Multifunctional Chitosan Nanoparticles for Tumor Imaging and Therapy

[1]  Ying Song,et al.  Modular polymer-caged nanobins as a theranostic platform with enhanced magnetic resonance relaxivity and pH-responsive drug release. , 2010, Angewandte Chemie.

[2]  Probal Banerjee,et al.  Chitosan-based responsive hybrid nanogels for integration of optical pH-sensing, tumor cell imaging and controlled drug delivery. , 2010, Biomaterials.

[3]  T. Aminabhavi,et al.  Chitosan as a carrier for targeted delivery of small interfering RNA. , 2010, International journal of pharmaceutics.

[4]  David C. Zhu,et al.  Hyaluronic acid immobilized magnetic nanoparticles for active targeting and imaging of macrophages. , 2010, Bioconjugate chemistry.

[5]  H. Takeuchi,et al.  Nanoparticles of glycol chitosan and its thiolated derivative significantly improved the pulmonary delivery of calcitonin. , 2010, International journal of pharmaceutics.

[6]  Ick Chan Kwon,et al.  Tumor-homing multifunctional nanoparticles for cancer theragnosis: Simultaneous diagnosis, drug delivery, and therapeutic monitoring. , 2010, Journal of Controlled Release.

[7]  V. B. Morris,et al.  Folate mediated in vitro targeting of depolymerised trimethylated chitosan having arginine functionality. , 2010, Journal of colloid and interface science.

[8]  Ick Chan Kwon,et al.  In vivo tumor diagnosis and photodynamic therapy via tumoral pH-responsive polymeric micelles. , 2010, Chemical communications.

[9]  Eung Yeop Kim,et al.  Self-confirming "AND" logic nanoparticles for fault-free MRI. , 2010, Journal of the American Chemical Society.

[10]  Forrest M Kievit,et al.  Chlorotoxin labeled magnetic nanovectors for targeted gene delivery to glioma. , 2010, ACS nano.

[11]  Qian Yang,et al.  Co-delivery of PDTC and doxorubicin by multifunctional micellar nanoparticles to achieve active targeted drug delivery and overcome multidrug resistance. , 2010, Biomaterials.

[12]  Yuquan Wei,et al.  Anti-tumor activity of N-trimethyl chitosan-encapsulated camptothecin in a mouse melanoma model , 2010, Journal of experimental & clinical cancer research : CR.

[13]  Jeong Won Lee,et al.  Targeted Gene Silencing Using RGD-Labeled Chitosan Nanoparticles , 2010, Clinical Cancer Research.

[14]  Min Liu,et al.  Glycyrrhetinic acid-modified chitosan/poly(ethylene glycol) nanoparticles for liver-targeted delivery. , 2010, Biomaterials.

[15]  L. Juillerat-Jeanneret,et al.  Chitosan-based nanogels for selective delivery of photosensitizers to macrophages and improved retention in and therapy of articular joints. , 2010, Journal of controlled release : official journal of the Controlled Release Society.

[16]  Kwangmeyung Kim,et al.  Tumor-homing glycol chitosan/polyethylenimine nanoparticles for the systemic delivery of siRNA in tumor-bearing mice. , 2010, Journal of controlled release : official journal of the Controlled Release Society.

[17]  Nicholas A Peppas,et al.  Targeted Nanodelivery of Drugs and Diagnostics. , 2010, Nano today.

[18]  Ming-Jium Shieh,et al.  Folic acid-conjugated chitosan nanoparticles enhanced protoporphyrin IX accumulation in colorectal cancer cells. , 2010, Bioconjugate chemistry.

[19]  M. Han,et al.  Tumor targeting chitosan nanoparticles for dual-modality optical/MR cancer imaging. , 2010, Bioconjugate chemistry.

[20]  Dong Wook Kim,et al.  Prostate Cancer-Targeted Imaging Using Magnetofluorescent Polymeric Nanoparticles Functionalized with Bombesin , 2010, Pharmaceutical Research.

[21]  Ralph Weissleder,et al.  Near-infrared fluorescence: application to in vivo molecular imaging. , 2010, Current opinion in chemical biology.

[22]  Klaas Nicolay,et al.  Chitosan-based systems for molecular imaging. , 2010, Advanced Drug Delivery Reviews.

[23]  Ick Chan Kwon,et al.  Targeted delivery of low molecular drugs using chitosan and its derivatives. , 2010, Advanced drug delivery reviews.

[24]  A. Louie,et al.  Multimodal magnetic-resonance/optical-imaging contrast agent sensitive to NADH. , 2009, Angewandte Chemie.

[25]  Forrest M Kievit,et al.  PEI–PEG–Chitosan‐Copolymer‐Coated Iron Oxide Nanoparticles for Safe Gene Delivery: Synthesis, Complexation, and Transfection , 2009, Advanced functional materials.

[26]  A. Trapani,et al.  The potential of glycol chitosan nanoparticles as carrier for low water soluble drugs. , 2009, International journal of pharmaceutics.

[27]  Xuan Huang,et al.  Enhanced cellular uptake of chlorine e6 mediated by stearic acid–grafted chitosan oligosaccharide micelles , 2009, Journal of drug targeting.

[28]  Jinwoo Cheon,et al.  All-in-one target-cell-specific magnetic nanoparticles for simultaneous molecular imaging and siRNA delivery. , 2009, Angewandte Chemie.

[29]  Q. Ping,et al.  PEG conjugated N-octyl-O-sulfate chitosan micelles for delivery of paclitaxel: in vitro characterization and in vivo evaluation. , 2009, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

[30]  Ick Chan Kwon,et al.  Tumor specificity and therapeutic efficacy of photosensitizer-encapsulated glycol chitosan-based nanoparticles in tumor-bearing mice. , 2009, Biomaterials.

[31]  N. Nishiyama,et al.  Design and development of dendrimer photosensitizer-incorporated polymeric micelles for enhanced photodynamic therapy. , 2009, Advanced drug delivery reviews.

[32]  J. Nah,et al.  SPION-loaded chitosan-linoleic acid nanoparticles to target hepatocytes. , 2009, International journal of pharmaceutics.

[33]  Seulki Lee,et al.  Dual-Modality Probes for in Vivo Molecular Imaging , 2009, Molecular imaging.

[34]  Shih-Chang Wang,et al.  (Carboxymethyl)chitosan-modified superparamagnetic iron oxide nanoparticles for magnetic resonance imaging of stem cells. , 2009, ACS applied materials & interfaces.

[35]  Lisa Brannon-Peppas,et al.  Active targeting schemes for nanoparticle systems in cancer therapeutics. , 2008, Advanced drug delivery reviews.

[36]  Yong Zhang,et al.  Nanoparticles in photodynamic therapy: an emerging paradigm. , 2008, Advanced drug delivery reviews.

[37]  Changren Zhou,et al.  Polysaccharides-based nanoparticles as drug delivery systems. , 2008, Advanced drug delivery reviews.

[38]  Jianping Zhou,et al.  Urocanic acid-modified chitosan-mediated p53 gene delivery inducing apoptosis of human hepatocellular carcinoma cell line HepG2 is involved in its antitumor effect in vitro and in vivo. , 2008, Biochemical and biophysical research communications.

[39]  Sen-ming Wang,et al.  [Synthesis and characterization of folic acid-conjugated chitosan nanoparticles as a tumor-targeted drug carrier]. , 2008, Nan fang yi ke da xue xue bao = Journal of Southern Medical University.

[40]  V. Torchilin Antibody-modified liposomes for cancer chemotherapy , 2008, Expert opinion on drug delivery.

[41]  I. Kwon,et al.  Tumor targetability and antitumor effect of docetaxel-loaded hydrophobically modified glycol chitosan nanoparticles. , 2008, Journal of controlled release : official journal of the Controlled Release Society.

[42]  Ick Chan Kwon,et al.  Hydrophobically modified glycol chitosan nanoparticles-encapsulated camptothecin enhance the drug stability and tumor targeting in cancer therapy. , 2008, Journal of controlled release : official journal of the Controlled Release Society.

[43]  Hossein Hosseinzadeh,et al.  Review of Pharmacological Effects of Glycyrrhiza sp. and its Bioactive Compounds , 2008, Phytotherapy research : PTR.

[44]  Kwangmeyung Kim,et al.  Antitumor efficacy of cisplatin-loaded glycol chitosan nanoparticles in tumor-bearing mice. , 2008, Journal of controlled release : official journal of the Controlled Release Society.

[45]  Hong Yuan,et al.  Folate-conjugated polymer micelles for active targeting to cancer cells: preparation, in vitro evaluation of targeting ability and cytotoxicity , 2008, Nanotechnology.

[46]  Shubiao Zhang,et al.  Cationic lipids and polymers mediated vectors for delivery of siRNA. , 2007, Journal of controlled release : official journal of the Controlled Release Society.

[47]  Ick Chan Kwon,et al.  Effect of polymer molecular weight on the tumor targeting characteristics of self-assembled glycol chitosan nanoparticles. , 2007, Journal of controlled release : official journal of the Controlled Release Society.

[48]  Sangjin Park,et al.  Thermally cross-linked superparamagnetic iron oxide nanoparticles: synthesis and application as a dual imaging probe for cancer in vivo. , 2007, Journal of the American Chemical Society.

[49]  J. Nah,et al.  Chemical modification of chitosan as a gene carrier in vitro and in vivo , 2007 .

[50]  Zhiyuan Hu,et al.  A novel PEGylation of chitosan nanoparticles for gene delivery , 2007, Biotechnology and applied biochemistry.

[51]  Shan Jiang,et al.  Quantum-dot based nanoparticles for targeted silencing of HER2/neu gene via RNA interference. , 2007, Biomaterials.

[52]  J. Kjems,et al.  The influence of polymeric properties on chitosan/siRNA nanoparticle formulation and gene silencing. , 2007, Biomaterials.

[53]  Benjamin R. Jarrett,et al.  Size-controlled synthesis of dextran sulfate coated iron oxide nanoparticles for magnetic resonance imaging , 2007, Nanotechnology.

[54]  H. Ichikawa,et al.  Gadolinium diethylenetriaminopentaacetic acid-loaded chitosan microspheres for gadolinium neutron-capture therapy. , 2006, Carbohydrate research.

[55]  Taeghwan Hyeon,et al.  Designed fabrication of multifunctional magnetic gold nanoshells and their application to magnetic resonance imaging and photothermal therapy. , 2006, Angewandte Chemie.

[56]  R. Lockey,et al.  Thiolated Chitosan/DNA Nanocomplexes Exhibit Enhanced and Sustained Gene Delivery , 2006, Pharmaceutical Research.

[57]  P. Opanasopit,et al.  Incorporation of camptothecin into N-phthaloyl chitosan-g-mPEG self-assembly micellar system. , 2006, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

[58]  Haliza Katas,et al.  Development and characterisation of chitosan nanoparticles for siRNA delivery. , 2006, Journal of controlled release : official journal of the Controlled Release Society.

[59]  Kenneth A Howard,et al.  RNA interference in vitro and in vivo using a novel chitosan/siRNA nanoparticle system. , 2006, Molecular therapy : the journal of the American Society of Gene Therapy.

[60]  J. Hwang,et al.  N-acetyl histidine-conjugated glycol chitosan self-assembled nanoparticles for intracytoplasmic delivery of drugs: endocytosis, exocytosis and drug release. , 2006, Journal of controlled release : official journal of the Controlled Release Society.

[61]  C. Cho,et al.  Mannosylated chitosan nanoparticle–based cytokine gene therapy suppressed cancer growth in BALB/c mice bearing CT-26 carcinoma cells , 2006, Molecular Cancer Therapeutics.

[62]  Ick Chan Kwon,et al.  Hydrophobically modified glycol chitosan nanoparticles as carriers for paclitaxel. , 2006, Journal of controlled release : official journal of the Controlled Release Society.

[63]  Kwangmeyung Kim,et al.  Preparation and characterization of self-assembled nanoparticles based on glycol chitosan bearing adriamycin , 2006 .

[64]  W. Tan,et al.  Multifunctional Quantum‐Dot‐Based Magnetic Chitosan Nanobeads , 2005 .

[65]  Ajay Kumar Gupta,et al.  Synthesis and surface engineering of iron oxide nanoparticles for biomedical applications. , 2005, Biomaterials.

[66]  Kwangmeyung Kim,et al.  Physicochemical characterizations of self-assembled nanoparticles of glycol chitosan-deoxycholic acid conjugates. , 2005, Biomacromolecules.

[67]  K. Leong,et al.  The effect of the degree of chitosan deacetylation on the efficiency of gene transfection. , 2004, Biomaterials.

[68]  L. Brannon-Peppas,et al.  Nanoparticle and targeted systems for cancer therapy. , 2004, Advanced drug delivery reviews.

[69]  G. V. van Dongen,et al.  Photosensitizer-antibody conjugates for detection and therapy of cancer. , 2004, Advanced drug delivery reviews.

[70]  Mark Gumbleton,et al.  Understanding endocytic pathways and intracellular trafficking: a prerequisite for effective design of advanced drug delivery systems. , 2003, Advanced drug delivery reviews.

[71]  I. Kwon,et al.  Biodistribution and anti-tumor efficacy of doxorubicin loaded glycol-chitosan nanoaggregates by EPR effect. , 2003, Journal of controlled release : official journal of the Controlled Release Society.

[72]  R. Jain,et al.  Photodynamic therapy for cancer , 2003, Nature Reviews Cancer.

[73]  R. Duncan The dawning era of polymer therapeutics , 2003, Nature Reviews Drug Discovery.

[74]  T. Allen Ligand-targeted therapeutics in anticancer therapy , 2002, Nature Reviews Cancer.

[75]  A. Maitra,et al.  Tumour targeted delivery of encapsulated dextran-doxorubicin conjugate using chitosan nanoparticles as carrier. , 2001, Journal of controlled release : official journal of the Controlled Release Society.

[76]  A. Oseroff,et al.  Mitochondria-based photodynamic anti-cancer therapy. , 2001, Advanced drug delivery reviews.

[77]  D. Sugarbaker,et al.  The α folate receptor is highly activated in malignant pleural mesothelioma , 2001 .

[78]  W. Gunning,et al.  Expression of folate receptor type alpha in relation to cell type, malignancy, and differentiation in ovary, uterus, and cervix. , 1999, Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology.

[79]  J. Ross,et al.  Differential regulation of folate receptor isoforms in normal and malignant tissues in vivo and in established cell lines. Physiologic and clinical implications , 1994, Cancer.

[80]  W. Faulk,et al.  Transferrin receptors associate with drug resistance in cancer cells. , 1993, Biochemical and biophysical research communications.

[81]  V. Stella,et al.  A kinetic and mechanistic study of the hydrolysis of camptothecin and some analogues. , 1992, Journal of pharmaceutical sciences.

[82]  H. Maeda,et al.  A new concept for macromolecular therapeutics in cancer chemotherapy: mechanism of tumoritropic accumulation of proteins and the antitumor agent smancs. , 1986, Cancer research.

[83]  S K Carter,et al.  Adriamycin. A new anticancer drug with significant clinical activity. , 1974, Annals of internal medicine.

[84]  B. Hamm,et al.  Modification of Aminosilanized Superparamagnetic Nanoparticles: Feasibility of Multimodal Detection Using 3T MRI, Small Animal PET, and Fluorescence Imaging , 2009, Molecular Imaging and Biology.

[85]  Mark Emberton,et al.  Photodynamic therapy for prostate cancer—a review of current status and future promise , 2009, Nature Clinical Practice Urology.

[86]  Jinwoo Cheon,et al.  Artificially engineered magnetic nanoparticles for ultra-sensitive molecular imaging , 2007, Nature Medicine.

[87]  Hong Liu,et al.  Enhancement of Laser Cancer Treatment by a Chitosan-derived Immunoadjuvant¶ , 2005, Photochemistry and photobiology.

[88]  K. Yarema,et al.  Targeting cancer cells with dendrimers. , 2005, Chemistry & biology.

[89]  A. Schätzlein,et al.  Anticancer Drug Delivery with Transferrin Targeted Polymeric Chitosan Vesicles , 2004, Pharmaceutical Research.

[90]  C. Bartolozzi,et al.  Abdominal MR: liver and pancreas , 1999, European Radiology.