Electron Avenue Pathways of Disulfide Bond Formation and Isomerization

extracytoplasmic environments (e.g., the lumen of the eukaryotic endoplasmic reticulum and the gram-negative bacterial periplasmic space). In contrast, the cytoplasm displays a network of enzymes and molecules dedicated to the reduction of disulfide bonds (Åslund Laurent Debarbieux and Jon Beckwith* Department of Microbiology and Molecular Genetics Harvard Medical School Boston, Massachusetts 02115

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