Alkmaion’s discovery that brain creates mind: A revolution in human knowledge comparable to that of Copernicus and of Darwin

Without special examination the brain offers no clue that it is the organ of the mind. From the dawn of time man thus either ignored the problem as to the source of thought, or attributed it to a variety of anatomical structures, usually the heart. The brain held no place in such intuitions, and in most languages it is analogized to bone marrow. Furthermore, nothing in early medical systems claimed any intellectual capacity for the brain; and the Egyptians, so fastidious in care for their afterlife, heedlessly discarded the brain in funerary practice. It was thus a unique event in world history when Alkmaion of Kroton (Alcmaeon, ca. 500 bc), based on anatomical evidence, proposed that the brain was essential for perception. Although no writings of Alkmaion survived, it was probably via a fortuitous linkage that his idea of the mental primacy of the brain was transmitted to, and preserved within, the teachings of the Hippocratic school. Nothing, of course, was secure as to mechanism, two millennia unfolding until the search for mind passed from the ventricles to the cerebral cortex. Nonetheless, Alkmaion was the beginning, and the ensuing understanding that he initiated is still transforming humanity's perception of the natural world, and their place within it.

[1]  W. Guthrie.  A history of Greek philosophy , 1978 .

[2]  R. W. Doty.  Philosophy and the Brain , 2015, Perspectives in biology and medicine.

[3]  F. Gall,et al.  Anatomie et physiologie du système nerveux en général et du cerveau en particulier; avec des observations sur la possibilité de reconnaître plusieurs dispositions intellectuelles et morales de l’homme et des animaux par la configuration de leur têtes (Vol. 3) , 1810 .

[4]  W. Riese.  The 150th anniversary of S. T. Soemmerring's Organ of the soul; the reaction of his contemporaries and its significance today. , 1946, Bulletin of the history of medicine.

[5]  G. Lloyd.  Alcmaeon and the early history of dissection. , 1975, Sudhoffs Archiv.

[6]  Jonathan Barnes,et al.  The Presocratic Philosophers , 2018, Studies in Early Greek Philosophy.

[7]  D. Woollam,et al.  THE HISTORICAL SIGNIFICANCE OF THE CEREBROSPINAL FLUID , 1957, Medical History.

[8]  R L Buckner,et al.  Spatiotemporal Maps of Brain Activity Underlying Word Generation and Their Modification during Repetition Priming , 2001, The Journal of Neuroscience.

[9]  W. Verdenius.  H. GRENSEMANN, Die hippokratische Schrift Über die heilige Krankheit' (Ars Medica, II 1). Berlin, W. de Gruyter, 1968. XIV, 126 S. Pr. DM 42,- , 1973 .

[10]  G. Lloyd.  Methods and problems in Greek science , 1991 .

[11]  O. Grüsser,et al.  On the history of deformation phosphenes and the idea of internal light generated in the eye for the purpose of vision , 1990, Documenta Ophthalmologica.

[12]  Theophrastus and the Greek physiological psychology before Aristotle , 1964 .

[13]  S. Ochs.  A History of Nerve Functions: From Animal Spirits to Molecular Mechanisms , 2004 .

[14]  B. Halioua,et al.  Medicine in the days of the pharaohs , 2005 .

[15]  G. Kirk,et al.  The Presocratic Philosophers a Critical History with a Selection of Texts /by G.S. Kirk, J.E. Raven, M. Schofield. --. -- , 1957 .

[16]  F. M. Cornford.  Plato's Cosmology: The Timaeus of Plato Translated with a Running Commentary , 1937, Greece and Rome.

[17]  T. Manzoni.  The cerebral ventricles, the animal spirits and the dawn of brain localization of function. , 1998, Archives italiennes de biologie.

[18]  E. Tregear.  The Maori-Polynesian comparative dictionary , 2009 .

[19]  J. Longrigg.  Greek Rational Medicine: Philosophy and Medicine from Alcmaeon to the Alexandrians , 1993 .

[20]  Kenneth George Beauchamp,et al.  A History of Telegraphy , 2000 .

[21]  Wesley D. Smith,et al.  Aspects of Greek Medicine , 1987 .

[22]  J. Filliozat.  The classical doctrine of Indian medicine : its origins and its Greek parallels , 1964 .

[23]  E. Clarke,et al.  The human brain and spinal cord : a historical study illustrated by writings from antiquity to the twentieth century , 1968 .

[24]  Aristotelian concepts of the form and function of the brain. , 1963, Bulletin of the history of medicine.

[25]  Lesley Adkins,et al.  Handbook to life in Ancient Greece , 1997 .

[26]  P. Kutumbiah.  Ancient Indian Medicine , 1959 .

[27]  M. R. Wright,et al.  Empedocles, the extant fragments , 1981 .

[28]  W. Andrew.  The vertebrate visual system , 1957 .

[29]  HUANG TI NEI CHING SU WÈN: THE YELLOW EMPERORʼS CLASSIC OF INTERNAL MEDICINE , 1967 .

[30]  J. Rocca,et al.  Galen and the ventricular system. , 1997, Journal of the history of the neurosciences.

[31]  D. Sider,et al.  Herophilus: The Art of Medicine in Early Alexandria , 1989 .

[32]  R. Doty,et al.  The five mysteries of the mind, and their consequences , 1998, Neuropsychologia.

[33]  H. Grensemann,et al.  Die hippokratische Schrift "Über die heilige Krankheit" , 1968 .

[34]  E. Clarke.  APOPLEXY IN THE HIPPOCRATIC WRITINGS. , 1963, Bulletin of the history of medicine.

[35]  E. Craik.  The Dorian Aegean , 1980 .

[36]  D. Guthrie.  Anglo-Saxon Magic and Medicine , 1953, Nature.

[37]  S. Miyasita.  A Link in the Westward Transmission of Chinese Anatomy in the Later Middle Ages , 1967, Isis.

[38]  L. G. Wilson.  Erasistratus, Galen, and the pneuma. , 1959, Bulletin of the history of medicine.

[39]  P. Strick,et al.  Muscle representation in the macaque motor cortex: an anatomical perspective. , 2006, Proceedings of the National Academy of Sciences of the United States of America.

[40]  Stanley Finger,et al.  Origins of neuroscience: A history of explorations into brain function. , 1994 .

[41]  P. S. Codellas.  Alcmaeon of Croton: His Life, Work, and Fragments , 1932, Proceedings of the Royal Society of Medicine.

[42]  R. Moon.  Hippocrates and his successors in relation to the philosophy of their time : the Fitzpatrick lectures delivered at the Royal College of Physicians 1921-22 , 1940 .