A novel cell-based sensor detecting the activity of individual basic proprotein convertases
暂无分享,去创建一个
N. Seidah | D. Constam | A. Roulin | S. Kunz | Kornelia Hardes | T. Steinmetzer | A. Pasquato | C. Fedeli | Karin Löw | Nabil G. Seidah
[1] Kornelia Hardes,et al. New substrate analogue furin inhibitors derived from 4-amidinobenzylamide. , 2011, Bioorganic & medicinal chemistry letters.
[2] M. Vey,et al. Influenza virus hemagglutinin with multibasic cleavage site is activated by furin, a subtilisin‐like endoprotease. , 1992, The EMBO journal.
[3] T. Willnow,et al. VPS10P-domain receptors — regulators of neuronal viability and function , 2008, Nature Reviews Neuroscience.
[4] D. Constam,et al. Imaging proprotein convertase activities and their regulation in the implanting mouse blastocyst , 2010, The Journal of cell biology.
[5] A. Amon,et al. Emerging roles for centromeres in meiosis I chromosome segregation , 2008, Nature Reviews Genetics.
[6] N. Seidah,et al. Proprotein and prohormone convertases: a family of subtilases generating diverse bioactive polypeptides 1 Published on the World Wide Web on 17 August 1999. 1 , 1999, Brain Research.
[7] I. Lindberg,et al. Optimization of Substrate‐Analogue Furin Inhibitors , 2017, ChemMedChem.
[8] M. Than,et al. Structural Studies Revealed Active Site Distortions of Human Furin by a Small Molecule Inhibitor. , 2017, ACS chemical biology.
[9] I. Lindberg,et al. Highly Potent Inhibitors of Proprotein Convertase Furin as Potential Drugs for Treatment of Infectious Diseases* , 2012, The Journal of Biological Chemistry.
[10] N. Seidah,et al. Proprotein Convertase Activity Contributes to the Processing of the Alzheimer's β‐Amyloid Precursor Protein in Human Cells: Evidence for a Role of the Prohormone Convertase PC7 in the Constitutive ‐Secretase Pathway , 1999, Journal of neurochemistry.
[11] S. Kunz,et al. A Molecular Sensor To Characterize Arenavirus Envelope Glycoprotein Cleavage by Subtilisin Kexin Isozyme 1/Site 1 Protease , 2015, Journal of Virology.
[12] G. Thomas,et al. Furin at the cutting edge: From protein traffic to embryogenesis and disease , 2002, Nature Reviews Molecular Cell Biology.
[13] P. Jaaks,et al. The proprotein convertase furin in tumour progression , 2017, International journal of cancer.
[14] S. Brunak,et al. A Systematic Study of Site-specific GalNAc-type O-Glycosylation Modulating Proprotein Convertase Processing* , 2011, The Journal of Biological Chemistry.
[15] N. Seidah. The proprotein convertases, 20 years later. , 2011, Methods in molecular biology.
[16] M. Mumby,et al. Regulation of Endosome Sorting by a Specific PP2A Isoform , 1998, The Journal of cell biology.
[17] N. Seidah,et al. Mechanism of Folding and Activation of Subtilisin Kexin Isozyme-1 (SKI-1)/Site-1 Protease (S1P)* , 2015, The Journal of Biological Chemistry.
[18] S. Opal,et al. Proprotein convertases in health and disease. , 2011, The New England journal of medicine.
[19] K. Nakayama,et al. Localization of Furin to the trans-Golgi Network and Recycling from the Cell Surface Involves Ser and Tyr Residues within the Cytoplasmic Domain (*) , 1995, The Journal of Biological Chemistry.
[20] P. Gleeson,et al. Rab9-dependent retrograde transport and endosomal sorting of the endopeptidase furin , 2011, Journal of Cell Science.
[21] G. Thomas,et al. The Ordered and Compartment-specific Autoproteolytic Removal of the Furin Intramolecular Chaperone Is Required for Enzyme Activation* , 2002, The Journal of Biological Chemistry.
[22] D. Constam,et al. PC7 and the related proteases Furin and Pace4 regulate E-cadherin function during blastocyst formation , 2015, The Journal of cell biology.
[23] F. Maxfield,et al. Chimeric Forms of Furin and Tgn38 Are Transported from the Plasma Membrane to the Trans-Golgi Network via Distinct Endosomal Pathways , 1999, The Journal of cell biology.
[24] I. Lindberg,et al. Identification of Inhibitors of Prohormone Convertases 1 and 2 Using a Peptide Combinatorial Library* , 1998, The Journal of Biological Chemistry.
[25] A. Beaudet,et al. Internalization and trafficking of neurotensin via NTS3 receptors in HT29 cells. , 2004, The international journal of biochemistry & cell biology.
[26] L. Wan,et al. PACS-1 Defines a Novel Gene Family of Cytosolic Sorting Proteins Required for trans-Golgi Network Localization , 1998, Cell.
[27] R. Day,et al. Cutting back on pro-protein convertases: the latest approaches to pharmacological inhibition , 2005, Trends in Pharmacological Sciences.
[28] B. Ross,et al. Identification of inhibitors using a cell-based assay for monitoring Golgi-resident protease activity. , 2007, Analytical biochemistry.
[29] I. Lindberg,et al. Potent inhibitors of furin and furin-like proprotein convertases containing decarboxylated P1 arginine mimetics. , 2010, Journal of medicinal chemistry.
[30] A. Linstedt,et al. A Sensor of Protein O‐Glycosylation Based on Sequential Processing in the Golgi Apparatus , 2013, Traffic.
[31] D. Constam,et al. Compartment-Specific Biosensors Reveal a Complementary Subcellular Distribution of Bioactive Furin and PC7. , 2018, Cell reports.
[32] D. Constam,et al. The microenvironment patterns the pluripotent mouse epiblast through paracrine Furin and Pace4 proteolytic activities. , 2011, Genes & development.
[33] Annik Prat,et al. The biology and therapeutic targeting of the proprotein convertases , 2012, Nature Reviews Drug Discovery.
[34] I. Lindberg,et al. Polyarginines Are Potent Furin Inhibitors* , 2000, The Journal of Biological Chemistry.
[35] R. Huber,et al. Structure of the unliganded form of the proprotein convertase furin suggests activation by a substrate-induced mechanism , 2016, Proceedings of the National Academy of Sciences.
[36] R. Day,et al. Therapeutic uses of furin and its inhibitors: a patent review , 2015, Expert opinion on therapeutic patents.
[37] B. Grant,et al. Intracellular trafficking. , 2006, WormBook : the online review of C. elegans biology.
[38] Huiyu Jiang,et al. Inhibition of furin results in increased growth, invasiveness and cytokine production of synoviocytes from patients with rheumatoid arthritis. , 2017, Joint, bone, spine : revue du rhumatisme.
[39] Thomas D. Y. Chung,et al. A Simple Statistical Parameter for Use in Evaluation and Validation of High Throughput Screening Assays , 1999, Journal of biomolecular screening.
[40] A. Prat,et al. The proprotein convertases are potential targets in the treatment of dyslipidemia , 2007, Journal of Molecular Medicine.
[41] Y. Loh,et al. 60 YEARS OF POMC: Biosynthesis, trafficking, and secretion of pro-opiomelanocortin-derived peptides. , 2016, Journal of molecular endocrinology.
[42] A. Prat,et al. Precursor convertases in the secretory pathway, cytosol and extracellular milieu. , 2002, Essays in biochemistry.
[43] H. Klenk,et al. Inhibition of furin-mediated cleavage activation of HIV-1 glycoprotein gpl60 , 1992, Nature.
[44] T. Komiyama,et al. Engineered eglin c variants inhibit yeast and human proprotein processing proteases, Kex2 and furin. , 2000, Biochemistry.
[45] H. Klenk,et al. Endoproteolytic Cleavage of Its Propeptide Is a Prerequisite for Efficient Transport of Furin Out of the Endoplasmic Reticulum (*) , 1995, The Journal of Biological Chemistry.
[46] I. Lindberg,et al. Novel Furin Inhibitors with Potent Anti‐infectious Activity , 2015, ChemMedChem.
[47] D. Teplow,et al. A Furin-like Convertase Mediates Propeptide Cleavage of BACE, the Alzheimer's β-Secretase* , 2000, The Journal of Biological Chemistry.
[48] N. Seidah,et al. Zymogen Activation and Subcellular Activity of Subtilisin Kexin Isozyme 1/Site 1 Protease* , 2014, The Journal of Biological Chemistry.
[49] H. Brandstetter,et al. X-ray Structures of Human Furin in Complex with Competitive Inhibitors , 2014, ACS chemical biology.
[50] G. Thomas,et al. Intracellular trafficking and activation of the furin proprotein convertase: localization to the TGN and recycling from the cell surface. , 1994, The EMBO journal.
[51] S. Millis,et al. Synthetic small molecule furin inhibitors derived from 2,5-dideoxystreptamine , 2006, Proceedings of the National Academy of Sciences.
[52] E. Fleck,et al. Proprotein convertases furin and PC5: targeting atherosclerosis and restenosis at multiple levels , 2005, Journal of Molecular Medicine.
[53] N. Seidah,et al. Mammalian subtilisin/kexin isozyme SKI-1: A widely expressed proprotein convertase with a unique cleavage specificity and cellular localization. , 1999, Proceedings of the National Academy of Sciences of the United States of America.
[54] A. Prat,et al. The activation and physiological functions of the proprotein convertases. , 2008, The international journal of biochemistry & cell biology.