Activation of Hageman Factor (Factor XII) by Long-Chain Saturated Fatty Acids

Summary 1. Long-chain saturated fatty acids accelerate the clotting of blood by activating Hageman factor (HF, factor XII). Their effect is proportional to their chain length. 2. The hypothesis is discussed that long-chain saturated fatty acids in the circulating blood of man may exert a similar effect, and may thus be one of the factors in the etiology of clinical thrombosis.

[1]  W. Connor,et al.  Massive thrombosis produced by fatty acid infusion. , 1963, The Journal of clinical investigation.

[2]  P. Didisheim.  Hageman factor deficiency (Hageman trait). Case report and review of the literature. , 1962, Archives of internal medicine.

[3]  W. Connor,et al.  THE ACCELERATION OF THROMBUS FORMATION BY CERTAIN FATTY ACIDS. , 1962, The Journal of clinical investigation.

[4]  W. Connor,et al.  The effect of fatty acids on the formation of thrombi. , 1961, Quarterly journal of experimental physiology and cognate medical sciences.

[5]  J. O'Brien.  The effect of some fatty acids and phospholipids on blood coagulation. , 1957, British journal of experimental pathology.

[6]  J. Poole.  The effect of certain fatty acids on the coagulation of plasma in vitro. , 1955, British journal of experimental pathology.

[7]  J. B. Duguid.  Thrombosis as a factor in the pathogenesis of coronary atherosclerosis. , 1946, The Journal of pathology and bacteriology.

[8]  J. Ygge,et al.  Mechanism of the clot-promoting effect of fatty acids and synthetic anionic detergents. , 1961, Scandinavian journal of clinical and laboratory investigation.

[9]  S. Rapaport.  Evidence that glass increases plasma PTA activity. , 1958, The Journal of laboratory and clinical medicine.

[10]  T. Pilkington.  The effect of fatty acids and detergents on the calcium clotting time of human plasma. , 1957, Clinical science.