Complex I inhibitor of oxidative phosphorylation in advanced solid tumors and acute myeloid leukemia: phase I trials

[1]  Hyo Song Kim,et al.  First-in-human study of IM156, a novel potent biguanide oxidative phosphorylation (OXPHOS) inhibitor, in patients with advanced solid tumors , 2022, Investigational New Drugs.

[2]  A. Kavelaars,et al.  An HDAC6 inhibitor reverses chemotherapy-induced mechanical hypersensitivity via an IL-10 and macrophage dependent pathway , 2021, Brain, Behavior, and Immunity.

[3]  C. Dang,et al.  Targeting cancer metabolism in the era of precision oncology , 2021, Nature reviews. Drug discovery.

[4]  K. Ikeo,et al.  Exogenous mitochondrial transfer and endogenous mitochondrial fission facilitate AML resistance to OxPhos inhibition , 2021, Blood advances.

[5]  J. Hirst,et al.  Cork-in-bottle mechanism of inhibitor binding to mammalian complex I , 2021, Science Advances.

[6]  A. Mansfield,et al.  First-in-human evaluation of the novel mitochondrial complex I inhibitor ASP4132 for treatment of cancer , 2021, Investigational New Drugs.

[7]  F. Jourdan,et al.  Mitochondrial metabolism supports resistance to IDH mutant inhibitors in acute myeloid leukemia , 2021, The Journal of experimental medicine.

[8]  Z. J. Holmes,et al.  The low molecular weight protein tyrosine phosphatase promotes adipogenesis and subcutaneous adipocyte hypertrophy , 2021, Journal of cellular physiology.

[9]  N. Neamati,et al.  Why All the Fuss about Oxidative Phosphorylation (OXPHOS)? , 2020, Journal of medicinal chemistry.

[10]  Hyo Song Kim,et al.  Phase I study of IM156, a novel potent biguanide oxidative phosphorylation (OXPHOS) inhibitor, in patients with advanced solid tumors. , 2020 .

[11]  R. Dantzer,et al.  Interleukin-10 resolves pain hypersensitivity induced by cisplatin by reversing sensory neuron hyperexcitability. , 2020, Pain.

[12]  Bo Peng,et al.  The fibroblast-derived protein PI16 controls neuropathic pain , 2020, Proceedings of the National Academy of Sciences.

[13]  Keita Ohnuki,et al.  Development of a potent and orally active activator of adenosine monophosphate-activated protein kinase (AMPK), ASP4132, as a clinical candidate for the treatment of human cancer. , 2020, Bioorganic & medicinal chemistry.

[14]  P. Matthias,et al.  Cell-specific role of HDAC6 in chemotherapy-induced mechanical allodynia and loss of intraepidermal nerve fibers. , 2019, Pain.

[15]  J. Kirk,et al.  Systematic evaluation of RNA-Seq preparation protocol performance , 2019, BMC Genomics.

[16]  Mike Tyers,et al.  Mubritinib Targets the Electron Transport Chain Complex I and Reveals the Landscape of OXPHOS Dependency in Acute Myeloid Leukemia. , 2019, Cancer cell.

[17]  D. Kazis,et al.  Neurological adverse events post allogeneic hematopoietic cell transplantation: major determinants of morbidity and mortality , 2019, Journal of Neurology.

[18]  S. Kiryu-Seo,et al.  Mitochondrial behavior during axon regeneration/degeneration in vivo , 2019, Neuroscience Research.

[19]  P. Siegel,et al.  Metabolic Profiles Associated With Metformin Efficacy in Cancer , 2018, Front. Endocrinol..

[20]  P. A. Futreal,et al.  Mutations in the SWI/SNF complex induce a targetable dependence on oxidative phosphorylation in lung cancer , 2018, Nature Medicine.

[21]  M. Protopopova,et al.  An inhibitor of oxidative phosphorylation exploits cancer vulnerability , 2018, Nature Medicine.

[22]  P. Dougherty,et al.  Beyond symptomatic relief for chemotherapy‐induced peripheral neuropathy: Targeting the source , 2018, Cancer.

[23]  K. Ballen,et al.  Neurologic complications after allogeneic hematopoietic stem cell transplantation: risk factors and impact , 2018, Bone Marrow Transplantation.

[24]  Eyal Gottlieb,et al.  Targeting mitochondrial oxidative phosphorylation eradicates therapy-resistant chronic myeloid leukemic stem cells , 2017, Nature Medicine.

[25]  Irina Vetter,et al.  Methods Used to Evaluate Pain Behaviors in Rodents , 2017, Front. Mol. Neurosci..

[26]  Achinto Saha,et al.  Combinatorial treatment with natural compounds in prostate cancer inhibits prostate tumor growth and leads to key modulations of cancer cell metabolism , 2017, npj Precision Oncology.

[27]  Jesse D. Gelles,et al.  Disruption of mitochondrial electron transport chain function potentiates the pro-apoptotic effects of MAPK inhibition , 2017, The Journal of Biological Chemistry.

[28]  A. Kavelaars,et al.  Inhibition of Mitochondrial p53 Accumulation by PFT-μ Prevents Cisplatin-Induced Peripheral Neuropathy , 2017, Front. Mol. Neurosci..

[29]  Geet Duggal,et al.  Salmon: fast and bias-aware quantification of transcript expression using dual-phase inference , 2017, Nature Methods.

[30]  Ralph Mazitschek,et al.  HDAC6 inhibition effectively reverses chemotherapy-induced peripheral neuropathy , 2017, Brain, Behavior, and Immunity.

[31]  D. Kirkpatrick,et al.  Clinically Evaluated Cancer Drugs Inhibiting Redox Signaling. , 2017, Antioxidants & redox signaling.

[32]  Bob Löwenberg,et al.  Diagnosis and management of AML in adults: 2017 ELN recommendations from an international expert panel. , 2017, Blood.

[33]  K. Suk,et al.  Metabolic reprogramming by the pyruvate dehydrogenase kinase–lactic acid axis: Linking metabolism and diverse neuropathophysiologies , 2016, Neuroscience & Biobehavioral Reviews.

[34]  F. Scaglia,et al.  Mitochondrial Cardiomyopathies , 2016, Front. Cardiovasc. Med..

[35]  A. Kavelaars,et al.  Prevention of chemotherapy-induced peripheral neuropathy by the small-molecule inhibitor pifithrin-&mgr; , 2015, Pain.

[36]  Andrea Glasauer,et al.  Targeting mitochondrial complex I using BAY 87-2243 reduces melanoma tumor growth , 2015, Cancer & metabolism.

[37]  T. Brannagan,et al.  Neuromuscular complications of hematopoietic stem cell transplantation , 2015, Muscle & nerve.

[38]  R. Kolde,et al.  GOsummaries: an R Package for Visual Functional Annotation of Experimental Data , 2015, F1000Research.

[39]  M. V. Heiden,et al.  Supporting Aspartate Biosynthesis Is an Essential Function of Respiration in Proliferating Cells , 2015, Cell.

[40]  Bin Wang,et al.  Seq2pathway: an R/Bioconductor package for pathway analysis of next-generation sequencing data , 2015, Bioinform..

[41]  J. Ehinger,et al.  Metformin induces lactate production in peripheral blood mononuclear cells and platelets through specific mitochondrial complex I inhibition , 2015, Acta physiologica.

[42]  E. H. Howlett,et al.  PCR based determination of mitochondrial DNA copy number in multiple species. , 2015, Methods in molecular biology.

[43]  J. Finsterer,et al.  Cardiac manifestations of primary mitochondrial disorders. , 2014, International journal of cardiology.

[44]  M. Pollak,et al.  Effects of metformin and other biguanides on oxidative phosphorylation in mitochondria , 2014, The Biochemical journal.

[45]  C. Cleeland,et al.  The Anti-Diabetic Drug Metformin Protects against Chemotherapy-Induced Peripheral Neuropathy in a Mouse Model , 2014, PloS one.

[46]  G. Bennett,et al.  Mitotoxicity in distal symmetrical sensory peripheral neuropathies , 2014, Nature Reviews Neurology.

[47]  S. Koeppen,et al.  Neuromuscular complications after hematopoietic stem cell transplantation , 2014, Supportive Care in Cancer.

[48]  J. Hirst.  Mitochondrial complex I. , 2013, Annual review of biochemistry.

[49]  John M. Ashton,et al.  BCL-2 inhibition targets oxidative phosphorylation and selectively eradicates quiescent human leukemia stem cells. , 2013, Cell stem cell.

[50]  J. Smeitink,et al.  OXPHOS mutations and neurodegeneration , 2012, The EMBO journal.

[51]  G. Bennett,et al.  Mitotoxicity and bortezomib-induced chronic painful peripheral neuropathy , 2012, Experimental Neurology.

[52]  G. Bennett,et al.  Effects of mitochondrial poisons on the neuropathic pain produced by the chemotherapeutic agents, paclitaxel and oxaliplatin , 2012, PAIN.

[53]  T. Seki,et al.  Comparison of potential risks of lactic acidosis induction by biguanides in rats. , 2010, Regulatory toxicology and pharmacology : RTP.

[54]  A. Schapira.  Complex I: Inhibitors, inhibition and neurodegeneration , 2010, Experimental Neurology.

[55]  A. D. Van den Abbeele,et al.  Revised RECIST guideline version 1.1: What oncologists want to know and what radiologists need to know. , 2010, AJR. American journal of roentgenology.

[56]  K. Kaluarachchi,et al.  Pharmacologic inhibition of fatty acid oxidation sensitizes human leukemia cells to apoptosis induction. , 2010, The Journal of clinical investigation.

[57]  M. Robinson,et al.  A scaling normalization method for differential expression analysis of RNA-seq data , 2010, Genome Biology.

[58]  L. Marroquin,et al.  Biguanide-induced mitochondrial dysfunction yields increased lactate production and cytotoxicity of aerobically-poised HepG2 cells and human hepatocytes in vitro. , 2008, Toxicology and applied pharmacology.

[59]  A. Cáceres,et al.  Rotenone-induced toxicity is mediated by Rho-GTPases in hippocampal neurons. , 2008, Toxicological sciences : an official journal of the Society of Toxicology.

[60]  Robert J. Gillies,et al.  Causes and Consequences of Increased Glucose Metabolism of Cancers , 2008, Journal of Nuclear Medicine.

[61]  Peer Bork,et al.  KEGG Atlas mapping for global analysis of metabolic pathways , 2008, Nucleic Acids Res..

[62]  J. Lipton,et al.  Central nervous system complications after allogeneic hematopoietic stem cell transplantation: incidence, manifestations, and clinical significance. , 2007, Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation.

[63]  Ying Zhang,et al.  HMDB: the Human Metabolome Database , 2007, Nucleic Acids Res..

[64]  Gary J. Bennett,et al.  Studies of peripheral sensory nerves in paclitaxel-induced painful peripheral neuropathy: Evidence for mitochondrial dysfunction , 2006, Pain.

[65]  Todd B. Sherer,et al.  Chronic systemic pesticide exposure reproduces features of Parkinson's disease , 2000, Nature Neuroscience.

[66]  K. Mills,et al.  Amplification of mitochondrial DNA in acute myeloid leukaemia , 1994, British journal of haematology.

[67]  Y. Benjamini,et al.  Controlling the false discovery rate: a practical and powerful approach to multiple testing , 1995 .

[68]  T. Yaksh,et al.  Quantitative assessment of tactile allodynia in the rat paw , 1994, Journal of Neuroscience Methods.