Chromosomally unstable mouse tumours have genomic alterations similar to diverse human cancers

[1]  M. Kelliher,et al.  The Notch1/c-Myc Pathway in T Cell Leukemia , 2007, Cell cycle.

[2]  David Botstein,et al.  Identification of alterations in DNA copy number in host stromal cells during tumor progression , 2006, Proceedings of the National Academy of Sciences.

[3]  L. Chin,et al.  Comparative Oncogenomics Identifies NEDD9 as a Melanoma Metastasis Gene , 2006, Cell.

[4]  M. Wigler,et al.  Identification and Validation of Oncogenes in Liver Cancer Using an Integrative Oncogenomic Approach , 2006, Cell.

[5]  Ralph Weissleder,et al.  Both p16(Ink4a) and the p19(Arf)-p53 pathway constrain progression of pancreatic adenocarcinoma in the mouse. , 2006, Proceedings of the National Academy of Sciences of the United States of America.

[6]  G. Tseng,et al.  Comparison of gene expression and DNA copy number changes in a murine model of lung cancer , 2006, Genes, chromosomes & cancer.

[7]  L. Chin,et al.  High-resolution genomic profiles define distinct clinico-pathogenetic subgroups of multiple myeloma patients. , 2006, Cancer cell.

[8]  L. Foroni,et al.  High incidence of Notch-1 mutations in adult patients with T-cell acute lymphoblastic leukemia , 2006, Leukemia.

[9]  F. Alt,et al.  Activating Notch1 mutations in mouse models of T-ALL. , 2005, Blood.

[10]  O. Sieber,et al.  CDC4 mutations occur in a subset of colorectal cancers but are not predicted to cause loss of function and are not associated with chromosomal instability. , 2005, Cancer research.

[11]  D. Hanahan,et al.  Incomplete inhibition of the Rb tumor suppressor pathway in the context of inactivated p53 is sufficient for pancreatic islet tumorigenesis , 2005, Oncogene.

[12]  B. Clurman,et al.  Mechanisms of Tumor Suppression by the SCFFbw7 , 2005, Cell cycle.

[13]  Andrew D. Yates,et al.  Somatic mutations of the protein kinase gene family in human lung cancer. , 2005, Cancer research.

[14]  L. Chin,et al.  High-resolution genomic profiles of human lung cancer. , 2005, Proceedings of the National Academy of Sciences of the United States of America.

[15]  D. Haber,et al.  Infrequent mutations of Archipelago (hAGO, hCDC4, Fbw7) in primary ovarian cancer. , 2005, Gynecologic oncology.

[16]  Margaret A. Strong,et al.  Telomere fusion to chromosome breaks reduces oncogenic translocations and tumour formation , 2005, Nature Cell Biology.

[17]  D. Pinkel,et al.  Array comparative genomic hybridization and its applications in cancer , 2005, Nature Genetics.

[18]  R. Hruban,et al.  Trp53R172H and KrasG12D cooperate to promote chromosomal instability and widely metastatic pancreatic ductal adenocarcinoma in mice. , 2005, Cancer cell.

[19]  J. Mesirov,et al.  An oncogenic KRAS2 expression signature identified by cross-species gene-expression analysis , 2005, Nature Genetics.

[20]  L. Strong,et al.  Gain of Function of a p53 Hot Spot Mutation in a Mouse Model of Li-Fraumeni Syndrome , 2004, Cell.

[21]  T. Jacks,et al.  Mutant p53 Gain of Function in Two Mouse Models of Li-Fraumeni Syndrome , 2004, Cell.

[22]  Allan Balmain,et al.  Fbxw7/Cdc4 is a p53-dependent, haploinsufficient tumour suppressor gene , 2004, Nature.

[23]  Andrew P. Weng,et al.  Activating Mutations of NOTCH1 in Human T Cell Acute Lymphoblastic Leukemia , 2004, Science.

[24]  A. Ferrando,et al.  Fusion of NUP214 to ABL1 on amplified episomes in T-cell acute lymphoblastic leukemia , 2004, Nature Genetics.

[25]  M. Wigler,et al.  Circular binary segmentation for the analysis of array-based DNA copy number data. , 2004, Biostatistics.

[26]  L. Pan,et al.  Disease-related potential of mutations in transcriptional cofactors CREB-binding protein and p300 in leukemias. , 2004, Cancer letters.

[27]  William R Sellers,et al.  The biology and clinical relevance of the PTEN tumor suppressor pathway. , 2004, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[28]  Andrew D. Hamilton,et al.  Akt/Protein Kinase B Signaling Inhibitor-2, a Selective Small Molecule Inhibitor of Akt Signaling with Antitumor Activity in Cancer Cells Overexpressing Akt , 2004, Cancer Research.

[29]  L. Chin,et al.  High-resolution characterization of the pancreatic adenocarcinoma genome , 2004, Proceedings of the National Academy of Sciences of the United States of America.

[30]  Carlo Rago,et al.  Inactivation of hCDC4 can cause chromosomal instability , 2004, Nature.

[31]  T. Hubbard,et al.  A census of human cancer genes , 2004, Nature Reviews Cancer.

[32]  Freddy Radtke,et al.  Notch regulation of lymphocyte development and function , 2004, Nature Immunology.

[33]  Margaret A. Strong,et al.  Short telomeres and ataxia-telangiectasia mutated deficiency cooperatively increase telomere dysfunction and suppress tumorigenesis. , 2003, Cancer research.

[34]  Wing Hung Wong,et al.  Array comparative genome hybridization for tumor classification and gene discovery in mouse models of malignant melanoma. , 2003, Cancer research.

[35]  Robert M. Bachoo,et al.  Telomere dysfunction and Atm deficiency compromises organ homeostasis and accelerates ageing , 2003, Nature.

[36]  M. Tyers,et al.  Structural Basis for Phosphodependent Substrate Selection and Orientation by the SCFCdc4 Ubiquitin Ligase , 2003, Cell.

[37]  L. Chin,et al.  Telomere dysfunction provokes regional amplification and deletion in cancer genomes. , 2002, Cancer cell.

[38]  F. Alt,et al.  Unrepaired DNA Breaks in p53-Deficient Cells Lead to Oncogenic Gene Amplification Subsequent to Translocations , 2002, Cell.

[39]  A. Nicholson,et al.  Mutations of the BRAF gene in human cancer , 2002, Nature.

[40]  R. DePinho,et al.  Telomere dysfunction and evolution of intestinal carcinoma in mice and humans , 2001, Nature Genetics.

[41]  Y. Shiloh,et al.  ATM: genome stability, neuronal development, and cancer cross paths. , 2001, Advances in cancer research.

[42]  D. Hanahan,et al.  Genome scanning with array CGH delineates regional alterations in mouse islet carcinomas , 2001, Nature Genetics.

[43]  T. Ried,et al.  Abnormal rearrangement within the α/δ T-cell receptor locus in lymphomas from Atm-deficient mice , 2000 .

[44]  Lynda Chin,et al.  Telomere dysfunction promotes non-reciprocal translocations and epithelial cancers in mice , 2000, Nature.

[45]  Lynda Chin,et al.  E.: “A Summary of , 1968 .

[46]  T. Mak,et al.  High cancer susceptibility and embryonic lethality associated with mutation of the PTEN tumor suppressor gene in mice , 1998, Current Biology.

[47]  Raphael Kopan,et al.  Notch-1 signalling requires ligand-induced proteolytic release of intracellular domain , 1998, Nature.

[48]  K. Georgopoulos,et al.  A dominant mutation in the Ikaros gene leads to rapid development of leukemia and lymphoma , 1995, Cell.

[49]  J. Sklar,et al.  TAN-1, the human homolog of the Drosophila Notch gene, is broken by chromosomal translocations in T lymphoblastic neoplasms , 1991, Cell.

[50]  G. Wahl,et al.  A central role for chromosome breakage in gene amplification, deletion formation, and amplicon integration. , 1991, Genes & development.