The effect of brain lesions on sound localization in complex acoustic environments.

Localizing sound sources of interest in cluttered acoustic environments--as in the 'cocktail-party' situation--is one of the most demanding challenges to the human auditory system in everyday life. In this study, stroke patients' ability to localize acoustic targets in a single-source and in a multi-source setup in the free sound field were directly compared. Subsequent voxel-based lesion-behaviour mapping analyses were computed to uncover the brain areas associated with a deficit in localization in the presence of multiple distracter sound sources rather than localization of individually presented sound sources. Analyses revealed a fundamental role of the right planum temporale in this task. The results from the left hemisphere were less straightforward, but suggested an involvement of inferior frontal and pre- and postcentral areas. These areas appear to be particularly involved in the spectrotemporal analyses crucial for effective segregation of multiple sound streams from various locations, beyond the currently known network for localization of isolated sound sources in otherwise silent surroundings.

[1]  F. Tomaiuolo,et al.  The anatomy of neglect without hemianopia: a key role for parietal–frontal disconnection? , 2003, Neuroreport.

[2]  C. Grady,et al.  “What” and “where” in the human auditory system , 2001, Proceedings of the National Academy of Sciences of the United States of America.

[3]  G. R. Eichhorn,et al.  Neural correlates of naming animals from their characteristic sounds , 2003, Neuropsychologia.

[4]  E. C. Cmm,et al.  on the Recognition of Speech, with , 2008 .

[5]  R. Zatorre,et al.  Where is 'where' in the human auditory cortex? , 2002, Nature Neuroscience.

[6]  S. Weintraub,et al.  Mental state assessment of young and elderly adults in behavioral neurology , 1985 .

[7]  P. Pohl.  Central auditory processing , 1983 .

[8]  Jörg Lewald,et al.  Sound localization with eccentric head position , 2000, Behavioural Brain Research.

[9]  R. Meuli,et al.  Auditory agnosia and auditory spatial deficits following left hemispheric lesions: evidence for distinct processing pathways , 2000, Neuropsychologia.

[10]  Hans-Otto Karnath,et al.  A simple measure of neglect severity , 2010, Neuropsychologia.

[11]  André Brechmann,et al.  Auditory stream segregation relying on timbre involves left auditory cortex , 2004, Neuroreport.

[12]  M. Chait,et al.  Brain Bases for Auditory Stimulus-Driven Figure–Ground Segregation , 2011, The Journal of Neuroscience.

[13]  G. Recanzone,et al.  The biological basis of audition. , 2008, Annual review of psychology.

[14]  Katrin Krumbholz,et al.  Hierarchical processing of sound location and motion in the human brainstem and planum temporale , 2005, The European journal of neuroscience.

[15]  Claude Alain,et al.  Assessing the auditory dual-pathway model in humans , 2004, NeuroImage.

[16]  K. Kiehl,et al.  Neural sources involved in auditory target detection and novelty processing: an event-related fMRI study. , 2001, Psychophysiology.

[17]  L. Gauthier,et al.  The Bells Test: A quantitative and qualitative test for visual neglect. , 1989 .

[18]  H. Duffau,et al.  Direct Evidence for a Parietal-Frontal Pathway Subserving Spatial Awareness in Humans , 2005, Science.

[19]  J. Blauert.  Spatial Hearing: The Psychophysics of Human Sound Localization , 1983 .

[20]  André Brechmann,et al.  Active stream segregation specifically involves the left human auditory cortex , 2010, Hearing Research.

[21]  M. Marcell,et al.  Confrontation Naming of Environmental Sounds , 2000, Journal of clinical and experimental neuropsychology.

[22]  E. Courchesne,et al.  Broca's Area and the Discrimination of Frequency Transitions: A Functional MRI Study , 2001, Brain and Language.

[23]  Alexander Gutschalk,et al.  Activity associated with stream segregation in human auditory cortex is similar for spatial and pitch cues. , 2010, Cerebral cortex.

[24]  David Poeppel,et al.  The analysis of speech in different temporal integration windows: cerebral lateralization as 'asymmetric sampling in time' , 2003, Speech Commun..

[25]  R. Goebel,et al.  The functional neuroanatomy of target detection: an fMRI study of visual and auditory oddball tasks. , 1999, Cerebral cortex.

[26]  D. Pandya,et al.  Segmentation of subcomponents within the superior longitudinal fascicle in humans: a quantitative, in vivo, DT-MRI study. , 2005, Cerebral cortex.

[27]  P. Goldman-Rakic,et al.  Cortical dysfunction in schizophrenia during auditory word and tone working memory demonstrated by functional magnetic resonance imaging. , 1998, Archives of general psychiatry.

[28]  J. Lewald,et al.  Effects of sex and age on auditory spatial scene analysis , 2013, Hearing Research.

[29]  Yale E Cohen,et al.  Selectivity for the Spatial and Nonspatial Attributes of Auditory Stimuli in the Ventrolateral Prefrontal Cortex , 2004, The Journal of Neuroscience.

[30]  Wilkin Chau,et al.  Left thalamo-cortical network implicated in successful speech separation and identification , 2005, NeuroImage.

[31]  Jörg Lewald,et al.  Neural Correlates of Sound Localization in Complex Acoustic Environments , 2013, PloS one.

[32]  P. Garthwaite,et al.  Point and interval estimates of effect sizes for the case-controls design in neuropsychology: Rationale, methods, implementations, and proposed reporting standards , 2010, Cognitive neuropsychology.

[33]  M. Mesulam.  Principles of behavioral neurology , 1985 .

[34]  Jean-Philippe Thiran,et al.  What and Where in human audition: selective deficits following focal hemispheric lesions , 2002, Experimental Brain Research.

[35]  E. Yund,et al.  Central auditory processing III. The “cocktail party” effect and anterior temporal lobectomy , 1983, Brain and Language.

[36]  Glyn W. Humphreys,et al.  The central role of the temporo-parietal junction and the superior longitudinal fasciculus in supporting multi-item competition: Evidence from lesion-symptom mapping of extinction , 2013, Cortex.

[37]  Alan C. Evans,et al.  Auditory Attention to Space and Frequency Activates Similar Cerebral Systems , 1999, NeuroImage.

[38]  T. Griffiths,et al.  The planum temporale as a computational hub , 2002, Trends in Neurosciences.

[39]  Terence W. Picton,et al.  Effects of Attention on Neuroelectric Correlates of Auditory Stream Segregation , 2006, Journal of Cognitive Neuroscience.

[40]  A. Bregman,et al.  Primary auditory stream segregation and perception of order in rapid sequences of tones. , 1971, Journal of experimental psychology.

[41]  H. Karnath,et al.  Using human brain lesions to infer function: a relic from a past era in the fMRI age? , 2004, Nature Reviews Neuroscience.

[42]  Jörg Lewald,et al.  Male advantage in sound localization at cocktail parties , 2011, Cortex.

[43]  Chris Rorden,et al.  Age-specific CT and MRI templates for spatial normalization , 2012, NeuroImage.

[44]  Andrew J Oxenham,et al.  Human Cortical Activity during Streaming without Spectral Cues Suggests a General Neural Substrate for Auditory Stream Segregation , 2007, The Journal of Neuroscience.

[45]  Rhodri Cusack,et al.  The Intraparietal Sulcus and Perceptual Organization , 2005, Journal of Cognitive Neuroscience.

[46]  Christine Delmaire,et al.  Visualization of disconnection syndromes in humans , 2008, Cortex.

[47]  O. Bertrand,et al.  Effects of Selective Attention on the Electrophysiological Representation of Concurrent Sounds in the Human Auditory Cortex , 2007, The Journal of Neuroscience.

[48]  M. Brass,et al.  Involvement of the inferior frontal junction in cognitive control: Meta‐analyses of switching and Stroop studies , 2005, Human brain mapping.

[49]  Jörg Lewald,et al.  Processing of sound location in human cortex , 2008, The European journal of neuroscience.

[50]  Paul H Garthwaite,et al.  Testing for suspected impairments and dissociations in single-case studies in neuropsychology: evaluation of alternatives using monte carlo simulations and revised tests for dissociations. , 2005, Neuropsychology.

[51]  R. Zatorre,et al.  Spectral and temporal processing in human auditory cortex. , 2001, Cerebral cortex.

[52]  Chris Rorden,et al.  Improving Lesion-Symptom Mapping , 2007, Journal of Cognitive Neuroscience.

[53]  D. M. Green,et al.  Sound localization by human listeners. , 1991, Annual review of psychology.

[54]  G. Recanzone,et al.  Serial and parallel processing in the primate auditory cortex revisited , 2010, Behavioural Brain Research.

[55]  Leif Johannsen,et al.  How Efficient is a Simple Copying Task to Diagnose Spatial Neglect in its Chronic Phase? , 2004, Journal of clinical and experimental neuropsychology.

[56]  Jörg Lewald,et al.  When and Where of Auditory Spatial Processing in Cortex: A Novel Approach Using Electrotomography , 2011, PloS one.

[57]  Alexander Gutschalk,et al.  Transient bold activity locked to perceptual reversals of auditory streaming in human auditory cortex and inferior colliculus. , 2011, Journal of neurophysiology.

[58]  Andrew R. Dykstra,et al.  Widespread Brain Areas Engaged during a Classical Auditory Streaming Task Revealed by Intracranial EEG , 2011, Front. Hum. Neurosci..

[59]  M. Scherg,et al.  Neuromagnetic Correlates of Streaming in Human Auditory Cortex , 2005, The Journal of Neuroscience.

[60]  Jörg Lewald,et al.  Effects of natural versus artificial spatial cues on electrophysiological correlates of auditory motion , 2010, Hearing Research.

[61]  Jeffrey R Binder,et al.  Human brain regions involved in recognizing environmental sounds. , 2004, Cerebral cortex.

[62]  Alan C. Evans,et al.  Lateralization of phonetic and pitch discrimination in speech processing. , 1992, Science.

[63]  P. Bartolomeo,et al.  White matter (dis)connections and gray matter (dys)functions in visual neglect: Gaining insights into the brain networks of spatial awareness , 2008, Cortex.

[64]  Lucas Spierer,et al.  Hemispheric competence for auditory spatial representation. , 2009, Brain : a journal of neurology.

[65]  C. Weiller,et al.  Fiber pathways connecting cortical areas relevant for spatial orienting and exploration , 2014, Human brain mapping.

[66]  N. Tzourio-Mazoyer,et al.  Automated Anatomical Labeling of Activations in SPM Using a Macroscopic Anatomical Parcellation of the MNI MRI Single-Subject Brain , 2002, NeuroImage.