The present paper studies the reliability-based structural optimization of the civil engineering in the seismic zone. The objective is to minimize the sum of construction material cost and the expected failure loss under severe earthquake, which is obtained by the sum of the products of the failure probability and its failure losses for the important failure modes. The set of constraints includes the deterministic constraints, and the constraints based on structural reliability—the reliability index constraints of structural element failure for the serviceability state under minor earthquake and the failure probability of the structural system for the ultimate limit state under severe earthquake. By introducing the load roughness index, the structural system reliability computation under hazard load can be greatly simplified, which is approximately determined by its weakest failure mode. Finally, the numerical example of high rising shear RC frame is calculated.
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