Reappraising the cerebellum: what does the hindbrain contribute to the forebrain?

Although the cerebellum has traditionally been regarded as a motor mechanism, recent behavioral evidence indicates that the human cerebellum is involved in a wider range of functions: in learning, in planning, in judging time, in some emotional and cognitive disorders such as autism, and in some normal mental activities such as the cognitive processing of words. This evidence suggests that the traditional view of cerebellar function now needs to be reassessed and enlarged to include nonmotor as well as motor functions in the human brain. Whereas the cerebellar connections to frontal motor areas enable the cerebellum to improve motor skills, cerebellar connections to adjacent association areas of the prefrontal cortex can enable the cerebellum to improve mental skills, and cerebellar connections to Broca's area can enable the cerebellum to improve language skills.

[1]  NOUVELLE ICONOGRAPHIE DE LA SALPETRIERE , 1904 .

[2]  G. Holmes THE SYMPTOMS OF ACUTE CEREBELLAR INJURIES DUE TO GUNSHOT INJURIES , 1917 .

[3]  H. Riley,et al.  The brain from ape to man , 1928 .

[4]  G. Holmes THE CEREBELLUM OF MAN , 1939 .

[5]  R. Dow THE EVOLUTION AND ANATOMY OF THE CEREBELLUM , 1942 .

[6]  K Stern,et al.  Thalamo-frontal projection in man. , 1942, Journal of anatomy.

[7]  Bilateral frontal gyrectomy and postoperative intelligence. , 1948, Research publications - Association for Research in Nervous and Mental Disease.

[8]  A. Brodal,et al.  Neurological Anatomy in Relation to Clinical Medicine , 1950 .

[9]  G. Bonin,et al.  The isocortex of man , 1951 .

[10]  R. Dow,et al.  The Physiology and Pathology of the Cerebellum , 1958 .

[11]  W. Verhaart THE RED NUCLEUS, THE CEREBELLUM AND THE INFERIOR OLIVE IN MAN , 1962, Acta neurologica Scandinavica.

[12]  Professor Dr. John C. Eccles,et al.  The Cerebellum as a Neuronal Machine , 1967, Springer Berlin Heidelberg.

[13]  J. Massion The mammalian red nucleus. , 1967, Physiological reviews.

[14]  Some neuro-anatomical observations in cases with stereotactic lessions for the relief of parkinsonism. , 1968, Brain : a journal of neurology.

[15]  H. Stephan,et al.  QUANTITATIVE COMPARATIVE NEUROANATOMY OF PRIMATES: AN ATTEMPT AT A PHYLOGENETIC INTERPRETATION * , 1969 .

[16]  E. Perret,et al.  Functional anatomy of the dentate nucleus in the light of stereotaxic operations. , 1970, Confinia neurologica.

[17]  N. Zervas Paramedial cerebellar nuclear lesions. , 1970, Confinia neurologica.

[18]  G. C. Quarton,et al.  The Neurosciences;: Second study program , 1970 .

[19]  J. M. Van Buren,et al.  Variations and Connections of the Human Thalamus , 1972 .

[20]  A. Jolly The Evolution of Primate Behavior , 1972 .

[21]  J. Falk Physiology and Behavior. , 1973 .

[22]  G. Allen,et al.  Cerebrocerebellar communication systems. , 1974, Physiological reviews.

[23]  Dow Rs Some novel concepts of cerebellar physiology. , 1974 .

[24]  R. Passingham Changes in the size and organisation of the brain in man and his ancestors. , 1975, Brain, behavior and evolution.

[25]  G. Ojemann,et al.  ASYMMETRIC FUNCTION OF THE THALAMUS IN MAN * , 1977, Annals of the New York Academy of Sciences.

[26]  S. Dimond,et al.  Evolution and lateralization of the brain , 1977 .

[27]  M. Posner Chronometric explorations of mind , 1978 .

[28]  P. Watson Nonmotor functions of the cerebellum. , 1978, Psychological bulletin.

[29]  A. Luria Higher Cortical Functions in Man , 1980, Springer US.

[30]  J. Bloedel,et al.  Disorders of the cerebellum , 1981 .

[31]  H Goodglass,et al.  Language function, foot of the third frontal gyrus, and rolandic operculum. , 1981, Archives of neurology.

[32]  Dean Falk,et al.  Primate Brain Evolution: Methods and Concepts , 1982 .

[33]  P. Nathan,et al.  The rubrospinal and central tegmental tracts in man. , 1982, Brain : a journal of neurology.

[34]  S. Palay,et al.  The Cerebellum—New Vistas , 1982 .

[35]  G. Ojemann The intrahemispheric organization of human language, derived with electrical stimulation techniques , 1983, Trends in Neurosciences.

[36]  W. T. Thach,et al.  Distribution of cerebellar terminations and their relation to other afferent terminations in the ventral lateral thalamic region of the monkey , 1983, Brain Research Reviews.

[37]  K. Sasaki Cerebro-Cerebellar Interactions and Organization of a Fast and Stable Hand Movement: Cerebellar Participation in Voluntary Movement and Motor Learning , 1984 .

[38]  G A Ojemann,et al.  Common cortical and thalamic mechanisms for language and motor functions. , 1984, The American journal of physiology.

[39]  P. Strick,et al.  The origin of thalamic inputs to the arcuate premotor and supplementary motor areas , 1984, The Journal of neuroscience : the official journal of the Society for Neuroscience.

[40]  A. Rubens,et al.  Disturbances of long-term memory in aphasic patients. A comparison of anterior and posterior lesions. , 1984, Brain : a journal of neurology.

[41]  Masao Ito The Cerebellum And Neural Control , 1984 .

[42]  W. T. Thach,et al.  Functional mapping of the human cerebellum with positron emission tomography. , 1985, Proceedings of the National Academy of Sciences of the United States of America.

[43]  M. Botez,et al.  Reversible chronic cerebellar ataxia after phenytoin intoxication , 1985, Neurology.

[44]  M. Botez,et al.  Exploration of a hole-board matrix in nervous mutant mice , 1985, Brain Research.

[45]  M. Botez,et al.  Navigational deficits in weaver mutant mice , 1986, Brain Research.

[46]  M. Botez,et al.  Spontaneous alternation and habituation in a t-maze in nervous mutant mice. , 1986, Behavioral neuroscience.

[47]  D. Stuss,et al.  The Frontal Lobes , 1986 .

[48]  J. Houk,et al.  Functional and anatomic differentiation between parvicellular and magnocellular regions of red nucleus in the monkey , 1986, Brain Research.

[49]  A. L. Leiner,et al.  Does the cerebellum contribute to mental skills? , 1986, Behavioral neuroscience.

[50]  G. E. Alexander,et al.  Parallel organization of functionally segregated circuits linking basal ganglia and cortex. , 1986, Annual review of neuroscience.

[51]  M. Wiesendanger Initiation of Voluntary Movements and the Supplementary Motor Area , 1986 .

[52]  M. Botez,et al.  Spontaneous alternation and habituation in a T-maze in nervous mutant mice return to news gothic. , 1986 .

[53]  J. S. King,et al.  New concepts in cerebellar neurobiology , 1986 .

[54]  Richard F. Thompson The neurobiology of learning and memory. , 1986, Science.

[55]  M. Botez,et al.  Object exploration in staggerer mutant mice , 1987, Physiology & Behavior.

[56]  R. Passingham From where does the motor cortex get its instructions , 1987 .

[57]  M. Glickstein,et al.  Cerebellum and Neuronal Plasticity , 1987, NATO ASI Series.

[58]  K. Kühl,et al.  Emotion control and cerebellar atrophy in senile dementia. , 1987, Archives of gerontology and geriatrics.

[59]  M. Botez,et al.  Spontaneous alternation and habituation in Purkinje cell degeneration mutant mice , 1987, Brain Research.

[60]  C. Yeo Cerebellum and Classical Conditioning , 1987 .

[61]  J. Kihlstrom The cognitive unconscious. , 1987, Science.

[62]  V. Mountcastle,et al.  Higher functions of the brain , 1987 .

[63]  J. W. Moore,et al.  Purkinje Cell Activity and the Conditioned Nictitating Membrane Response , 1987 .

[64]  P. Goldman-Rakic Topography of cognition: parallel distributed networks in primate association cortex. , 1988, Annual review of neuroscience.

[65]  R. Dow Contribution of Electrophysiological Studies to Cerebellar Physiology , 1988, Journal of clinical neurophysiology : official publication of the American Electroencephalographic Society.

[66]  Y. Frégnac The Neural and Molecular Bases of Learning (Life Sciences Report 38 — Dahlem Konferenzen) edited by J. P. Changeux and M. Konishi, John Wiley & Sons, 1987. £55.00 (xiii + 559 pages) ISBN 0 471 91569 6 , 1988, Trends in Neurosciences.

[67]  M. Freedman,et al.  Cognitive deficits in olivopontocerebellar atrophy: Implications for the cholinergic hypothesis of Alzheimer's dementia , 1988, Annals of neurology.

[68]  A L Reiss,et al.  Preliminary communication: neuroanatomical variations of the posterior fossa in men with the fragile X (Martin-Bell) syndrome. , 1988, American journal of medical genetics.

[69]  S G Lisberger,et al.  The neural basis for learning of simple motor skills. , 1988, Science.

[70]  E. Courchesne,et al.  Hypoplasia of cerebellar vermal lobules VI and VII in autism. , 1988, The New England journal of medicine.

[71]  Richard F. Thompson The neural basis of basic associative learning of discrete behavioral responses , 1988, Trends in Neurosciences.

[72]  J. Millichap Cerebellar hypoplasia and autism. , 1989, The New England journal of medicine.

[73]  P. T. Fox,et al.  Positron emission tomographic studies of the cortical anatomy of single-word processing , 1988, Nature.

[74]  B. Rockstroh,et al.  The cerebellum contributes to mental skills. , 1989 .

[75]  P. Roland,et al.  Changes in Regional Cerebral Oxidative Metabolism Induced by Tactile Learning and Recognition in Man , 1989, The European journal of neuroscience.

[76]  M. Posner,et al.  Positron Emission Tomographic Studies of the Processing of Singe Words , 1989, Journal of Cognitive Neuroscience.

[77]  S. Keele,et al.  Timing Functions of The Cerebellum , 1989, Journal of Cognitive Neuroscience.

[78]  L. Squire,et al.  The Neuropsychology of Memory , 1990 .

[79]  J. Wind Studies in language origins , 1991 .