Achievement of live birth after overcoming two gynecological malignancies treated with radical trachelectomy and medroxyprogesterone acetate therapy

Cervical cancer is a human papilloma virus‐related disease, whereas endometrial cancer and atypical endometrial hyperplasia (AEH) are hormone‐related diseases, so co‐occurrence of the two is possible. However, scientific studies about such cases are rare. We encountered a case of cervical adenocarcinoma and AEH in a 33‐year‐old nulliparous woman. Two fertility‐sparing treatments were performed, a radical trachelectomy for the cervical cancer and high‐dose medroxyprogesterone acetate treatment for the AEH. After remission of the diseases, the patient became pregnant by in vitro fertilization and delivered a baby at 36 weeks' gestation by cesarean section. Although the patient had two uterine malignancies, proper evaluation of the diseases, consultation with the patient and her husband, and appropriate management led to fertility preservation, and live birth was achieved.

[1]  S. Ghaem-Maghami,et al.  Fertility treatment and cancers-the eternal conundrum: a systematic review and meta-analysis. , 2021, Human reproduction.

[2]  C. Venetis.  Endometrial injury before IVF: light at the end of the tunnel or false hope? , 2020, Human reproduction.

[3]  M. Leitao,et al.  Radical Trachelectomy for the Treatment of Early-Stage Cervical Cancer: A Systematic Review. , 2020, Obstetrics and gynecology.

[4]  A. Ciavattini,et al.  Atypical Endometrial Hyperplasia and Unexpected Cancers at Final Histology: A Study on Endometrial Sampling Methods and Risk Factors , 2020, Diagnostics.

[5]  J. Perz,et al.  Maternal health service utilisation of adolescent women in sub-Saharan Africa: a systematic scoping review , 2019, BMC Pregnancy and Childbirth.

[6]  H. Sasano,et al.  Multiple primary cancers associated with endometrial and ovarian cancers: An analysis based upon the Japan Autopsy Annual Database from 2002 to 2010 , 2019, The journal of obstetrics and gynaecology research.

[7]  R. Zimmermann,et al.  Maternal and neonatal outcome of reverse breech extraction of an impacted fetal head during caesarean section in advanced stage of labour: a retrospective cohort study , 2019, BMC Pregnancy and Childbirth.

[8]  H. Kajiyama,et al.  Efficacy of medroxyprogesterone acetate treatment and retreatment for atypical endometrial hyperplasia and endometrial cancer , 2018, The journal of obstetrics and gynaecology research.

[9]  J. Blohmer,et al.  Follow-up after radical vaginal trachelectomy (RVT): patients’ problems and physicians’ difficulties , 2017, Archives of Gynecology and Obstetrics.

[10]  Xiaojun Chen,et al.  Menstrual pattern after abdominal radical trachelectomy , 2017, Oncotarget.

[11]  H. Kajiyama,et al.  Oncologic and obstetric outcomes of early stage cervical cancer with abdominal radical trachelectomy: Single‐institution experience , 2016, The journal of obstetrics and gynaecology research.

[12]  Hiroshi Nishimoto,et al.  Cancer incidence and incidence rates in Japan in 2008: a study of 25 population-based cancer registries for the Monitoring of Cancer Incidence in Japan (MCIJ) project. , 2012, Japanese journal of clinical oncology.

[13]  K. Carson,et al.  Oncologic and reproductive outcomes with progestin therapy in women with endometrial hyperplasia and grade 1 adenocarcinoma: a systematic review. , 2012, Gynecologic oncology.

[14]  C. Purandare,et al.  Indian Contribution to Obstetrics and Gynecology , 2012, The Journal of Obstetrics and Gynecology of India.

[15]  W. Ajiki,et al.  Cancer incidence and incidence rates in Japan in 2006: based on data from 15 population-based cancer registries in the monitoring of cancer incidence in Japan (MCIJ) project. , 2012, Japanese journal of clinical oncology.

[16]  Ie-Ming Shih,et al.  The Origin and Pathogenesis of Epithelial Ovarian Cancer: A Proposed Unifying Theory , 2010, The American journal of surgical pathology.

[17]  Eileen M. Burd,et al.  Human Papillomavirus and Cervical Cancer , 1988, The Lancet.