The Computational Simulation of the Effect of Dopamine on Short-Term and Long-Term Memory

The C-W model combines the recurrent neural network with intrinsic cellular bistability. Afterward, some research reports the effect of dopamine on working memory via replacing this intrinsic bistability with basal ganglia mechanism. In this study, our goal was to further research the effect of dopamine on short-term memory and long-term memory. Our study is based on integrating the model of striatal dopamine model and single neuron network. The results of the study found that the firing activity of the network and the value of dopamine are correlated. The higher the blood levels of dopamine, the longer the duration of network activity.

[1]  John Rinzel,et al.  An intracellular Ca2+ subsystem as a biologically plausible source of intrinsic conditional bistability in a network model of working memory , 2006, Journal of Computational Neuroscience.

[2]  J. Isaac,et al.  Evidence for silent synapses: Implications for the expression of LTP , 1995, Neuron.

[3]  I. Gozes,et al.  CREB contributes to the increased neurite outgrowth of sensory neurons induced by vasoactive intestinal polypeptide and activity-dependent neurotrophic factor , 2000, Brain Research.

[4]  Michael J. Frank,et al.  Making Working Memory Work: A Computational Model of Learning in the Prefrontal Cortex and Basal Ganglia , 2006, Neural Computation.

[5]  Xiao-Jing Wang,et al.  A Model of Visuospatial Working Memory in Prefrontal Cortex: Recurrent Network and Cellular Bistability , 1998, Journal of Computational Neuroscience.

[6]  K. Aihara,et al.  Combined effects of LTP/LTD and synaptic scaling in formation of discrete and line attractors with persistent activity from non-trivial baseline , 2012, Cognitive Neurodynamics.

[7]  Jonathan R. Whitlock,et al.  Learning Induces Long-Term Potentiation in the Hippocampus , 2006, Science.

[8]  C. Marsden,et al.  Fronto-striatal cognitive deficits at different stages of Parkinson's disease. , 1992, Brain : a journal of neurology.

[9]  Boris S. Gutkin,et al.  Dopamine modulation in the basal ganglia locks the gate to working memory , 2006, Journal of Computational Neuroscience.

[10]  Rubin Wang,et al.  The Effect of Dopamine on Working Memory , 2012, Neural Processing Letters.

[11]  E. Tarnow Short term memory bowing effect is consistent with presentation rate dependent decay , 2010, Cognitive Neurodynamics.

[12]  Jonathan D. Cohen,et al.  Dopamine and the mechanisms of cognition: Part II. D-amphetamine effects in human subjects performing a selective attention task , 1998, Biological Psychiatry.

[13]  I. Tsuda,et al.  Transitory memory retrieval in a biologically plausible neural network model , 2013, Cognitive Neurodynamics.

[14]  R. Huganir,et al.  Dopamine D1 receptors mediate CREB phosphorylation via phosphorylation of the NMDA receptor at Ser897–NR1 , 2003, Journal of neurochemistry.

[15]  Eugen Tarnow,et al.  Short term memory may be the depletion of the readily releasable pool of presynaptic neurotransmitter vesicles of a metastable long term memory trace pattern , 2009, Cognitive Neurodynamics.

[16]  E. Miyoshi,et al.  Impaired learning in a spatial working memory version and in a cued version of the water maze in rats with MPTP-induced mesencephalic dopaminergic lesions , 2002, Brain Research Bulletin.

[17]  C. Clopath Synaptic consolidation: an approach to long-term learning , 2011, Cognitive Neurodynamics.

[18]  P. Calabresi,et al.  Dopaminergic control of synaptic plasticity in the dorsal striatum , 2001, The European journal of neuroscience.

[19]  D. Schacter Searching for memory: The brain, the mind, and the past. , 1996 .