Environmental pollution caused by conventional petro-diesel initiates at time of crude oil extraction and continues until its consumption. The resulting emission of poisonous gases during the combustion of petroleum-based fuel has worsened the greenhouse effect and global warming. Moreover, exhaustion of finite fossil fuels due to extensive exploitation has made the search for renewable resources indispensable. In light of this, biodiesel is a best possible substitute for the regular petro-diesel as it is eco-friendly, renewable, and economically viable. For effective biodiesel synthesis, the selection of potential feedstock and choice of efficient catalyst is the most important criteria. The main objective of this bibliographical review is to highlight vital role of different catalytic systems acting on variable feedstock and diverse methods for catalysis of biodiesel synthesis reactions. This paper further explores the effects of optimized reaction parameters, modification in chemical compositions, reaction operating parameters, mechanism and methodologies for catalysts preparation, stability enhancement, recovery, and reusability with the maximum optimum activity of catalysts. In future, the development of well-planned incentive structures is necessary for systematic progression of biodiesel process. Besides this, the selection of accessible and amended approaches for synthesis and utilization of specific potential catalysts will ensure the sustainability of eco-green biodiesel.