Positron emission tomography (PET) methodology for small animals and its application in radiopharmaceutical preclinical investigation.

The use and usefulness of positron emission tomography (PET) to quantify the specific and selective in vivo binding of radioligands in small laboratory animals is briefly reviewed up to the end of 1996. Emphasis is placed on practical experience with a dedicated, small diameter, tomograph (built in collaboration with CTI, Knoxville, TN), implementing conventional PET methodology.

[1]  S. Houle,et al.  In vivo evaluation of [11C]- and [18F]-labelled cocaine analogues as potential dopamine transporter ligands for positron emission tomography. , 1996, Nuclear medicine and biology.

[2]  T. Yamashita,et al.  A high resolution PET for animal studies , 1991, Conference Record of the 1991 IEEE Nuclear Science Symposium and Medical Imaging Conference.

[3]  R Lecomte,et al.  High-resolution PET imaging and quantitation of pharmaceutical biodistributions in a small animal using avalanche photodiode detectors. , 1994, Journal of nuclear medicine : official publication, Society of Nuclear Medicine.

[4]  R. Myers,et al.  Evaluation of [11C]RTI-121 as a selective radioligand for PET studies of the dopamine transporter. , 1996, Nuclear Medicine and Biology.

[5]  R. Myers.  Quantification of brain function using PET , 1996 .

[6]  D. Comar,et al.  PET for drug development and evaluation , 1995 .

[7]  D J Brooks,et al.  Comparison of Methods for Analysis of Clinical [11C]Raclopride Studies , 1996, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

[8]  Marc Laruelle,et al.  Methyl 3β‐(4‐[125I]Iodophenyl)Tropane‐2β‐Carboxylate In Vitro Binding to Dopamine and Serotonin Transporters Under “Physiological” Conditions , 1994 .

[9]  P M Bloomfield,et al.  PET scanners for small animals. , 1995, Journal of nuclear medicine : official publication, Society of Nuclear Medicine.

[10]  H N Wagner,et al.  A PET radiotracer for studying serotonin uptake sites: carbon-11-McN-5652Z. , 1993, Journal of nuclear medicine : official publication, Society of Nuclear Medicine.

[11]  Adriaan A. Lammertsma,et al.  CHAPTER 13 – Development of an On-Line Blood Detector System for PET Studies in Small Animals , 1996 .

[12]  S. Goldberg,et al.  Conditioned taste aversion and operant behavior in rats: effects of cocaine, apomorphine and some long-acting derivatives. , 1981, Journal of Pharmacology and Experimental Therapeutics.

[13]  T J Spinks,et al.  Three-dimensional performance of a small-diameter positron emission tomograph. , 1997, Physics in medicine and biology.

[14]  H. Happe,et al.  Localization and quantification of the dopamine transporter: comparison of [3H]WIN 35,428 and [125I]RTI-55 , 1995, Brain Research.

[15]  Hidenao Fukuyama,et al.  Cholinergic Projection from the Basal Forebrain and Cerebral Glucose Metabolism in Rats: A Dynamic PET Study , 1996 .

[16]  M. Bergström,et al.  Labelling of polysaccharides using [11C]cyanogen bromide. In vivo and in vitro evaluation of 11C-hyaluronan uptake kinetics. , 1995, Nuclear medicine and biology.

[17]  H. Onoe,et al.  In vitro positron emission tomography (PET): use of positron emission tracers in functional imaging in living brain slices , 1995, Neuroscience Research.

[18]  S. Cherry,et al.  A study of inter-crystal scatter in small scintillator arrays designed for high resolution PET imaging , 1995, 1995 IEEE Nuclear Science Symposium and Medical Imaging Conference Record.

[19]  L. Widén,et al.  Journal of Cerebral Blood Flow and Metabolism Rapid Feasibility Studies of Tracers for Positron Emission Tomography: High-resolution Pet in Small Animals with Kinetic Analysis , 2022 .

[20]  J S Fowler,et al.  Reproducibility of repeated measures of carbon-11-raclopride binding in the human brain. , 1993, Journal of nuclear medicine : official publication, Society of Nuclear Medicine.

[21]  Adriaan A. Lammertsma,et al.  CHAPTER 3 – Quantification of Dopamine Receptors and Transporter in Rat Striatum Using a Small Animal PET Scanner , 1996 .

[22]  A A Lammertsma,et al.  Evaluation of [O-methyl-3H]WAY-100635 as an in vivo radioligand for 5-HT1A receptors in rat brain. , 1994, European journal of pharmacology.

[23]  D. Nutt,et al.  Evaluation in rat of RS-79948-197 as a potential PET ligand for central α2-adrenoceptors , 1996 .

[24]  D J Brooks,et al.  Effect of L‐dopa and 6‐hydroxydopamine lesioning on [11C]raclopride binding in rat striatum, quantified using PET , 1995, Synapse.

[25]  C. Bench,et al.  Pharmacokinetics: Kinetic Modelling of MAO Inhibitors and D2 Antagonists , 1995 .

[26]  R. Myers,et al.  Quantitation of Carbon‐11‐labeled raclopride in rat striatum using positron emission tomography , 1992, Synapse.

[27]  Lars Farde,et al.  The advantage of using positron emission tomography in drug research , 1996, Trends in Neurosciences.

[28]  A. Lammertsma,et al.  Development of central 5-HT2A receptor radioligands for PET: comparison of [3H]RP 62203 and [3H]SR 46349B kinetics in rat brain. , 1996, Nuclear medicine and biology.

[29]  J. Baron,et al.  Specific in vivo binding in the rat brain of [18F]RP 62203: a selective 5-HT2A receptor radioligand for positron emission tomography. , 1996, Nuclear medicine and biology.

[30]  John Ashburner,et al.  Dynamic monitoring of [11C]diprenorphine in rat brain using a prototype positron imaging device , 1991, Journal of Neuroscience Methods.

[31]  W. Heiss,et al.  CHAPTER 4 – Applicability of Experimental PET in Animal Models for the Interpretation of Incidental Findings in Human Stroke , 1996 .

[32]  J S Fowler,et al.  Carbon-11-cocaine binding compared at subpharmacological and pharmacological doses: a PET study. , 1995, Journal of nuclear medicine : official publication, Society of Nuclear Medicine.

[33]  S B Dunnett,et al.  Assessment of striatal graft viability in the rat in vivo using a small diameter PET scanner. , 1995, Neuroreport.

[34]  M E Phelps,et al.  Design features and performance of a PET system for animal research. , 1992, Journal of nuclear medicine : official publication, Society of Nuclear Medicine.

[35]  M. Kuhar,et al.  In vivo labeling of cocaine binding sites on dopamine transporters with [3H]WIN 35,428. , 1991, The Journal of pharmacology and experimental therapeutics.

[36]  Adriaan A. Lammertsma,et al.  The potential of high-resolution positron emission tomography to monitor striatal dopaminergic function in rat models of disease , 1996 .

[37]  D J Brooks,et al.  GDNF protects against 6-OHDA nigrostriatal lesion: in vivo study with microdialysis and PET , 1995, Neuroreport.

[38]  R. Hichwa,et al.  Are animal scanners really necessary for PET? , 1994, Journal of nuclear medicine : official publication, Society of Nuclear Medicine.

[39]  N. Volkow,et al.  Distribution Volume Ratios without Blood Sampling from Graphical Analysis of PET Data , 1996, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

[40]  T J Spinks,et al.  The design and physical characteristics of a small animal positron emission tomograph. , 1995, Physics in medicine and biology.