BMP signalling: agony and antagony in the family.

[1]  Katsu Takahashi,et al.  Interactions between BMP-7 and USAG-1 (uterine sensitization-associated GENE-1) regulate formations of supernumerary maxillary incisors , 2015 .

[2]  E. Diamandis,et al.  Bone morphogenetic protein antagonist gremlin-1 regulates colon cancer progression , 2015, Biological chemistry.

[3]  C. Cheadle,et al.  RAP‐011, an activin receptor ligand trap, increases hemoglobin concentration in hepcidin transgenic mice , 2015, American journal of hematology.

[4]  C. Lindsley,et al.  Specific Activin Receptor–Like Kinase 3 Inhibitors Enhance Liver Regeneration , 2014, The Journal of Pharmacology and Experimental Therapeutics.

[5]  J. Giltnane,et al.  Abstract 2676: Inhibition of bmp signaling suppresses metastasis in mammary cancer , 2014 .

[6]  Xiao-qun Zhang,et al.  Regulation of pulmonary surfactant synthesis in fetal rat type II alveolar epithelial cells by microRNA‐26a , 2014, Pediatric pulmonology.

[7]  Zhiyong Yang,et al.  MicroRNA‐27b Targets Gremlin 1 to Modulate Fibrotic Responses in Pulmonary Cells , 2014, Journal of cellular biochemistry.

[8]  M. Sandri,et al.  TGFβ and BMP signaling in skeletal muscle: potential significance for muscle-related disease , 2014, Trends in Endocrinology & Metabolism.

[9]  T. Jowitt,et al.  Nanoscale structure of the BMP antagonist chordin supports cooperative BMP binding , 2014, Proceedings of the National Academy of Sciences.

[10]  Choung-Soo Kim,et al.  miR‐140‐5p suppresses BMP2‐mediated osteogenesis in undifferentiated human mesenchymal stem cells , 2014, FEBS letters.

[11]  Zhiguo Lin,et al.  miR-656 inhibits glioma tumorigenesis through repression of BMPR1A. , 2014, Carcinogenesis.

[12]  D. Constam Regulation of TGFβ and related signals by precursor processing. , 2014, Seminars in cell & developmental biology.

[13]  T. B. Thompson,et al.  The DAN family: Modulators of TGF‐β signaling and beyond , 2014, Protein science : a publication of the Protein Society.

[14]  D. Brazil,et al.  Bone morphogenetic proteins and their antagonists: current and emerging clinical uses , 2014, British journal of pharmacology.

[15]  Katsunori Yoshida,et al.  TGF-β/Smad signaling during hepatic fibro-carcinogenesis (Review) , 2014, International journal of oncology.

[16]  J. Egido,et al.  Tubular Overexpression of Gremlin Induces Renal Damage Susceptibility in Mice , 2014, PloS one.

[17]  J. Giltnane,et al.  Inhibition of BMP Signaling Suppresses Metastasis in Mammary Cancer , 2014, Oncogene.

[18]  Jodie L Babitt,et al.  MicroRNA-130a Is Up-regulated in Mouse Liver by Iron Deficiency and Targets the Bone Morphogenetic Protein (BMP) Receptor ALK2 to Attenuate BMP Signaling and Hepcidin Transcription* , 2014, The Journal of Biological Chemistry.

[19]  A. H. Campos,et al.  BMP-2 and -4 produced by vascular smooth muscle cells from atherosclerotic lesions induce monocyte chemotaxis through direct BMPRII activation. , 2014, Atherosclerosis.

[20]  E. Knapik,et al.  Gremlin 2 Promotes Differentiation of Embryonic Stem Cells to Atrial Fate by Activation of the JNK Signaling Pathway , 2014, Stem cells.

[21]  J. Seoane Gremlins sabotage the mechanisms of cancer stem cell differentiation. , 2014, Cancer cell.

[22]  J. Li,et al.  MicroRNA-885-3p inhibits the growth of HT-29 colon cancer cell xenografts by disrupting angiogenesis via targeting BMPR1A and blocking BMP/Smad/Id1 signaling , 2014, Oncogene.

[23]  P. Knaus,et al.  BMP2-induced chemotaxis requires PI3K p55γ/p110α-dependent phosphatidylinositol (3,4,5)-triphosphate production and LL5β recruitment at the cytocortex , 2014, BMC Biology.

[24]  Q. Kang,et al.  TGF-β2 induces transdifferentiation and fibrosis in human lens epithelial cells via regulating gremlin and CTGF. , 2014, Biochemical and biophysical research communications.

[25]  Qiulian Wu,et al.  Glioma cancer stem cells secrete Gremlin1 to promote their maintenance within the tumor hierarchy , 2014, Genes & development.

[26]  Yasuhiko Tabata,et al.  Interactions between BMP-7 and USAG-1 (Uterine Sensitization-Associated Gene-1) Regulate Supernumerary Organ Formations , 2014, PloS one.

[27]  B. Dawson,et al.  Excessive TGFβ signaling is a common mechanism in Osteogenesis Imperfecta , 2014, Nature Medicine.

[28]  H. Jung,et al.  Failure of Tooth Formation Mediated by miR-135a Overexpression via BMP Signaling , 2014, Journal of dental research.

[29]  N. Nakano,et al.  C18 ORF1, a Novel Negative Regulator of Transforming Growth Factor-β Signaling* , 2014, The Journal of Biological Chemistry.

[30]  S. Wölfl,et al.  Neuroprotection by rAAV-mediated gene transfer of bone morphogenic protein 7 , 2014, BMC Neuroscience.

[31]  Chun Cheng,et al.  Asparagine-linked glycosylation of bone morphogenetic protein-2 is required for secretion and osteoblast differentiation. , 2014, Glycobiology.

[32]  Anindya Dutta,et al.  The H19 long noncoding RNA gives rise to microRNAs miR-675-3p and miR-675-5p to promote skeletal muscle differentiation and regeneration , 2014, Genes & development.

[33]  N. Katsanis,et al.  Novel bone morphogenetic protein signaling through Smad2 and Smad3 to regulate cancer progression and development , 2014, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[34]  I. Pastan,et al.  Twisted Gastrulation, a BMP Antagonist, Exacerbates Podocyte Injury , 2014, PloS one.

[35]  A. Masamune,et al.  MiR-365 induces gemcitabine resistance in pancreatic cancer cells by targeting the adaptor protein SHC1 and pro-apoptotic regulator BAX. , 2014, Cellular signalling.

[36]  G. Sapkota,et al.  Protein associated with SMAD1 (PAWS1/FAM83G) is a substrate for type I bone morphogenetic protein receptors and modulates bone morphogenetic protein signalling , 2014, Open Biology.

[37]  R. Trivedi,et al.  miR-542-3p suppresses osteoblast cell proliferation and differentiation, targets BMP-7 signaling and inhibits bone formation , 2014, Cell Death and Disease.

[38]  Ning Zhang,et al.  MiR-30b is involved in methylglyoxal-induced epithelial-mesenchymal transition of peritoneal mesothelial cells in rats , 2014, Cellular & Molecular Biology Letters.

[39]  R. Xiang,et al.  BMP-6 inhibits cell proliferation by targeting microRNA-192 in breast cancer. , 2013, Biochimica et biophysica acta.

[40]  R. Liao,et al.  MicroRNA-26a Regulates Pathological and Physiological Angiogenesis by Targeting BMP/SMAD1 Signaling , 2013, Circulation research.

[41]  N. Morrell,et al.  Treatment with anti-gremlin 1 antibody ameliorates chronic hypoxia/SU5416-induced pulmonary arterial hypertension in mice. , 2013, The American journal of pathology.

[42]  T. Fotsis,et al.  SARA and RNF11 interact with each other and ESCRT-0 core proteins and regulate degradative EGFR trafficking , 2013, Oncogene.

[43]  Antony Rodriguez,et al.  MicroRNA-22 Is a Master Regulator of Bone Morphogenetic Protein-7/6 Homeostasis in the Kidney* , 2013, The Journal of Biological Chemistry.

[44]  N. Morrell,et al.  Genetics and the Molecular Pathogenesis of Pulmonary Arterial Hypertension , 2013, Current Hypertension Reports.

[45]  P. Schmieder,et al.  The Clip-Segment of the von Willebrand Domain 1 of the BMP Modulator Protein Crossveinless 2 Is Preformed , 2013, Molecules.

[46]  Y. Li,et al.  Gremlin aggravates hyperglycemia‐induced podocyte injury by a TGFβ/smad dependent signaling pathway , 2013, Journal of cellular biochemistry.

[47]  Michael T. McManus,et al.  The Pitx2:miR-200c/141:noggin pathway regulates Bmp signaling and ameloblast differentiation , 2013, Development.

[48]  Xiaodi A Deng,et al.  Structure of protein related to Dan and Cerberus: insights into the mechanism of bone morphogenetic protein antagonism. , 2013, Structure.

[49]  Anirudh Sethi,et al.  Gremlin utilizes canonical and non-canonical TGFβ signaling to induce lysyl oxidase (LOX) genes in human trabecular meshwork cells. , 2013, Experimental eye research.

[50]  E. Diamandis,et al.  Enrichment map profiling of the cancer invasion front suggests regulation of colorectal cancer progression by the bone morphogenetic protein antagonist, gremlin‐1 , 2013, Molecular oncology.

[51]  M. Varjosalo,et al.  Gremlin-1 associates with fibrillin microfibrils in vivo and regulates mesothelioma cell survival through transcription factor slug , 2013, Oncogenesis.

[52]  D. Bernstein,et al.  FK506 activates BMPR2, rescues endothelial dysfunction, and reverses pulmonary hypertension. , 2013, The Journal of clinical investigation.

[53]  C. Bode,et al.  Antagonism and synergy between extracellular BMP modulators Tsg and BMPER balance blood vessel formation , 2013, Journal of Cell Science.

[54]  A. Burlingame,et al.  Arginine Methylation Initiates BMP-Induced Smad Signaling. , 2013, Molecular cell.

[55]  N. Epstein,et al.  Complications due to the use of BMP/INFUSE in spine surgery: The evidence continues to mount , 2013, Surgical neurology international.

[56]  A. Brivanlou,et al.  Regarding the mechanism of action of a proposed peptide agonist of the bone morphogenetic protein receptor activin-like kinase 3 , 2013, Nature Medicine.

[57]  M. Konopleva,et al.  TGF-β-Neutralizing Antibody 1D11 Enhances Cytarabine-Induced Apoptosis in AML Cells in the Bone Marrow Microenvironment , 2013, PloS one.

[58]  R. Mohan,et al.  BMP7 Gene Transfer via Gold Nanoparticles into Stroma Inhibits Corneal Fibrosis In Vivo , 2013, PloS one.

[59]  Rushikesh Sheth,et al.  Decoupling the function of Hox and Shh in developing limb reveals multiple inputs of Hox genes on limb growth , 2013, Development.

[60]  C. Pollock,et al.  MiRNA-200b represses transforming growth factor-β1-induced EMT and fibronectin expression in kidney proximal tubular cells. , 2013, American journal of physiology. Renal physiology.

[61]  A. Bullock,et al.  A New Class of Small Molecule Inhibitor of BMP Signaling , 2013, PloS one.

[62]  Y. Mishina,et al.  Constitutively Active ALK2 Receptor Mutants Require Type II Receptor Cooperation , 2013, Molecular and Cellular Biology.

[63]  E. Brennan,et al.  Lipoxins attenuate renal fibrosis by inducing let-7c and suppressing TGFβR1. , 2013, Journal of the American Society of Nephrology : JASN.

[64]  M. Myllärniemi,et al.  Bone morphogenetic protein-inducer tilorone identified by high-throughput screening is antifibrotic in vivo. , 2013, American journal of respiratory cell and molecular biology.

[65]  P. Zhang,et al.  Kielin/chordin-like protein attenuates both acute and chronic renal injury. , 2013, Journal of the American Society of Nephrology : JASN.

[66]  Michael R. Taylor,et al.  Identification of Small Molecule Activators of BMP Signaling , 2013, PloS one.

[67]  A. Ortiz,et al.  Gremlin Is a Downstream Profibrotic Mediator of Transforming Growth Factor-Beta in Cultured Renal Cells , 2013, Nephron Experimental Nephrology.

[68]  A. Meng,et al.  MicroRNA-92a upholds Bmp signaling by targeting noggin3 during pharyngeal cartilage formation. , 2013, Developmental cell.

[69]  Haixia Huang,et al.  Gremlin induces cell proliferation and extra cellular matrix accumulation in mouse mesangial cells exposed to high glucose via the ERK1/2 pathway , 2013, BMC Nephrology.

[70]  S. Wölfl,et al.  Quantitative kinetics analysis of BMP2 uptake into cells and its modulation by BMP antagonists , 2013, Journal of Cell Science.

[71]  A. Zorn,et al.  Members of the DAN family are BMP antagonists that form highly stable noncovalent dimers. , 2012, Journal of molecular biology.

[72]  Z. Hao,et al.  Oral administration of recombinant adeno-associated virus-mediated bone morphogenetic protein-7 suppresses CCl(4)-induced hepatic fibrosis in mice. , 2012, Molecular therapy : the journal of the American Society of Gene Therapy.

[73]  N. Katsanis,et al.  Endoglin mediates fibronectin/α5β1 integrin and TGF‐β pathway crosstalk in endothelial cells , 2012, The EMBO journal.

[74]  Anindya Dutta,et al.  miR-26a is required for skeletal muscle differentiation and regeneration in mice. , 2012, Genes & development.

[75]  B. Davis-Dusenbery,et al.  Inhibition of MicroRNA-302 (miR-302) by Bone Morphogenetic Protein 4 (BMP4) Facilitates the BMP Signaling Pathway* , 2012, The Journal of Biological Chemistry.

[76]  A. Economides,et al.  Inactivation of the dual Bmp/Wnt inhibitor Sostdc1 enhances pancreatic islet function. , 2012, American journal of physiology. Endocrinology and metabolism.

[77]  Stefan Knapp,et al.  Structure of the Bone Morphogenetic Protein Receptor ALK2 and Implications for Fibrodysplasia Ossificans Progressiva , 2012, The Journal of Biological Chemistry.

[78]  Z. Strasky,et al.  The role of endoglin in atherosclerosis. , 2012, Atherosclerosis.

[79]  Jing Li,et al.  miR-155 modulates TNF-α-inhibited osteogenic differentiation by targeting SOCS1 expression. , 2012, Bone.

[80]  H. Schnaper,et al.  Phosphatidylinositol 3-Kinase and Rab5 GTPase Inversely Regulate the Smad Anchor for Receptor Activation (SARA) Protein Independently of Transforming Growth Factor-β1 , 2012, The Journal of Biological Chemistry.

[81]  A. Brivanlou,et al.  The BMP Inhibitor Coco Reactivates Breast Cancer Cells at Lung Metastatic Sites , 2012, Cell.

[82]  M. Barcellos-Hoff,et al.  Resistance of glioblastoma-initiating cells to radiation mediated by the tumor microenvironment can be abolished by inhibiting transforming growth factor-β. , 2012, Cancer research.

[83]  N. Baddour,et al.  Gremlin in the pathogenesis of hepatocellular carcinoma complicating chronic hepatitis C: an immunohistochemical and PCR study of human liver biopsies , 2012, BMC Research Notes.

[84]  C. Hopkins,et al.  DMH1, a Novel BMP Small Molecule Inhibitor, Increases Cardiomyocyte Progenitors and Promotes Cardiac Differentiation in Mouse Embryonic Stem Cells , 2012, PloS one.

[85]  Jinghong Zhao,et al.  Gremlin-mediated decrease in bone morphogenetic protein signaling promotes aristolochic acid-induced epithelial-to-mesenchymal transition (EMT) in HK-2 cells. , 2012, Toxicology.

[86]  Z. Hao,et al.  Intracolonically administered adeno‐associated virus‐bone morphogenetic protein‐7 ameliorates dextran sulphate sodium‐induced acute colitis in rats , 2012, The journal of gene medicine.

[87]  Tao Yang,et al.  Bone morphogenetic protein 7 suppresses the progression of hepatic fibrosis and regulates the expression of gremlin and transforming growth factor β1. , 2012, Molecular medicine reports.

[88]  E. Bottinger,et al.  BAMBI Regulates Angiogenesis and Endothelial Homeostasis through Modulation of Alternative TGFβ Signaling , 2012, PloS one.

[89]  S. Dupont,et al.  Signaling crosstalk between TGFβ and Dishevelled/Par1b , 2012, Cell Death and Differentiation.

[90]  C. Hong,et al.  BMP2 signals loss of epithelial character in epicardial cells but requires the Type III TGFβ receptor to promote invasion. , 2012, Cellular signalling.

[91]  G. Seki,et al.  3-Hydroxy-3-methylglutaryl-coenzyme A reductase inhibitor simvastatin ameliorates renal fibrosis through HOXA13–USAG-1 pathway , 2012, Laboratory Investigation.

[92]  J. Kim,et al.  Gremlin-1 Induces BMP-Independent Tumor Cell Proliferation, Migration, and Invasion , 2012, PloS one.

[93]  D. Brazil,et al.  Deletion of Gremlin1 increases cell proliferation and migration responses in mouse embryonic fibroblasts. , 2012, Cellular signalling.

[94]  Kenichi Sugihara,et al.  Microarray Analysis of Colorectal Cancer Stromal Tissue Reveals Upregulation of Two Oncogenic miRNA Clusters , 2012, Clinical Cancer Research.

[95]  Albert-László Barabási,et al.  MicroRNA-21 Integrates Pathogenic Signaling to Control Pulmonary Hypertension: Results of a Network Bioinformatics Approach , 2012, Circulation.

[96]  M. Leonard,et al.  Gremlin Plays a Key Role in the Pathogenesis of Pulmonary Hypertension , 2012, Circulation.

[97]  V. Rubio,et al.  Structural and Functional Insights into Endoglin Ligand Recognition and Binding , 2012, PloS one.

[98]  R. Kalluri,et al.  Activin–like kinase–3 activity is important for kidney regeneration and reversal of fibrosis , 2012, Nature Medicine.

[99]  Haibo Zhou,et al.  miR-30 Family Members Negatively Regulate Osteoblast Differentiation* , 2012, The Journal of Biological Chemistry.

[100]  A. Economides,et al.  Loss of Gremlin Delays Primordial Follicle Assembly but Does Not Affect Female Fertility in Mice1 , 2011, Biology of reproduction.

[101]  M. Rusnati,et al.  Heparan Sulfate Proteoglycans Mediate the Angiogenic Activity of the Vascular Endothelial Growth Factor Receptor-2 Agonist Gremlin , 2011, Arteriosclerosis, thrombosis, and vascular biology.

[102]  A. Sharov,et al.  MicroRNA-21 is an important downstream component of BMP signalling in epidermal keratinocytes , 2011, Development.

[103]  D. Graf,et al.  Compartmentalization of bone morphogenetic proteins and their antagonists in lymphoid progenitors and supporting microenvironments and functional implications , 2011, Immunology.

[104]  C. Sander,et al.  Genome-wide identification of microRNA targets in human ES cells reveals a role for miR-302 in modulating BMP response. , 2011, Genes & development.

[105]  A. Sharov,et al.  MicroRNA-21 is an important downstream component of BMP signalling in epidermal keratinocytes , 2011, Journal of Cell Science.

[106]  A. Politou,et al.  ERBIN is a new SARA-interacting protein: competition between SARA and SMAD2 and SMAD3 for binding to ERBIN , 2011, Journal of Cell Science.

[107]  C. Patterson,et al.  Bone Morphogenetic Protein Endothelial Cell Precursor–Derived Regulator Regulates Retinal Angiogenesis In Vivo in a Mouse Model of Oxygen-Induced Retinopathy , 2011, Arteriosclerosis, thrombosis, and vascular biology.

[108]  A. Sculean,et al.  A phase IIa randomized controlled pilot study evaluating the safety and clinical outcomes following the use of rhGDF-5/β-TCP in regenerative periodontal therapy , 2011, Clinical Oral Investigations.

[109]  Anirudh Sethi,et al.  Role of TGFbeta/Smad signaling in gremlin induction of human trabecular meshwork extracellular matrix proteins. , 2011, Investigative ophthalmology & visual science.

[110]  M. O’Connor,et al.  Involvement of Twisted Gastrulation in T Cell-Independent Plasma Cell Production , 2011, The Journal of Immunology.

[111]  D. Warburton,et al.  Transient overexpression of Gremlin results in epithelial activation and reversible fibrosis in rat lungs. , 2011, American journal of respiratory cell and molecular biology.

[112]  R. Goldschmeding,et al.  Lipoxin A4 and benzo‐lipoxin A4 attenuate experimental renal fibrosis , 2011, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[113]  R. Zeller,et al.  Genetic Analysis Reveals an Unexpected Role of BMP7 in Initiation of Ureteric Bud Outgrowth in Mouse Embryos , 2011, PloS one.

[114]  Eileen M. Shore,et al.  In vitro Analyses of the Dysregulated R206H ALK2 Kinase-FKBP12 Interaction Associated with Heterotopic Ossification in FOP , 2011, Cells Tissues Organs.

[115]  H. Uchi,et al.  Lipoxin A(4), a potential anti-inflammatory drug targeting the skin. , 2011, Journal of dermatological science.

[116]  M. Khokha,et al.  Cooperative activity of noggin and gremlin 1 in axial skeleton development , 2011, Development.

[117]  R. Goldschmeding,et al.  Loss of endogenous bone morphogenetic protein-6 aggravates renal fibrosis. , 2011, The American journal of pathology.

[118]  Robert H. Jenkins,et al.  BMP-6 emerges as a potential major regulator of fibrosis in the kidney. , 2011, The American journal of pathology.

[119]  H. Abboud,et al.  Reactive oxygen species derived from Nox4 mediate BMP2 gene transcription and osteoblast differentiation. , 2011, The Biochemical journal.

[120]  L. Zammataro,et al.  Gremlin is a novel agonist of the major proangiogenic receptor VEGFR2. , 2010, Blood.

[121]  P. Knaus,et al.  Dorsomorphin and LDN-193189 inhibit BMP-mediated Smad, p38 and Akt signalling in C2C12 cells. , 2010, International Journal of Biochemistry and Cell Biology.

[122]  J. Jin,et al.  Bone morphogenetic protein-7 inhibits vascular calcification induced by high vitamin D in mice. , 2010, The Tohoku journal of experimental medicine.

[123]  H. Duan,et al.  In Vivo Delivery of Gremlin siRNA Plasmid Reveals Therapeutic Potential against Diabetic Nephropathy by Recovering Bone Morphogenetic Protein-7 , 2010, PloS one.

[124]  B. Mulloy,et al.  Bone morphogenetic protein and growth differentiation factor cytokine families and their protein antagonists. , 2010, The Biochemical journal.

[125]  Y. Akao,et al.  MicroRNA-208 Modulates BMP-2-stimulated Mouse Preosteoblast Differentiation by Directly Targeting V-ets Erythroblastosis Virus E26 Oncogene Homolog 1* , 2010, The Journal of Biological Chemistry.

[126]  D. Brazil,et al.  Extracellular BMP-antagonist regulation in development and disease: tied up in knots. , 2010, Trends in cell biology.

[127]  M. Loh,et al.  EGF-induced tyrosine phosphorylation of Endofin is dependent on PI3K activity and proper localization to endosomes. , 2010, Cellular signalling.

[128]  T. Sakurai,et al.  Loss of the BMP antagonist USAG-1 ameliorates disease in a mouse model of the progressive hereditary kidney disease Alport syndrome. , 2010, The Journal of clinical investigation.

[129]  C. Lindsley,et al.  In vivo structure-activity relationship study of dorsomorphin analogues identifies selective VEGF and BMP inhibitors. , 2010, ACS chemical biology.

[130]  J. Lieberman,et al.  Molecular basis for antagonism between PDGF and the TGFβ family of signalling pathways by control of miR‐24 expression , 2010, The EMBO journal.

[131]  W. Sebald,et al.  Intricacies of BMP receptor assembly. , 2009, Cytokine & growth factor reviews.

[132]  H. Luder,et al.  Deletion of BMP7 affects the development of bones, teeth, and other ectodermal appendages of the orofacial complex. , 2009, Journal of experimental zoology. Part B, Molecular and developmental evolution.

[133]  F. Farrell,et al.  BMP-7 fails to attenuate TGF-beta1-induced epithelial-to-mesenchymal transition in human proximal tubule epithelial cells. , 2009, Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association.

[134]  R. Goldschmeding,et al.  Allelic Depletion of grem1 Attenuates Diabetic Kidney Disease , 2009, Diabetes.

[135]  S. Mundlos,et al.  Classic and atypical fibrodysplasia ossificans progressiva (FOP) phenotypes are caused by mutations in the bone morphogenetic protein (BMP) type I receptor ACVR1 , 2009, Human mutation.

[136]  S. Vukicevic,et al.  BMP6 is a key endogenous regulator of hepcidin expression and iron metabolism , 2009, Nature Genetics.

[137]  L. Attisano,et al.  A concentration-dependent endocytic trap and sink mechanism converts Bmper from an activator to an inhibitor of Bmp signaling , 2009, The Journal of cell biology.

[138]  R. Derynck,et al.  TGFβ‐stimulated Smad1/5 phosphorylation requires the ALK5 L45 loop and mediates the pro‐migratory TGFβ switch , 2009, The EMBO journal.

[139]  D. Knight,et al.  BMP-7 Does Not Protect against Bleomycin-Induced Lung or Skin Fibrosis , 2008, PloS one.

[140]  T. Anada,et al.  Oversulfated chondroitin sulfate‐E binds to BMP‐4 and enhances osteoblast differentiation , 2008, Journal of cellular physiology.

[141]  Tomokazu Fukuda,et al.  BMP type I receptor inhibition reduces heterotopic ossification , 2008, Nature Medicine.

[142]  R. Peterson,et al.  Dorsomorphin, a Selective Small Molecule Inhibitor of BMP Signaling, Promotes Cardiomyogenesis in Embryonic Stem Cells , 2008, PloS one.

[143]  J. Engelhardt,et al.  Aggressive melanoma cells escape from BMP7-mediated autocrine growth inhibition through coordinated Noggin upregulation , 2008, Laboratory Investigation.

[144]  O. Eickelberg,et al.  Lung-selective gene responses to alveolar hypoxia: potential role for the bone morphogenetic antagonist gremlin in pulmonary hypertension. , 2008, American journal of physiology. Lung cellular and molecular physiology.

[145]  A. Kotzsch,et al.  Crystal structure analysis reveals how the Chordin family member crossveinless 2 blocks BMP-2 receptor binding. , 2008, Developmental cell.

[146]  G. Blobe,et al.  Bone Morphogenetic Proteins Signal through the Transforming Growth Factor-β Type III Receptor* , 2008, Journal of Biological Chemistry.

[147]  T. Oury,et al.  Gremlin-mediated decrease in bone morphogenetic protein signaling promotes pulmonary fibrosis. , 2008, American journal of respiratory and critical care medicine.

[148]  A. Murphy,et al.  Expression of BMP-7 and USAG-1 (a BMP antagonist) in kidney development and injury. , 2008, Kidney international.

[149]  J. Bok,et al.  Role of hindbrain in inner ear morphogenesis: analysis of Noggin knockout mice. , 2007, Developmental biology.

[150]  C. O'brien,et al.  The role of gremlin, a BMP antagonist, and epithelial-to-mesenchymal transition in proliferative vitreoretinopathy. , 2007, Investigative ophthalmology & visual science.

[151]  Xueli Yuan,et al.  Endothelial-to-mesenchymal transition contributes to cardiac fibrosis , 2007, Nature Medicine.

[152]  R. Zellweger,et al.  BONE MORPHOGENETIC PROTEINS IN CLINICAL APPLICATIONS , 2007, ANZ journal of surgery.

[153]  J. Wozney,et al.  Role of RGM coreceptors in bone morphogenetic protein signaling , 2007, Journal of molecular signaling.

[154]  R. Zeller,et al.  Reduction of BMP4 activity by gremlin 1 enables ureteric bud outgrowth and GDNF/WNT11 feedback signalling during kidney branching morphogenesis , 2007, Development.

[155]  R. Kalluri,et al.  Renal Fibrosis and Glomerulosclerosis in a New Mouse Model of Diabetic Nephropathy and Its Regression by Bone Morphogenic Protein-7 and Advanced Glycation End Product Inhibitors , 2007, Diabetes.

[156]  Xu Cao,et al.  Endofin acts as a Smad anchor for receptor activation in BMP signaling , 2007, Journal of Cell Science.

[157]  Howard Y. Chang,et al.  Bone morphogenetic protein antagonist gremlin 1 is widely expressed by cancer-associated stromal cells and can promote tumor cell proliferation , 2006, Proceedings of the National Academy of Sciences.

[158]  D. Warburton,et al.  BMP4 Activation and Secretion Are Negatively Regulated by an Intracellular Gremlin-BMP4 Interaction* , 2006, Journal of Biological Chemistry.

[159]  T. Jardetzky,et al.  The structural basis of TGF-beta, bone morphogenetic protein, and activin ligand binding. , 2006, Reproduction.

[160]  K. Lewis,et al.  Identification of distinct inhibin and transforming growth factor beta-binding sites on betaglycan: functional separation of betaglycan co-receptor actions. , 2006, The Journal of biological chemistry.

[161]  P. Bosma,et al.  Transcriptional Profiling Reveals Novel Markers of Liver Fibrogenesis , 2006, Journal of Biological Chemistry.

[162]  G. Dressler,et al.  The Cysteine-Rich Domain Protein KCP Is a Suppressor of Transforming Growth Factor β/Activin Signaling in Renal Epithelia , 2006, Molecular and Cellular Biology.

[163]  S. Choe,et al.  Structure of the ternary signaling complex of a TGF-β superfamily member , 2006, Proceedings of the National Academy of Sciences of the United States of America.

[164]  Raymond T Chung,et al.  Bone morphogenetic protein signaling by hemojuvelin regulates hepcidin expression , 2006, Nature Genetics.

[165]  C. Robinson,et al.  Structural basis for the inhibition of activin signalling by follistatin , 2006, The EMBO journal.

[166]  J. Massagué,et al.  Smad transcription factors. , 2005, Genes & development.

[167]  C. O'brien,et al.  Gremlin gene expression in bovine retinal pericytes exposed to elevated glucose , 2005, British Journal of Ophthalmology.

[168]  R. Derynck,et al.  SPECIFICITY AND VERSATILITY IN TGF-β SIGNALING THROUGH SMADS , 2005 .

[169]  Robert W Cook,et al.  The structure of the follistatin:activin complex reveals antagonism of both type I and type II receptor binding. , 2005, Developmental cell.

[170]  G. Dressler,et al.  Kielin/chordin-like protein, a novel enhancer of BMP signaling, attenuates renal fibrotic disease , 2005, Nature Medicine.

[171]  Jane Y. Wu,et al.  Cutting Edge: Bone Morphogenetic Protein Antagonists Drm/Gremlin and Dan Interact with Slits and Act as Negative Regulators of Monocyte Chemotaxis12 , 2004, The Journal of Immunology.

[172]  R. Zeller,et al.  Gremlin-mediated BMP antagonism induces the epithelial-mesenchymal feedback signaling controlling metanephric kidney and limb organogenesis , 2004, Development.

[173]  W. Sebald,et al.  Molecular recognition of BMP-2 and BMP receptor IA , 2004, Nature Structural &Molecular Biology.

[174]  R. Kalluri,et al.  Bone morphogenic protein-7 inhibits progression of chronic renal fibrosis associated with two genetic mouse models. , 2003, American journal of physiology. Renal physiology.

[175]  C. Hensey,et al.  Gremlin – a putative pathogenic player in progressive renal disease , 2003, Expert opinion on therapeutic targets.

[176]  M. Khokha,et al.  Gremlin is the BMP antagonist required for maintenance of Shh and Fgf signals during limb patterning , 2003, Nature Genetics.

[177]  Markus Affolter,et al.  Structural basis of BMP signalling inhibition by the cystine knot protein Noggin , 2002, Nature.

[178]  J. Massagué,et al.  Direct Binding of Smad1 and Smad4 to Two Distinct Motifs Mediates Bone Morphogenetic Protein-specific Transcriptional Activation ofId1 Gene* , 2002, The Journal of Biological Chemistry.

[179]  F. Luft,et al.  Amelioration of Angiotensin II–Induced Cardiac Injury by a 3-Hydroxy-3-Methylglutaryl Coenzyme A Reductase Inhibitor , 2001, Circulation.

[180]  M. Whitman,et al.  Nodal signals to Smads through Cripto-dependent and Cripto-independent mechanisms. , 2001, Molecular cell.

[181]  M. Taal,et al.  IHG-2, a Mesangial Cell Gene Induced by High Glucose, Is Human gremlin , 2000, The Journal of Biological Chemistry.

[182]  W. Sebald,et al.  Crystal structure of human bone morphogenetic protein-2 at 2.7 A resolution. , 1999, Journal of molecular biology.

[183]  F. Martin,et al.  Suppression Subtractive Hybridization Identifies High Glucose Levels as a Stimulus for Expression of Connective Tissue Growth Factor and Other Genes in Human Mesangial Cells* , 1999, The Journal of Biological Chemistry.

[184]  Liliana Attisano,et al.  SARA, a FYVE Domain Protein that Recruits Smad2 to the TGFβ Receptor , 1998, Cell.

[185]  G. Thomas,et al.  BMP‐4 is proteolytically activated by furin and/or PC6 during vertebrate embryonic development , 1998, The EMBO journal.

[186]  S. Vukicevic,et al.  Osteogenic protein-1 (bone morphogenetic protein-7) reduces severity of injury after ischemic acute renal failure in rat. , 1998, The Journal of clinical investigation.

[187]  M. Urist Bone: Formation by Autoinduction , 1965, Science.

[188]  S. Khan,et al.  The effects of Gremlin1 on human umbilical cord blood hematopoietic progenitors. , 2015, Blood cells, molecules & diseases.

[189]  H. Deng,et al.  Wnt/β-catenin signaling activates bone morphogenetic protein 2 expression in osteoblasts. , 2013, Bone.

[190]  Chi-Ying F. Huang,et al.  Expression of gremlin 1 correlates with increased angiogenesis and progression-free survival in patients with pancreatic neuroendocrine tumors , 2012, Journal of Gastroenterology.

[191]  Z. Hao,et al.  Oral Administration of Recombinant Adeno-associated Virus-mediated Bone Morphogenetic Protein-7 Suppresses CCl4-induced Hepatic Fibrosis in Mice. , 2012, Molecular therapy : the journal of the American Society of Gene Therapy.

[192]  M. Presta,et al.  Involvement of αvβ3 integrin in gremlin-induced angiogenesis , 2012, Angiogenesis.

[193]  R. Randall,et al.  Transforming Growth Factor (cid:1) Inhibits Bone Morphogenetic Protein-Induced Transcription through Novel Phosphorylated Smad1/5-Smad3 Complexes , 2022 .

[194]  R. Goldschmeding,et al.  Lipoxin A 4 and benzo-lipoxin A 4 attenuate experimental renal fibrosis , 2011 .

[195]  K. Miyazono,et al.  Bone morphogenetic protein receptors and signal transduction. , 2010, Journal of biochemistry.

[196]  A. Economides,et al.  Generation and functional characterization of mice with a conditional BMP7 allele. , 2009, The International journal of developmental biology.

[197]  田中 麻理 Expression of BMP-7 and USAG-1 (a BMP antagonist) in kidney development and injury , 2009 .

[198]  M. Raza Gremlin-mediated Decrease in Bone Morphogenetic Protein Signaling Promotes Pulmonary Fibrosis , 2009 .

[199]  Charles C Hong,et al.  Dorsomorphin inhibits BMP signals required for embryogenesis and iron metabolism. , 2008, Nature chemical biology.

[200]  R. Randall,et al.  Transforming Growth Factor (cid:2) -Induced Smad1/5 Phosphorylation in Epithelial Cells Is Mediated by Novel Receptor Complexes and Is Essential for Anchorage-Independent Growth (cid:1) † , 2008 .

[201]  R. Derynck,et al.  Specificity and versatility in tgf-beta signaling through Smads. , 2005, Annual review of cell and developmental biology.

[202]  O. Avsian-Kretchmer,et al.  Comparative genomic analysis of the eight-membered ring cystine knot-containing bone morphogenetic protein antagonists. , 2004, Molecular endocrinology.

[203]  S. Klahr,et al.  Bone morphogenetic protein-7 improves renal fibrosis and accelerates the return of renal function. , 2002, Journal of the American Society of Nephrology : JASN.