Metabolomic signatures of cardiac remodelling and heart failure risk in the community

Heart failure (HF) is associated with several metabolic changes, but it is unknown whether distinct components of the circulating metabolome may be related to cardiac structure and function, and with incident HF in the community.

[1]  A. Carattoli,et al.  The interplay between , 2021 .

[2]  Erwan Donal,et al.  How to diagnose heart failure with preserved ejection fraction: the HFA-PEFF diagnostic algorithm: a consensus recommendation from the Heart Failure Association (HFA) of the European Society of Cardiology (ESC). , 2019, European heart journal.

[3]  J. Savitz.  The Kynurenine Pathway: A Finger in Every Pie , 2019, Molecular Psychiatry.

[4]  F. Parveen,et al.  An Updated Review of Lysophosphatidylcholine Metabolism in Human Diseases , 2019, International journal of molecular sciences.

[5]  Michael E. Hall,et al.  Cigarette Smoking and Incident Heart Failure: Insights From the Jackson Heart Study , 2018, Circulation.

[6]  Y. Pinto,et al.  Targeted Metabolomic Profiling of Plasma and Survival in Heart Failure Patients. , 2017, JACC. Heart failure.

[7]  Svati H. Shah,et al.  Realizing the Potential of Metabolomics in Heart Failure: Signposts on the Path to Clinical Utility. , 2017, JACC. Heart failure.

[8]  R. Baumgartner,et al.  The interplay between cytokines and the Kynurenine pathway in inflammation and atherosclerosis. , 2017, Cytokine.

[9]  S. Hazen,et al.  Gut Microbe-Generated Trimethylamine N-Oxide From Dietary Choline Is Prothrombotic in Subjects. , 2017, Circulation.

[10]  H. Bøtker,et al.  Ketone Body Infusion With 3‐Hydroxybutyrate Reduces Myocardial Glucose Uptake and Increases Blood Flow in Humans: A Positron Emission Tomography Study , 2017, Journal of the American Heart Association.

[11]  Jacob P. Kelly,et al.  Metabolomic Profiling Identifies Novel Circulating Biomarkers of Mitochondrial Dysfunction Differentially Elevated in Heart Failure With Preserved Versus Reduced Ejection Fraction: Evidence for Shared Metabolic Impairments in Clinical Heart Failure , 2016, Journal of the American Heart Association.

[12]  D. Kass,et al.  Phenotype-Specific Treatment of Heart Failure With Preserved Ejection Fraction: A Multiorgan Roadmap , 2016, Circulation.

[13]  R. Tomasin,et al.  Nutritional leucine supplementation attenuates cardiac failure in tumour‐bearing cachectic animals , 2016, Journal of cachexia, sarcopenia and muscle.

[14]  K. Margulies,et al.  Evidence for Intramyocardial Disruption of Lipid Metabolism and Increased Myocardial Ketone Utilization in Advanced Human Heart Failure , 2016, Circulation.

[15]  Ming-Huei Chen,et al.  Metabolomic Profiles of Body Mass Index in the Framingham Heart Study Reveal Distinct Cardiometabolic Phenotypes , 2016, PloS one.

[16]  S. Hazen,et al.  Choline Diet and Its Gut Microbe–Derived Metabolite, Trimethylamine N-Oxide, Exacerbate Pressure Overload–Induced Heart Failure , 2016, Circulation. Heart failure.

[17]  S. Anker,et al.  Impact of Plasma Kynurenine Level on Functional Capacity and Outcome in Heart Failure　- Results From Studies Investigating Co-morbidities Aggravating Heart Failure (SICA-HF). , 2016, Circulation journal : official journal of the Japanese Circulation Society.

[18]  Y. Fujiwara,et al.  Kynurenine causes vasodilation and hypotension induced by activation of KCNQ-encoded voltage-dependent K(+) channels. , 2015, Journal of pharmacological sciences.

[19]  T. Spector,et al.  Amino Acid Intakes Are Inversely Associated with Arterial Stiffness and Central Blood Pressure in Women12 , 2015, The Journal of nutrition.

[20]  S. Hazen,et al.  Intestinal microbiota-dependent phosphatidylcholine metabolites, diastolic dysfunction, and adverse clinical outcomes in chronic systolic heart failure. , 2015, Journal of cardiac failure.

[21]  R. Vasan,et al.  Epidemiology of heart failure with preserved ejection fraction. , 2014, Heart failure clinics.

[22]  G. Liebisch,et al.  Application of stable isotopes to investigate the metabolism of fatty acids, glycerophospholipid and sphingolipid species. , 2014, Progress in lipid research.

[23]  J. DiNicolantonio,et al.  Effects of thiamine on cardiac function in patients with systolic heart failure: systematic review and metaanalysis of randomized, double-blind, placebo-controlled trials. , 2013, The Ochsner journal.

[24]  R. Vasan,et al.  2-Aminoadipic acid is a biomarker for diabetes risk. , 2013, The Journal of clinical investigation.

[25]  M. Laakso,et al.  Association of Ketone Body Levels With Hyperglycemia and Type 2 Diabetes in 9,398 Finnish Men , 2013, Diabetes.

[26]  P. Ueland,et al.  Urinary excretion of kynurenine and tryptophan, cardiovascular events, and mortality after elective coronary angiography. , 2013, European heart journal.

[27]  E. Boerwinkle,et al.  Associations between metabolomic compounds and incident heart failure among African Americans: the ARIC Study. , 2013, American journal of epidemiology.

[28]  R. Vasan,et al.  A combined epidemiologic and metabolomic approach improves CKD prediction. , 2013, Journal of the American Society of Nephrology : JASN.

[29]  Rajeev Gupta,et al.  Smokeless tobacco and cardiovascular disease in low and middle income countries. , 2013, Indian heart journal.

[30]  S. Hazen,et al.  Intestinal microbial metabolism of phosphatidylcholine and cardiovascular risk. , 2013, The New England journal of medicine.

[31]  O. Franco,et al.  Resting Heart Rate and the Risk of Heart Failure in Healthy Adults: The Rotterdam Study , 2013, Circulation. Heart failure.

[32]  M. Koenig,et al.  Mitochondrial cardiomyopathy: pathophysiology, diagnosis, and management. , 2013, Texas Heart Institute journal.

[33]  K. Michaëlsson,et al.  Smokeless tobacco (snus) and risk of heart failure: results from two Swedish cohorts , 2012, European journal of preventive cardiology.

[34]  K. Bibbins-Domingo,et al.  Cigarette smoking exposure and heart failure risk in older adults: the Health, Aging, and Body Composition Study. , 2012, American heart journal.

[35]  James D. Thomas,et al.  Pulmonary hypertension associated with advanced systolic heart failure: dysregulated arginine metabolism and importance of compensatory dimethylarginine dimethylaminohydrolase-1. , 2012, Journal of the American College of Cardiology.

[36]  V. Gebski,et al.  Tryptophan metabolism to kynurenine is a potential novel contributor to hypotension in human sepsis* , 2011, Critical care medicine.

[37]  S. Carr,et al.  Lipid profiling identifies a triacylglycerol signature of insulin resistance and improves diabetes prediction in humans. , 2011, The Journal of clinical investigation.

[38]  V. Mootha,et al.  Metabolite profiles and the risk of developing diabetes , 2011, Nature Medicine.

[39]  Brian J. Bennett,et al.  Gut flora metabolism of phosphatidylcholine promotes cardiovascular disease , 2011, Nature.

[40]  Jane Chen,et al.  Altered systemic ketone body metabolism in advanced heart failure. , 2011, Texas Heart Institute journal.

[41]  P. D. De Deyn,et al.  The Role of Tryptophan Catabolism along the Kynurenine Pathway in Acute Ischemic Stroke , 2010, Neurochemical Research.

[42]  E. Benjamin,et al.  Thyroid function and left ventricular structure and function in the Framingham Heart Study. , 2010, Thyroid : official journal of the American Thyroid Association.

[43]  J. Stasch,et al.  Kynurenine is an endothelium-derived relaxing factor produced during inflammation , 2010, Nature Medicine.

[44]  P. Weeke,et al.  Diabetes is associated with impaired myocardial performance in patients without significant coronary artery disease , 2010, Cardiovascular diabetology.

[45]  D. Levy,et al.  Relations of Lipid Concentrations to Heart Failure Incidence: The Framingham Heart Study , 2009, Circulation.

[46]  K. Straif,et al.  Use of smokeless tobacco and risk of myocardial infarction and stroke: systematic review with meta-analysis , 2009, BMJ : British Medical Journal.

[47]  D. Levy,et al.  Resistin, adiponectin, and risk of heart failure the Framingham offspring study. , 2009, Journal of the American College of Cardiology.

[48]  S. Mariotti,et al.  Cardiac effects of L-thyroxine administration in borderline hypothyroidism. , 2008, International journal of cardiology.

[49]  Qiong Yang,et al.  The Third Generation Cohort of the National Heart, Lung, and Blood Institute's Framingham Heart Study: design, recruitment, and initial examination. , 2007, American journal of epidemiology.

[50]  S. Yusuf,et al.  Glucose Levels Predict Hospitalization for Congestive Heart Failure in Patients at High Cardiovascular Risk , 2007, Circulation.

[51]  E. Ingelsson,et al.  Novel metabolic risk factors for heart failure. , 2005, Journal of the American College of Cardiology.

[52]  R. Ransohoff,et al.  Lysophosphatidylcholine regulates human microvascular endothelial cell expression of chemokines. , 2003, Journal of molecular and cellular cardiology.

[53]  Heinrich Taegtmeyer,et al.  Obesity and the risk of heart failure. , 2002, The New England journal of medicine.

[54]  L. Elinder,et al.  Lysophosphatidylcholine is involved in the antigenicity of oxidized LDL. , 1998, Arteriosclerosis, thrombosis, and vascular biology.

[55]  D. Levy,et al.  Left ventricular dilatation and the risk of congestive heart failure in people without myocardial infarction. , 1997, The New England journal of medicine.

[56]  J. Lommi,et al.  Blood ketone bodies in congestive heart failure. , 1996, Journal of the American College of Cardiology.

[57]  N Reichek,et al.  Echocardiographic Determination of Left Ventricular Mass in Man: Anatomic Validation of the Method , 1977, Circulation.

[58]  W. Kannel,et al.  The Framingham Offspring Study. Design and preliminary data. , 1975, Preventive medicine.