Application of phosphoinositide-binding domains for the detection and quantification of specific phosphoinositides.

[1]  Shiro Suetsugu,et al.  Rac-WAVE2 signaling is involved in the invasive and metastatic phenotypes of murine melanoma cells , 2005, Oncogene.

[2]  G. Yancopoulos,et al.  Absence of the lipid phosphatase SHIP2 confers resistance to dietary obesity , 2005, Nature Medicine.

[3]  Wayne A. Phillips,et al.  Mutation of the PIK3CA Gene in Ovarian and Breast Cancer , 2004, Cancer Research.

[4]  P. Janmey,et al.  Cytoskeletal regulation: rich in lipids , 2004, Nature Reviews Molecular Cell Biology.

[5]  Hiroyuki Konishi,et al.  The PIK3CA gene is mutated with high frequency in human breast cancers , 2004, Cancer biology & therapy.

[6]  D. Alessi,et al.  FAPPs control Golgi-to-cell-surface membrane traffic by binding to ARF and PtdIns(4)P , 2004, Nature Cell Biology.

[7]  D. Yamazaki,et al.  PtdIns(3,4,5)P3 binding is necessary for WAVE2-induced formation of lamellipodia , 2004, Nature Cell Biology.

[8]  Francisca Vazquez,et al.  Novel Mechanism of PTEN Regulation by Its Phosphatidylinositol 4,5-Bisphosphate Binding Motif Is Critical for Chemotaxis* , 2004, Journal of Biological Chemistry.

[9]  T. Takenawa,et al.  Myotubularin Regulates the Function of the Late Endosome through the GRAM Domain-Phosphatidylinositol 3,5-Bisphosphate Interaction* , 2004, Journal of Biological Chemistry.

[10]  J. A. Radding,et al.  Cloning, expression, purification, and characterization of the human Class Ia phosphoinositide 3-kinase isoforms. , 2004, Protein expression and purification.

[11]  M. Czech Dynamics of phosphoinositides in membrane retrieval and insertion. , 2003, Annual review of physiology.

[12]  N. Ban,et al.  Membrane association of myotubularin-related protein 2 is mediated by a pleckstrin homology-GRAM domain and a coiled-coil dimerization module , 2003, Proceedings of the National Academy of Sciences of the United States of America.

[13]  B. Payrastre,et al.  Phosphoinositide signaling disorders in human diseases , 2003, FEBS letters.

[14]  M. Lemmon,et al.  Phosphoinositide Recognition Domains , 2003, Traffic.

[15]  K. Kunii,et al.  Type II Phosphatidylinositol 4-Kinase β Is a Cytosolic and Peripheral Membrane Protein That Is Recruited to the Plasma Membrane and Activated by Rac-GTP* , 2002, The Journal of Biological Chemistry.

[16]  T. Takenawa,et al.  Phosphoinositide-binding domains: Functional units for temporal and spatial regulation of intracellular signalling. , 2002, Cellular signalling.

[17]  C. Downes,et al.  PTEN: The down side of PI 3-kinase signalling. , 2002, Cellular signalling.

[18]  Simon Andrews,et al.  The PX domain: a new phosphoinositide-binding module. , 2002, Journal of cell science.

[19]  T. Takenawa,et al.  Phosphoinositides, key molecules for regulation of actin cytoskeletal organization and membrane traffic from the plasma membrane. , 2001, Biochimica et biophysica acta.

[20]  P. Cullen,et al.  Modular phosphoinositide-binding domains – their role in signalling and membrane trafficking , 2001, Current Biology.

[21]  M. Zvelebil,et al.  Activation Loop Sequences Confer Substrate Specificity to Phosphoinositide 3-Kinase α (PI3Kα) , 2001, The Journal of Biological Chemistry.

[22]  H. Stenmark,et al.  Cellular functions of phosphatidylinositol 3-phosphate and FYVE domain proteins. , 2001, The Biochemical journal.

[23]  T. Kigawa,et al.  Role of the ENTH domain in phosphatidylinositol-4,5-bisphosphate binding and endocytosis. , 2001, Science.

[24]  P. Bork,et al.  GRAM, a novel domain in glucosyltransferases, myotubularins and other putative membrane-associated proteins. , 2000, Trends in biochemical sciences.

[25]  Roger L. Williams,et al.  Structural determinants of phosphoinositide 3-kinase inhibition by wortmannin, LY294002, quercetin, myricetin, and staurosporine. , 2000, Molecular cell.

[26]  S. Dowler,et al.  Identification of pleckstrin-homology-domain-containing proteins with novel phosphoinositide-binding specificities. , 2000, The Biochemical journal.

[27]  Toshio Hakoshima,et al.  Structural basis of the membrane‐targeting and unmasking mechanisms of the radixin FERM domain , 2000, The EMBO journal.

[28]  M. Lindsay,et al.  Localization of phosphatidylinositol 3‐phosphate in yeast and mammalian cells , 2000, The EMBO journal.

[29]  J. Dixon,et al.  A sensitive assay for phosphoinositide phosphatases. , 2000, Analytical biochemistry.

[30]  Alexander G. Gray,et al.  The pleckstrin homology domains of protein kinase B and GRP1 (general receptor for phosphoinositides-1) are sensitive and selective probes for the cellular detection of phosphatidylinositol 3,4-bisphosphate and/or phosphatidylinositol 3,4,5-trisphosphate in vivo. , 1999, The Biochemical journal.

[31]  Tomohiko Maehama,et al.  Crystal Structure of the PTEN Tumor Suppressor Implications for Its Phosphoinositide Phosphatase Activity and Membrane Association , 1999, Cell.

[32]  L. Cantley,et al.  New insights into tumor suppression: PTEN suppresses tumor formation by restraining the phosphoinositide 3-kinase/AKT pathway. , 1999, Proceedings of the National Academy of Sciences of the United States of America.

[33]  Péter Várnai,et al.  Visualization of Phosphoinositides That Bind Pleckstrin Homology Domains: Calcium- and Agonist-induced Dynamic Changes and Relationship to Myo-[3H]inositol-labeled Phosphoinositide Pools , 1998, The Journal of cell biology.

[34]  L. Tamm,et al.  Formation of supported planar bilayers by fusion of vesicles to supported phospholipid monolayers. , 1992, Biochimica et biophysica acta.

[35]  I. Fidler,et al.  Selection of successive tumour lines for metastasis. , 1973, Nature: New biology.