Differential Transduction Following Basal Ganglia Administration of Distinct Pseudotyped AAV Capsid Serotypes in Nonhuman Primates.
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[1] Nikolaus R. McFarland,et al. Comparison of transduction efficiency of recombinant AAV serotypes 1, 2, 5, and 8 in the rat nigrostriatal system , 2009, Journal of neurochemistry.
[2] B. Davidson,et al. Transduction of nonhuman primate brain with adeno-associated virus serotype 1: vector trafficking and immune response. , 2008, Human gene therapy.
[3] James M. Wilson,et al. Expanded repertoire of AAV vector serotypes mediate unique patterns of transduction in mouse brain. , 2008, Molecular therapy : the journal of the American Society of Gene Therapy.
[4] M. Souweidane,et al. Treatment of late infantile neuronal ceroid lipofuscinosis by CNS administration of a serotype 2 adeno-associated virus expressing CLN2 cDNA. , 2008, Human gene therapy.
[5] Kathleen A. Marshall,et al. Safety and efficacy of gene transfer for Leber's congenital amaurosis. , 2008, The New England journal of medicine.
[6] J. L. Eberling,et al. Results from a phase I safety trial of hAADC gene therapy for Parkinson disease , 2008, Neurology.
[7] R. Bakay,et al. Safety and tolerability of intraputaminal delivery of CERE-120 (adeno-associated virus serotype 2–neurturin) to patients with idiopathic Parkinson's disease: an open-label, phase I trial , 2008, The Lancet Neurology.
[8] D. Kirik,et al. In vivo gene delivery for development of mammalian models for Parkinson's disease , 2008, Experimental Neurology.
[9] C. Olanow,et al. Regulatable promoters and gene therapy for Parkinson's disease: Is the only thing to fear, fear itself? , 2008, Experimental Neurology.
[10] T. Flotte,et al. Recombinant adeno-associated virus-mediated global anterograde delivery of glial cell line-derived neurotrophic factor to the spinal cord: comparison of rubrospinal and corticospinal tracts in the rat. , 2008, Human gene therapy.
[11] R. Mandel,et al. Time course of transgene expression after intrastriatal pseudotyped rAAV2/1, rAAV2/2, rAAV2/5, and rAAV2/8 transduction in the rat. , 2007, Molecular therapy : the journal of the American Society of Gene Therapy.
[12] David Eidelberg,et al. Safety and tolerability of gene therapy with an adeno-associated virus (AAV) borne GAD gene for Parkinson's disease: an open label, phase I trial , 2007, The Lancet.
[13] D. Murphy,et al. Altered neocortical cell density and layer thickness in serotonin transporter knockout mice: a quantitation study. , 2007, Cerebral cortex.
[14] Zeger Debyser,et al. Comparative analysis of adeno-associated viral vector serotypes 1, 2, 5, 7, and 8 in mouse brain. , 2007, Human gene therapy.
[15] B. Hyman,et al. Adeno-associated virus vectors serotyped with AAV8 capsid are more efficient than AAV-1 or -2 serotypes for widespread gene delivery to the neonatal mouse brain , 2006, Neuroscience.
[16] R. Bakay,et al. Delivery of neurturin by AAV2 (CERE‐120)‐mediated gene transfer provides structural and functional neuroprotection and neurorestoration in MPTP‐treated monkeys , 2006, Annals of neurology.
[17] D. Shera,et al. Immune responses to AAV in a phase I study for Canavan disease , 2006, The journal of gene medicine.
[18] J. Bringas,et al. Convection-enhanced delivery of adeno-associated virus type 2 (AAV2) into the striatum and transport of AAV2 within monkey brain. , 2006, Human gene therapy.
[19] Ronald L Klein,et al. Efficient neuronal gene transfer with AAV8 leads to neurotoxic levels of tau or green fluorescent proteins. , 2006, Molecular therapy : the journal of the American Society of Gene Therapy.
[20] P. R. Hof,et al. Design-based stereology in neuroscience , 2005, Neuroscience.
[21] Brian M. Suzuki,et al. AAV2-mediated gene delivery to monkey putamen: Evaluation of an infusion device and delivery parameters , 2005, Experimental Neurology.
[22] R. Mandel,et al. Recombinant adeno-associated viral vectors in the nervous system. , 2005, Human gene therapy.
[23] James M. Wilson,et al. New recombinant serotypes of AAV vectors. , 2005, Current gene therapy.
[24] R. Mandel,et al. Systemic mannitol-induced hyperosmolality amplifies rAAV2-mediated striatal transduction to a greater extent than local co-infusion. , 2005, Molecular therapy : the journal of the American Society of Gene Therapy.
[25] T. Iwatsubo,et al. Overexpression of α‐synuclein in rat substantia nigra results in loss of dopaminergic neurons, phosphorylation of α‐synuclein and activation of caspase‐9: resemblance to pathogenetic changes in Parkinson's disease , 2004, Journal of neurochemistry.
[26] P. Reier,et al. Recombinant AAV viral vectors pseudotyped with viral capsids from serotypes 1, 2, and 5 display differential efficiency and cell tropism after delivery to different regions of the central nervous system. , 2004, Molecular therapy : the journal of the American Society of Gene Therapy.
[27] J. Feldon,et al. Transduction Profiles of Recombinant Adeno-Associated Virus Vectors Derived from Serotypes 2 and 5 in the Nigrostriatal System of Rats , 2004, Journal of Virology.
[28] R. Mandel,et al. Circulating Anti-Wild-Type Adeno-Associated Virus Type 2 (AAV2) Antibodies Inhibit Recombinant AAV2 (rAAV2)-Mediated, but Not rAAV5-Mediated, Gene Transfer in the Brain , 2004, Journal of Virology.
[29] M. Hildinger,et al. Advances in AAV-mediated gene transfer for the treatment of inherited disorders , 2004, European Journal of Human Genetics.
[30] C. Vite,et al. Adeno-associated virus vector-mediated transduction in the cat brain , 2003, Gene Therapy.
[31] Anders Björklund,et al. Modeling CNS neurodegeneration by overexpression of disease-causing proteins using viral vectors , 2003, Trends in Neurosciences.
[32] S. Leurgans,et al. Structural and functional neuroprotection in a rat model of Huntington’s disease by viral gene transfer of GDNF , 2003, Experimental Neurology.
[33] A. Björklund,et al. Nigrostriatal α-synucleinopathy induced by viral vector-mediated overexpression of human α-synuclein: A new primate model of Parkinson's disease , 2003, Proceedings of the National Academy of Sciences of the United States of America.
[34] W. Hauswirth,et al. Production and purification of serotype 1, 2, and 5 recombinant adeno-associated viral vectors. , 2002, Methods.
[35] Zeger Debyser,et al. Characterization of lentiviral vector-mediated gene transfer in adult mouse brain. , 2002, Human gene therapy.
[36] A. Björklund,et al. Parkinson-Like Neurodegeneration Induced by Targeted Overexpression of α-Synuclein in the Nigrostriatal System , 2002, The Journal of Neuroscience.
[37] Ronald L Klein,et al. Dopaminergic cell loss induced by human A30P alpha-synuclein gene transfer to the rat substantia nigra. , 2002, Human gene therapy.
[38] M. Dragunow,et al. Quantitative comparison of expression with adeno-associated virus (AAV-2) brain-specific gene cassettes , 2001, Gene Therapy.
[39] I. Martins,et al. Recombinant adeno-associated virus type 2, 4, and 5 vectors: transduction of variant cell types and regions in the mammalian central nervous system. , 2000, Proceedings of the National Academy of Sciences of the United States of America.
[40] J. Schlehofer,et al. Update on the prevalence of serum antibodies (IgG and IgM) to adeno‐associated virus (AAV) , 1999, Journal of medical virology.
[41] J. Bloch,et al. Lentiviral Gene Transfer to the Nonhuman Primate Brain , 1999, Experimental Neurology.
[42] K. Propert,et al. Immune responses to adenovirus and adeno-associated virus in humans , 1999, Gene Therapy.
[43] J. Holden,et al. Age‐related declines in nigral neuronal function correlate with motor impairments in rhesus monkeys , 1998, The Journal of comparative neurology.
[44] R. Samulski,et al. Selective and rapid uptake of adeno-associated virus type 2 in brain. , 1998, Human gene therapy.
[45] W. Hauswirth,et al. A "humanized" green fluorescent protein cDNA adapted for high-level expression in mammalian cells , 1996, Journal of virology.
[46] N. Muzyczka. Use of adeno-associated virus as a general transduction vector for mammalian cells. , 1992, Current topics in microbiology and immunology.
[47] Yamamura Ken-ichi,et al. Efficient selection for high-expression transfectants with a novel eukaryotic vector , 1991 .
[48] H. Niwa,et al. Efficient selection for high-expression transfectants with a novel eukaryotic vector. , 1991, Gene.