MAPK signal specificity: the right place at the right time.

[1]  Todd R. Golub,et al.  BRAF mutation predicts sensitivity to MEK inhibition , 2006, Nature.

[2]  Yukichi Tanaka,et al.  Germline mutations in HRAS proto-oncogene cause Costello syndrome , 2005, Nature Genetics.

[3]  T. Meyer,et al.  Reversible intracellular translocation of KRas but not HRas in hippocampal neurons regulated by Ca2+/calmodulin , 2005, The Journal of cell biology.

[4]  J. Blenis,et al.  Spatially Separate Docking Sites on ERK2 Regulate Distinct Signaling Events In Vivo , 2005, Current Biology.

[5]  Jeffrey P. MacKeigan,et al.  Graded Mitogen-Activated Protein Kinase Activity Precedes Switch-Like c-Fos Induction in Mammalian Cells , 2005, Molecular and Cellular Biology.

[6]  Shinya Kuroda,et al.  Prediction and validation of the distinct dynamics of transient and sustained ERK activation , 2005, Nature Cell Biology.

[7]  Herbert Waldmann,et al.  An Acylation Cycle Regulates Localization and Activity of Palmitoylated Ras Isoforms , 2005, Science.

[8]  K. Simons,et al.  Ras on the Roundabout , 2005, Science.

[9]  Jeffrey L. Wrana,et al.  Clathrin- and non-clathrin-mediated endocytic regulation of cell signalling , 2005, Nature Reviews Molecular Cell Biology.

[10]  M. White,et al.  Stimulus-Coupled Spatial Restriction of Extracellular Signal-Regulated Kinase 1/2 Activity Contributes to the Specificity of Signal-Response Pathways , 2004, Molecular and Cellular Biology.

[11]  E. Nishida,et al.  Sef is a spatial regulator for Ras/MAP kinase signaling. , 2004, Developmental cell.

[12]  D. Bar-Sagi,et al.  Modulation of signalling by Sprouty: a developing story , 2004, Nature Reviews Molecular Cell Biology.

[13]  J. Blenis,et al.  ERK and p38 MAPK-Activated Protein Kinases: a Family of Protein Kinases with Diverse Biological Functions , 2004, Microbiology and Molecular Biology Reviews.

[14]  E. Goldsmith,et al.  Docking motif interactions in MAP kinases revealed by hydrogen exchange mass spectrometry. , 2004, Molecular cell.

[15]  E. Asante-Appiah,et al.  Protein Tyrosine Phosphatase-1B Dephosphorylation of the Insulin Receptor Occurs in a Perinuclear Endosome Compartment in Human Embryonic Kidney 293 Cells* , 2004, Journal of Biological Chemistry.

[16]  A. Musti,et al.  Differential Phosphorylation of c-Jun and JunD in Response to the Epidermal Growth Factor Is Determined by the Structure of MAPK Targeting Sequences* , 2004, Journal of Biological Chemistry.

[17]  Jeffrey P. MacKeigan,et al.  A Network of Immediate Early Gene Products Propagates Subtle Differences in Mitogen-Activated Protein Kinase Signal Amplitude and Duration , 2004, Molecular and Cellular Biology.

[18]  Peter J. Cullen,et al.  Phospholipase Cγ activates Ras on the Golgi apparatus by means of RasGRP1 , 2003, Nature.

[19]  J. Blenis,et al.  Phosphorylation of p90 Ribosomal S6 Kinase (RSK) Regulates Extracellular Signal-Regulated Kinase Docking and RSK Activity , 2003, Molecular and Cellular Biology.

[20]  Morag Park,et al.  Escape from Cbl-mediated downregulation: a recurrent theme for oncogenic deregulation of receptor tyrosine kinases. , 2003, Cancer cell.

[21]  E. Nishida,et al.  Molecular recognitions in the MAP kinase cascades. , 2003, Cellular signalling.

[22]  T. Bivona,et al.  Ras pathway signaling on endomembranes. , 2003, Current opinion in cell biology.

[23]  H Steven Wiley,et al.  Trafficking of the ErbB receptors and its influence on signaling. , 2003, Experimental cell research.

[24]  T. Issad,et al.  Dynamics of the interaction between the insulin receptor and protein tyrosine-phosphatase 1B in living cells. , 2003, EMBO reports.

[25]  D. Teis,et al.  Localization of the MP1-MAPK scaffold complex to endosomes is mediated by p14 and required for signal transduction. , 2002, Developmental cell.

[26]  E. Nishida,et al.  Sprouty1 and Sprouty2 provide a control mechanism for the Ras/MAPK signalling pathway , 2002, Nature Cell Biology.

[27]  Rey-Huei Chen,et al.  Molecular interpretation of ERK signal duration by immediate early gene products , 2002, Nature Cell Biology.

[28]  J. B. Sajous,et al.  Ras signalling on the endoplasmic reticulum and the Golgi , 2002, Nature Cell Biology.

[29]  M. Cobb,et al.  Identification of Novel Point Mutations in ERK2 That Selectively Disrupt Binding to MEK1* , 2002, The Journal of Biological Chemistry.

[30]  Peter J Verveer,et al.  Imaging Sites of Receptor Dephosphorylation by PTP1B on the Surface of the Endoplasmic Reticulum , 2002, Science.

[31]  M. Fürthauer,et al.  Sef is a feedback-induced antagonist of Ras/MAPK-mediated FGF signalling , 2002, Nature Cell Biology.

[32]  J. Blenis,et al.  Characterization of Regulatory Events Associated with Membrane Targeting of p90 Ribosomal S6 Kinase 1 , 2001, Molecular and Cellular Biology.

[33]  M. Camps,et al.  The nucleus, a site for signal termination by sequestration and inactivation of p42/p44 MAP kinases. , 2001, Journal of cell science.

[34]  Y. Yarden The EGFR family and its ligands in human cancer. signalling mechanisms and therapeutic opportunities. , 2001, European journal of cancer.

[35]  K Kornfeld,et al.  Docking Sites on Substrate Proteins Direct Extracellular Signal-regulated Kinase to Phosphorylate Specific Residues* , 2001, The Journal of Biological Chemistry.

[36]  B. Neel,et al.  Combinatorial control of the specificity of protein tyrosine phosphatases. , 2001, Current opinion in cell biology.

[37]  M. Malumbres,et al.  Targeted Genomic Disruption of H-ras and N-ras, Individually or in Combination, Reveals the Dispensability of Both Loci for Mouse Growth and Development , 2001, Molecular and Cellular Biology.

[38]  A. Pfeifer,et al.  A Novel 14-Kilodalton Protein Interacts with the Mitogen-Activated Protein Kinase Scaffold Mp1 on a Late Endosomal/Lysosomal Compartment , 2001, The Journal of cell biology.

[39]  W. Hahn,et al.  Genes involved in senescence and immortalization. , 2000, Current opinion in cell biology.

[40]  Michael Loran Dustin,et al.  Signaling Takes Shape in the Immune System , 2000, Cell.

[41]  E. Nishida,et al.  A conserved docking motif in MAP kinases common to substrates, activators and regulators , 2000, Nature Cell Biology.

[42]  Tomas Mustelin,et al.  Crosstalk between cAMP-dependent kinase and MAP kinase through a protein tyrosine phosphatase , 1999, Nature Cell Biology.

[43]  Andrius Kazlauskas,et al.  Diverse Signaling Pathways Activated by Growth Factor Receptors Induce Broadly Overlapping, Rather Than Independent, Sets of Genes , 1999, Cell.

[44]  A. Gavin,et al.  A MAP kinase docking site is required for phosphorylation and activation of p90rsk/MAPKAP kinase-1 , 1999, Current Biology.

[45]  T. Sturgill,et al.  Identification of an Extracellular Signal-regulated Kinase (ERK) Docking Site in Ribosomal S6 Kinase, a Sequence Critical for Activation by ERK in Vivo * , 1999, The Journal of Biological Chemistry.

[46]  K Kornfeld,et al.  Multiple docking sites on substrate proteins form a modular system that mediates recognition by ERK MAP kinase. , 1999, Genes & development.

[47]  J. Bos All in the family? New insights and questions regarding interconnectivity of Ras, Rap1 and Ral , 1998, The EMBO journal.

[48]  M. Greenberg,et al.  Fos Family Members Induce Cell Cycle Entry by Activating Cyclin D1 , 1998, Molecular and Cellular Biology.

[49]  A. Brunet,et al.  Growth Factor–induced p42/p44 MAPK Nuclear Translocation and Retention Requires Both MAPK Activation and Neosynthesis of Nuclear Anchoring Proteins , 1998, The Journal of cell biology.

[50]  M. Muda,et al.  Catalytic activation of the phosphatase MKP-3 by ERK2 mitogen-activated protein kinase. , 1998, Science.

[51]  J E Ferrell,et al.  The biochemical basis of an all-or-none cell fate switch in Xenopus oocytes. , 1998, Science.

[52]  E. Mccleskey,et al.  Rap1 mediates sustained MAP kinase activation induced by nerve growth factor , 1998, Nature.

[53]  A. Sharrocks,et al.  The ETS-domain transcription factor family. , 1997, Nature reviews. Molecular cell biology.

[54]  C. Marshall,et al.  The influence of the MAPK pathway on T cell lineage commitment. , 1997, Immunity.

[55]  R. Kucherlapati,et al.  K-ras is an essential gene in the mouse with partial functional overlap with N-ras. , 1997, Genes & development.

[56]  E. Wagner,et al.  Structure and chromosomal assignment of the mouse fra-1 gene, and its exclusion as a candidate gene for oc (osteosclerosis) , 1997, Oncogene.

[57]  Jun Miyoshi,et al.  K-Ras is essential for the development of the mouse embryo , 1997, Oncogene.

[58]  E. Lees,et al.  Raf-induced proliferation or cell cycle arrest is determined by the level of Raf activity with arrest mediated by p21Cip1 , 1997, Molecular and cellular biology.

[59]  A Sewing,et al.  High-intensity Raf signal causes cell cycle arrest mediated by p21Cip1 , 1997, Molecular and cellular biology.

[60]  S. Cook,et al.  Regulation of Mitogen-activated Protein Kinase Phosphatase-1 Expression by Extracellular Signal-related Kinase-dependent and Ca2+-dependent Signal Pathways in Rat-1 Cells* , 1997, The Journal of Biological Chemistry.

[61]  N. Ahn,et al.  Megakaryocytic differentiation induced by constitutive activation of mitogen-activated protein kinase kinase , 1997, Molecular and cellular biology.

[62]  S. Schmid,et al.  Control of EGF Receptor Signaling by Clathrin-Mediated Endocytosis , 1996, Science.

[63]  J. Blenis,et al.  Phosphorylation of c-Fos at the C-terminus enhances its transforming activity. , 1996, Oncogene.

[64]  K. Okazaki,et al.  The Mos/MAP kinase pathway stabilizes c‐Fos by phosphorylation and augments its transforming activity in NIH 3T3 cells. , 1995, The EMBO journal.

[65]  J. Pouysségur,et al.  Constitutive MAP kinase phosphatase (MKP-1) expression blocks G1 specific gene transcription and S-phase entry in fibroblasts. , 1995, Oncogene.

[66]  C. Marshall,et al.  Specificity of receptor tyrosine kinase signaling: Transient versus sustained extracellular signal-regulated kinase activation , 1995, Cell.

[67]  F. C. Lucibello,et al.  Cell proliferation and cell cycle progression are not impaired in fibroblasts and ES cells lacking c-Fos. , 1995, Oncogene.

[68]  C. Marshall,et al.  The sevenmaker gain‐of‐function mutation in p42 MAP kinase leads to enhanced signalling and reduced sensitivity to dual specificity phosphatase action , 1994, FEBS letters.

[69]  N. Ahn,et al.  Transformation of mammalian cells by constitutively active MAP kinase kinase. , 1994, Science.

[70]  Ivan Dikic,et al.  PC12 cells overexpressing the insulin receptor undergo insulin-dependent neuronal differentiation , 1994, Current Biology.

[71]  P. Cohen,et al.  EGF triggers neuronal differentiation of PC12 cells that overexpress the EGF receptor , 1994, Current Biology.

[72]  C. Marshall,et al.  Activation of MAP kinase kinase is necessary and sufficient for PC12 differentiation and for transformation of NIH 3T3 cells , 1994, Cell.

[73]  Hong Sun,et al.  The growth factor-inducible immediate-early gene 3CH134 encodes a protein-tyrosine-phosphatase. , 1993, Proceedings of the National Academy of Sciences of the United States of America.

[74]  J. Blenis,et al.  Coordinate regulation of pp90rsk and a distinct protein-serine/threonine kinase activity that phosphorylates recombinant pp90rsk in vitro , 1991, Molecular and cellular biology.

[75]  I. Verma,et al.  Phosphorylation of the C terminus of Fos protein is required for transcriptional transrepression of the c-fos promoter , 1990, Nature.

[76]  L. Lau,et al.  Identification of a set of genes expressed during the G0/G1 transition of cultured mouse cells. , 1985, The EMBO journal.

[77]  M. Greenberg,et al.  Nerve growth factor and epidermal growth factor induce rapid transient changes in proto-oncogene transcription in PC12 cells. , 1985, The Journal of biological chemistry.

[78]  Michael E. Greenberg,et al.  Stimulation of 3T3 cells induces transcription of the c-fos proto-oncogene , 1984, Nature.

[79]  I. Verma,et al.  Viral and cellular fos proteins: A comparative analysis , 1984, Cell.

[80]  K. Simons,et al.  Cell biology. Ras on the roundabout. , 2005, Science.

[81]  Angus C. Nairn,et al.  NMDA-mediated activation of the tyrosine phosphatase STEP regulates the duration of ERK signaling , 2003, Nature Neuroscience.

[82]  D. Bar-Sagi,et al.  Activation of Ras and other signaling pathways by receptor tyrosine kinases. , 1994, Cold Spring Harbor symposia on quantitative biology.