The expression of fibrosis-related genes is elevated in doxorubicin-induced senescent human dermal fibroblasts, but their secretome does not trigger a paracrine fibrotic response in non-senescent cells

[1]  Jing Fang,et al.  Collagen gel contraction assays: From modelling wound healing to quantifying cellular interactions with three-dimensional extracellular matrices. , 2022, European journal of cell biology.

[2]  G. Kuchel,et al.  An inducible p21-Cre mouse model to monitor and manipulate p21-highly-expressing senescent cells in vivo , 2021, Nature Aging.

[3]  N. Rosenthal,et al.  Fibroblasts: Origins, definitions, and functions in health and disease , 2021, Cell.

[4]  M. Schuliga,et al.  Regulation of Cellular Senescence Is Independent from Profibrotic Fibroblast-Deposited ECM , 2021, Cells.

[5]  M. Schosserer,et al.  The role of lipid-based signalling in wound healing and senescence , 2021, Mechanisms of Ageing and Development.

[6]  P. Maity,et al.  Connective Tissue and Fibroblast Senescence in Skin Aging. , 2021, The Journal of investigative dermatology.

[7]  Y. Furukawa,et al.  Senolysis by glutaminolysis inhibition ameliorates various age-associated disorders , 2021, Science.

[8]  Caizhen Li,et al.  Senolytic therapy ameliorates renal fibrosis postacute kidney injury by alleviating renal senescence , 2020, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[9]  M. Mildner,et al.  Epilipidomics of senescent dermal fibroblasts identify lysophosphatidylcholines as pleiotropic SASP factors. , 2020, The Journal of investigative dermatology.

[10]  F. Bard,et al.  Red-COLA1: a human fibroblast reporter cell line for type I collagen transcription , 2020, Scientific Reports.

[11]  J. Björkegren,et al.  Publisher Correction: Single-cell analysis uncovers fibroblast heterogeneity and criteria for fibroblast and mural cell identification and discrimination , 2020, Nature Communications.

[12]  J. Björkegren,et al.  Single-cell analysis uncovers fibroblast heterogeneity and criteria for fibroblast and mural cell identification and discrimination , 2020, Nature Communications.

[13]  M. Longaker,et al.  Understanding the impact of fibroblast heterogeneity on skin fibrosis , 2020, Disease Models & Mechanisms.

[14]  M. Fear,et al.  The Role of IL-6 in Skin Fibrosis and Cutaneous Wound Healing , 2020, Biomedicines.

[15]  Md Jamal Uddin,et al.  PGC‐1α, a potential therapeutic target against kidney aging , 2019, Aging cell.

[16]  S. Amano,et al.  Senescent dermal fibroblasts negatively influence fibroblast extracellular matrix‐related gene expression partly via secretion of complement factor D , 2019, BioFactors.

[17]  F. Gruber,et al.  Small extracellular vesicles and their miRNA cargo are anti-apoptotic members of the senescence-associated secretory phenotype , 2018, Aging.

[18]  F. Gruber,et al.  Blocking negative effects of senescence in human skin fibroblasts with a plant extract , 2018, npj Aging and Mechanisms of Disease.

[19]  J. Gil,et al.  Mechanisms and functions of cellular senescence. , 2018, The Journal of clinical investigation.

[20]  L. Lau,et al.  Resolution of organ fibrosis , 2018, Journal of Clinical Investigation.

[21]  R. Goldschmeding,et al.  Cellular senescence in the aging and diseased kidney , 2017, Journal of Cell Communication and Signaling.

[22]  Wiggert A. van Cappellen,et al.  Targeted Apoptosis of Senescent Cells Restores Tissue Homeostasis in Response to Chemotoxicity and Aging , 2017, Cell.

[23]  A. Oberg,et al.  Cellular senescence mediates fibrotic pulmonary disease , 2017, Nature Communications.

[24]  B. Kennedy,et al.  Cellular Senescence Promotes Adverse Effects of Chemotherapy and Cancer Relapse. , 2017, Cancer discovery.

[25]  P. Slagboom,et al.  P16INK4a Positive Cells in Human Skin Are Indicative of Local Elastic Fiber Morphology, Facial Wrinkling, and Perceived Age. , 2016, The journals of gerontology. Series A, Biological sciences and medical sciences.

[26]  A. Phillips,et al.  17β‐estradiol ameliorates age‐associated loss of fibroblast function by attenuating IFN‐γ/STAT1‐dependent miR‐7 upregulation , 2016, Aging cell.

[27]  Min Zhang,et al.  Identification of a novel TGF-β-miR-122-fibronectin 1/serum response factor signaling cascade and its implication in hepatic fibrogenesis , 2015, Oncotarget.

[28]  J. Hoeijmakers,et al.  An essential role for senescent cells in optimal wound healing through secretion of PDGF-AA. , 2014, Developmental cell.

[29]  J. Campisi Aging, cellular senescence, and cancer. , 2013, Annual review of physiology.

[30]  J. Campisi,et al.  Lamin B1 loss is a senescence-associated biomarker , 2012, Molecular biology of the cell.

[31]  B. Hinz,et al.  Recent developments in myofibroblast biology: paradigms for connective tissue remodeling. , 2012, The American journal of pathology.

[32]  Hui Zhu Cell Proliferation Assay by Flow Cytometry (BrdU and PI Staining) , 2012 .

[33]  M. Blagosklonny Cell cycle arrest is not senescence , 2011, Aging.

[34]  J. Campisi,et al.  The senescence-associated secretory phenotype: the dark side of tumor suppression. , 2010, Annual review of pathology.

[35]  P. Adams Healing and hurting: molecular mechanisms, functions, and pathologies of cellular senescence. , 2009, Molecular cell.

[36]  S. Lowe,et al.  Senescence of Activated Stellate Cells Limits Liver Fibrosis , 2008, Cell.

[37]  Michael T Longaker,et al.  The fibroblast‐populated collagen matrix as a model of wound healing: a review of the evidence , 2004, Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society.

[38]  C Roskelley,et al.  A biomarker that identifies senescent human cells in culture and in aging skin in vivo. , 1995, Proceedings of the National Academy of Sciences of the United States of America.