown Wv.  Framingham Heart Study. , 2011, Journal of clinical lipidology.

[2]  S. Haehling,et al.  The Obesity Paradox in Heart Failure: Accepting Reality and Making Rational Decisions , 2011, Clinical pharmacology and therapeutics.

[3]  J. Ketelslegers,et al.  Increased plasma myostatin in heart failure , 2011, European journal of heart failure.

[4]  C. Vrints,et al.  Exercise training reverses adiponectin resistance in skeletal muscle of patients with chronic heart failure , 2011, Heart.

[5]  F. Dioguardi.  Clinical use of amino acids as dietary supplement: pros and cons , 2011, Journal of cachexia, sarcopenia and muscle.

[6]  S. Anker,et al.  Myopenia—a new universal term for muscle wasting , 2011, Journal of cachexia, sarcopenia and muscle.

[7]  S. Anker,et al.  Revisiting the obesity paradox in heart failure: new insights? , 2011, European journal of heart failure.

[8]  P. Pfluger,et al.  Ghrelin and its potential in the treatment of eating/wasting disorders and cachexia , 2010, Journal of cachexia, sarcopenia and muscle.

[9]  P. Ponikowski,et al.  Diabetes mellitus, cachexia and obesity in heart failure: rationale and design of the Studies Investigating Co-morbidities Aggravating Heart Failure (SICA-HF) , 2010, Journal of cachexia, sarcopenia and muscle.

[10]  D. Marks,et al.  Pathophysiology and treatment of inflammatory anorexia in chronic disease , 2010, Journal of cachexia, sarcopenia and muscle.

[11]  Stephan von Haehling,et al.  An overview of sarcopenia: facts and numbers on prevalence and clinical impact , 2010, Journal of cachexia, sarcopenia and muscle.

[12]  T. Akamizu,et al.  Ghrelin for cachexia , 2010, Journal of cachexia, sarcopenia and muscle.

[13]  A. Vigano,et al.  Cancer-related fatigue: the impact of skeletal muscle mass and strength in patients with advanced cancer , 2010, Journal of cachexia, sarcopenia and muscle.

[14]  S. Anker,et al.  Advances in understanding and treating cardiac cachexia: highlights from the 5th Cachexia Conference. , 2010, International journal of cardiology.

[15]  A. Coats,et al.  Ethics in the authorship and publishing of scientific articles , 2010 .

[16]  Stephan von Haehling,et al.  Cachexia as a major underestimated and unmet medical need: facts and numbers , 2010, Journal of cachexia, sarcopenia and muscle.

[17]  G. Schuler,et al.  Skeletal muscle wasting in cachexia and sarcopenia: molecular pathophysiology and impact of exercise training , 2010, Journal of cachexia, sarcopenia and muscle.

[18]  J. Lupón,et al.  Niveles séricos de miostatina en insuficiencia cardiaca crónica , 2010 .

[19]  C. Petrilli,et al.  Myostatin activation in patients with advanced heart failure and after mechanical unloading , 2010, European journal of heart failure.

[20]  Z. Radojicic,et al.  Relationship between high circulating adiponectin with bone mineral density and bone metabolism in elderly males with chronic heart failure. , 2010, Journal of cardiac failure.

[21]  C. Rubin,et al.  Dynamic skeletal muscle stimulation and its potential in bone adaptation. , 2010, Journal of musculoskeletal & neuronal interactions.

[22]  K. Okoshi,et al.  Myostatin and follistatin expression in skeletal muscles of rats with chronic heart failure , 2010, International journal of experimental pathology.

[23]  S. Welle,et al.  Genetic Deletion of Myostatin From the Heart Prevents Skeletal Muscle Atrophy in Heart Failure , 2010, Circulation.

[24]  S. Anker,et al.  Myostatin Regulator of Muscle Wasting in Heart Failure and Treatment Target for Cardiac Cachexia , 2010 .

[25]  J. Lupón,et al.  Serum myostatin levels in chronic heart failure. , 2010, Revista espanola de cardiologia.

[26]  J. Rutledge,et al.  Chronic high fat feeding attenuates load‐induced hypertrophy in mice , 2009, The Journal of physiology.

[27]  S. Anker,et al.  No effects of human ghrelin on cardiac function despite profound effects on body composition in a rat model of heart failure. , 2009, International journal of cardiology.

[28]  G. Karsenty,et al.  A paradigm of integrative physiology, the crosstalk between bone and energy metabolisms , 2009, Molecular and Cellular Endocrinology.

[29]  A. Abou-Raya,et al.  Osteoporosis and congestive heart failure (CHF) in the elderly patient: double disease burden. , 2009, Archives of gerontology and geriatrics.

[30]  F. Planas,et al.  Relationship Between Adiponectin and Left Atrium Size in Uncomplicated Obese Patients: Adiponectin, a Link Between Fat and Heart , 2009, Obesity surgery.

[31]  J. Kaufman,et al.  Fat mass is negatively associated with cortical bone size in young healthy male siblings. , 2009, The Journal of clinical endocrinology and metabolism.

[32]  T. Funahashi,et al.  Natriuretic peptides enhance the production of adiponectin in human adipocytes and in patients with chronic heart failure. , 2009, Journal of the American College of Cardiology.

[33]  A. Ferreira,et al.  Adiponectin is increased in cardiac cachexia irrespective of body mass index , 2009, European journal of heart failure.

[34]  C. Lavie,et al.  Obesity and cardiovascular disease: risk factor, paradox, and impact of weight loss. , 2009, Journal of the American College of Cardiology.

[35]  A. Miján-de-la-Torre.  Recent insights on chronic heart failure, cachexia and nutrition , 2009, Current opinion in clinical nutrition and metabolic care.

[36]  P. Erne,et al.  Cardiac computed tomography for the diagnosis of right ventricular implantable cardioverter-defibrillator lead perforation. , 2009, European heart journal.

[37]  G. Schuler,et al.  Impact of exercise training on myostatin expression in the myocardium and skeletal muscle in a chronic heart failure model , 2009, European journal of heart failure.

[38]  S. Anker,et al.  Cardiac cachexia: a systematic overview. , 2009, Pharmacology & therapeutics.

[39]  P. Ponikowski,et al.  Bone mineral status and bone loss over time in men with chronic systolic heart failure and their clinical and hormonal determinants , 2009, European journal of heart failure.

[40]  F. McAlister,et al.  Heart Failure Is a Risk Factor for Orthopedic Fracture: A Population-Based Analysis of 16 294 Patients , 2008, Circulation.

[41]  Salim Yusuf,et al.  Weight loss and mortality risk in patients with chronic heart failure in the candesartan in heart failure: assessment of reduction in mortality and morbidity (CHARM) programme. , 2008, European heart journal.

[42]  M. Febbraio,et al.  Muscle as an endocrine organ: focus on muscle-derived interleukin-6. , 2008, Physiological reviews.

[43]  A. Benetos,et al.  Effects of lean and fat mass on bone mineral density and arterial stiffness in elderly men , 2008, Osteoporosis International.

[44]  J. Bailey,et al.  Beyond nutrition: neuropeptide signaling and muscle mass maintenance in chronic kidney disease. , 2008, Kidney international.

[45]  C. Opasich,et al.  Oral amino acid supplements improve exercise capacities in elderly patients with chronic heart failure. , 2008, The American journal of cardiology.

[46]  D. Allen,et al.  Myostatin, activin receptor IIb, and follistatin-like-3 gene expression are altered in adipose tissue and skeletal muscle of obese mice. , 2008, American journal of physiology. Endocrinology and metabolism.

[47]  S. Anker,et al.  The cholesterol paradox revisited: heart failure, systemic inflammation, and beyond. , 2008, Heart failure clinics.

[48]  M. Horie,et al.  Effect of atrial natriuretic peptide on adiponectin in patients with heart failure , 2008, European journal of heart failure.

[49]  A. Sandek,et al.  The endotoxin-lipoprotein hypothesis – an update , 2008 .

[50]  T. Travison,et al.  Lean Mass and Not Fat Mass Is Associated With Male Proximal Femur Strength , 2007, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[51]  M. Cheitlin.  Body Mass Index and Prognosis in Patients With Chronic Heart Failure: Insights From the Candesartan in Heart failure: Assessment of Reduction in Mortality and morbidity (CHARM) Program , 2008 .

[52]  M. Hamrick,et al.  Leptin and the sympathetic connection of fat to bone , 2008, Osteoporosis International.

[53]  M. McKee,et al.  Endocrine Regulation of Energy Metabolism by the Skeleton , 2007, Cell.

[54]  S. Solomon,et al.  Body Mass Index and Prognosis in Patients With Chronic Heart Failure: Insights From the Candesartan in Heart failure: Assessment of Reduction in Mortality and morbidity (CHARM) Program , 2007, Circulation.

[55]  A. Negassa,et al.  Heart transplantation in heart failure: The prognostic importance of body mass index at time of surgery and subsequent weight changes , 2007, European journal of heart failure.

[56]  R. Kloner,et al.  Alterations in myostatin expression are associated with changes in cardiac left ventricular mass but not ejection fraction in the mouse. , 2007, The Journal of endocrinology.

[57]  Takeshi Kimura,et al.  Serum adiponectin level as an independent predictor of mortality in patients with congestive heart failure. , 2007, Circulation journal : official journal of the Japanese Circulation Society.

[58]  B. Pedersen,et al.  Beneficial health effects of exercise--the role of IL-6 as a myokine. , 2007, Trends in pharmacological sciences.

[59]  J. McMurray,et al.  Increase in serum adiponectin concentration in patients with heart failure and cachexia: relationship with leptin, other cytokines, and B-type natriuretic peptide. , 2007, European heart journal.

[60]  R. Frost,et al.  Effects of calcium supplementation on bone loss and fractures in congestive heart failure. , 2007, European journal of endocrinology.

[61]  Stephan von Haehling,et al.  Nutrition, metabolism, and the complex pathophysiology of cachexia in chronic heart failure. , 2007, Cardiovascular research.

[62]  藤岡 大佑.  Role of adiponectin receptors in endothelin-induced cellular hypertrophy in cultured cardiomyocytes and their expression in infarcted heart , 2007 .

[63]  U. Wisløff,et al.  Myocardial expression of Murf-1 and MAFbx after induction of chronic heart failure: Effect on myocardial contractility. , 2007, Cardiovascular research.

[64]  N. Viguerie,et al.  Role of adipokines in the control of energy metabolism: focus on adiponectin. , 2006, Current opinion in pharmacology.

[65]  D. Attaix,et al.  Mechanisms of skeletal muscle atrophy , 2006, Current opinion in rheumatology.

[66]  K. Shyu,et al.  Myostatin expression in ventricular myocardium in a rat model of volume‐overload heart failure , 2006, European journal of clinical investigation.

[67]  H. Xie,et al.  Adiponectin Stimulates RANKL and Inhibits OPG Expression in Human Osteoblasts Through the MAPK Signaling Pathway , 2006, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[68]  S. Anker,et al.  The need for a standardized definition for cachexia in chronic illness , 2006, Nature Clinical Practice Endocrinology &Metabolism.

[69]  S. Cook,et al.  Myostatin Regulates Cardiomyocyte Growth Through Modulation of Akt Signaling , 2006, Circulation research.

[70]  A. Kenny,et al.  Femoral bone mineral density in patients with heart failure , 2006, Osteoporosis International.

[71]  Y. Sharabi,et al.  Circulating adiponectin concentrations in patients with congestive heart failure , 2006, Heart.

[72]  R. Koerfer,et al.  Markers of bone metabolism in congestive heart failure. , 2006, Clinica chimica acta; international journal of clinical chemistry.

[73]  Wei-Shiung Yang,et al.  Insulin-like growth factor-1 mediates stretch-induced upregulation of myostatin expression in neonatal rat cardiomyocytes. , 2005, Cardiovascular research.

[74]  S. Anker,et al.  Muscle wasting in cardiac cachexia. , 2005, The international journal of biochemistry & cell biology.

[75]  H. Xie,et al.  Adiponectin stimulates human osteoblasts proliferation and differentiation via the MAPK signaling pathway. , 2005, Experimental cell research.

[76]  J. Argilés,et al.  Interleukin‐15 stimulates adiponectin secretion by 3T3‐L1 adipocytes: Evidence for a skeletal muscle‐to‐fat signaling pathway , 2005, Cell biology international.

[77]  H. Kroger,et al.  Body mass index as a predictor of fracture risk: A meta-analysis , 2005, Osteoporosis International.

[78]  S. Majumdar,et al.  Development and Initial Validation of a Risk Score for Predicting In‐Hospital and 1‐Year Mortality in Patients With Hip Fractures , 2004, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[79]  H. Krumholz,et al.  The obesity paradox: body mass index and outcomes in patients with heart failure. , 2005, Archives of internal medicine.

[80]  WataruShimizu,et al.  Effects of Ghrelin Administration on Left Ventricular Function, Exercise Capacity, and Muscle Wasting in Patients With Chronic Heart Failure , 2004 .

[81]  W. Frontera,et al.  IKKβ/NF-κB Activation Causes Severe Muscle Wasting in Mice , 2004, Cell.

[82]  Se-Jin Lee.  Regulation of muscle mass by myostatin. , 2004, Annual review of cell and developmental biology.

[83]  S. Kandarian,et al.  The molecular basis of skeletal muscle atrophy. , 2004, American journal of physiology. Cell physiology.

[84]  L. D. Libera,et al.  Muscle wastage in chronic heart failure, between apoptosis, catabolism and altered anabolism: a chimaeric view of inflammation? , 2004, Current opinion in clinical nutrition and metabolic care.

[85]  M. Febbraio,et al.  Interleukin-6 and insulin sensitivity: friend or foe? , 2004, Diabetologia.

[86]  R. Ahima,et al.  Adiponectin acts in the brain to decrease body weight , 2004, Nature Medicine.

[87]  Andrew D. Williams,et al.  Reduced exercise tolerance in CHF may be related to factors other than impaired skeletal muscle oxidative capacity. , 2004, Journal of cardiac failure.

[88]  Stephan von Haehling,et al.  Inflammatory mediators in chronic heart failure: an overview , 2004, Heart.

[89]  W. Frontera,et al.  IKKbeta/NF-kappaB activation causes severe muscle wasting in mice. , 2004, Cell.

[90]  S. Anker,et al.  The relationship between cholesterol and survival in patients with chronic heart failure. , 2003, Journal of the American College of Cardiology.

[91]  S. Anker,et al.  Tumour necrosis factor-α and the failing heart , 2003, Basic Research in Cardiology.

[92]  A. Negassa,et al.  Prognostic importance of weight loss in chronic heart failure and the effect of treatment with angiotensin-converting-enzyme inhibitors: an observational study☆ , 2003 .

[93]  Christopher J. Lyon,et al.  Minireview: adiposity, inflammation, and atherogenesis. , 2003, Endocrinology.

[94]  C. Lavie,et al.  Body composition and prognosis in chronic systolic heart failure: the obesity paradox. , 2002, The American journal of cardiology.

[95]  D. Malan,et al.  Ghrelin and des-acyl ghrelin inhibit cell death in cardiomyocytes and endothelial cells through ERK1/2 and PI 3-kinase/AKT , 2002, The Journal of cell biology.

[96]  J. Murabito,et al.  Lifetime Risk for Developing Congestive Heart Failure: The Framingham Heart Study , 2002, Circulation.

[97]  I. Reid.  Relationships among body mass, its components, and bone. , 2002, Bone.

[98]  M. Iida,et al.  Central Ghrelin Modulates Sympathetic Activity in Conscious Rabbits , 2002, Hypertension.

[99]  S. Anker,et al.  Cachexia: a therapeutic approach beyond cytokine antagonism. , 2002, International journal of cardiology.

[100]  G. Fonarow,et al.  Low serum total cholesterol is associated with marked increase in mortality in advanced heart failure. , 2002, Journal of cardiac failure.

[101]  J. Eisman,et al.  Good, good, good… good vibrations: the best option for better bones? , 2001, The Lancet.

[102]  W. Shimizu,et al.  Elevated Circulating Level of Ghrelin in Cachexia Associated With Chronic Heart Failure: Relationships Between Ghrelin and Anabolic/Catabolic Factors , 2001, Circulation.

[103]  K. Chihara,et al.  Plasma leptin concentrations are associated with bone mineral density and the presence of vertebral fractures in postmenopausal women , 2001, Clinical endocrinology.

[104]  G. Fonarow,et al.  The relationship between obesity and mortality in patients with heart failure. , 2001, Journal of the American College of Cardiology.

[105]  Se-Jin Lee,et al.  Regulation of myostatin activity and muscle growth , 2001, Proceedings of the National Academy of Sciences of the United States of America.

[106]  M. Cicoira,et al.  Skeletal muscle mass independently predicts peak oxygen consumption and ventilatory response during exercise in noncachectic patients with chronic heart failure. , 2001, Journal of the American College of Cardiology.

[107]  S Capewell,et al.  More ‘malignant’ than cancer? Five‐year survival following a first admission for heart failure , 2001, European journal of heart failure.

[108]  H K Genant,et al.  Structural Adaptation to Changing Skeletal Load in the Progression Toward Hip Fragility: The Study of Osteoporotic Fractures , 2001, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[109]  H. Lodish,et al.  Proteolytic cleavage product of 30-kDa adipocyte complement-related protein increases fatty acid oxidation in muscle and causes weight loss in mice. , 2001, Proceedings of the National Academy of Sciences of the United States of America.

[110]  K. Swedberg,et al.  Skeletal muscle characteristics, muscle strength and thigh muscle area in patients before and after cardiac transplantation , 2001, European journal of heart failure.

[111]  H. Sievänen,et al.  Bone Mineral Density During Reduction, Maintenance and Regain of Body Weight in Premenopausal, Obese Women , 2001, Osteoporosis International.

[112]  S. Anker,et al.  The endotoxin-lipoprotein hypothesis , 2000, The Lancet.

[113]  S G Thompson,et al.  Survival of patients with a new diagnosis of heart failure: a population based study , 2000, Heart.

[114]  D. Wagner,et al.  The role of tumor necrosis factor in the pathophysiology of heart failure. , 2000, Journal of the American College of Cardiology.

[115]  M. Nakazato,et al.  Ghrelin is a growth-hormone-releasing acylated peptide from stomach , 1999, Nature.

[116]  K. Matthews,et al.  Myostatin, a transforming growth factor‐β superfamily member, is expressed in heart muscle and is upregulated in cardiomyocytes after infarct , 1999, Journal of cellular physiology.

[117]  W. Kraus,et al.  Capillary density of skeletal muscle: a contributing mechanism for exercise intolerance in class II-III chronic heart failure independent of other peripheral alterations. , 1999, Journal of the American College of Cardiology.

[118]  P. Ponikowski,et al.  Cytokines and neurohormones relating to body composition alterations in the wasting syndrome of chronic heart failure. , 1999, European heart journal.

[119]  T Nakamura,et al.  Paradoxical decrease of an adipose-specific protein, adiponectin, in obesity. , 1999, Biochemical and biophysical research communications.

[120]  P. Glendenning,et al.  High prevalence of osteoporosis in cardiac transplant recipients and discordance between biochemical turnover markers and bone histomorphometry , 1999, Clinical endocrinology.

[121]  S. Anker,et al.  Loss of bone mineral in patients with cachexia due to chronic heart failure. , 1999, The American journal of cardiology.

[122]  K. Bailey,et al.  Congestive heart failure in the community: trends in incidence and survival in a 10-year period. , 1999, Archives of internal medicine.

[123]  S. Coppack,et al.  Production of soluble tumor necrosis factor receptors by human subcutaneous adipose tissue in vivo. , 1999, The American journal of physiology.

[124]  A. Goulding,et al.  Plasma Leptin Values in Relation to Bone Mass and Density and to Dynamic Biochemical Markers of Bone Resorption and Formation in Postmenopausal Women , 1998, Calcified Tissue International.

[125]  C. Cooper,et al.  Management of male osteoporosis: report of the UK Consensus Group. , 1998, QJM : monthly journal of the Association of Physicians.

[126]  D. Mancini,et al.  Bone mass, vitamin D deficiency, and hyperparathyroidism in congestive heart failure. , 1997, The American journal of medicine.

[127]  E. Evans,et al.  In vivo validation of whole body composition estimates from dual-energy X-ray absorptiometry. , 1997, Journal of applied physiology.

[128]  Se-Jin Lee,et al.  Regulation of skeletal muscle mass in mice by a new TGF-p superfamily member , 1997, nature.

[129]  P. Ponikowski,et al.  Wasting as independent risk factor for mortality in chronic heart failure , 1997, The Lancet.

[130]  P. Poole‐Wilson,et al.  The influence of muscle mass, strength, fatigability and blood flow on exercise capacity in cachectic and non-cachectic patients with chronic heart failure. , 1997, European heart journal.

[131]  A. Goldberg,et al.  Mechanisms of muscle wasting. The role of the ubiquitin-proteasome pathway. , 1996, The New England journal of medicine.

[132]  L. Melton,et al.  Relationship between body composition and bone mass in women , 1996, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[133]  D. Mancini,et al.  Fracture after cardiac transplantation: a prospective longitudinal study. , 1996, The Journal of clinical endocrinology and metabolism.

[134]  G. Dudley,et al.  Relation of systemic and local muscle exercise capacity to skeletal muscle characteristics in men with congestive heart failure. , 1996, Journal of the American College of Cardiology.

[135]  P. Poole‐Wilson,et al.  Symptoms and quality of life in heart failure: the muscle hypothesis. , 1994, British heart journal.

[136]  D. Felson,et al.  Bone mineral density in elderly men and women: Results from the framingham osteoporosis study , 1992 .

[137]  R. Lenkinski,et al.  Contribution of Skeletal Muscle Atrophy to Exercise Intolerance and Altered Muscle Metabolism in Heart Failure , 1992, Circulation.

[138]  E. Orwoll,et al.  The rate of bone mineral loss in normal men and the effects of calcium and cholecalciferol supplementation. , 1990, Annals of internal medicine.

[139]  P. Knight.  Principles and Practice of Geriatric Medicine , 1987 .

[140]  D. Morgan,et al.  POTASSIUM DEPLETION AND TISSUE LOSS IN CHRONIC HEART-DISEASE , 1979, The Lancet.

[141]  A. Katz,et al.  DISEASE OF THE HEART IN THE WORKS OF HIPPOCRATES , 1962, British heart journal.