Chapter 42 Sex differences in COVID-19 susceptibility – Reductionistic and holistic perspectives

[1]  B. Pflugeisen,et al.  Gender Discrepancies in SARS-CoV-2 Pandemic Related Beliefs, Attitudes, and Practices , 2021, Frontiers in Public Health.

[2]  M. Peluso,et al.  Markers of Immune Activation and Inflammation in Individuals With Postacute Sequelae of Severe Acute Respiratory Syndrome Coronavirus 2 Infection. , 2021, The Journal of infectious diseases.

[3]  A. Masci,et al.  CIDO ontology updates and secondary analysis of host responses to COVID-19 infection based on ImmPort reports and literature , 2021, Journal of Biomedical Semantics.

[4]  I. Koralnik,et al.  T cell responses to SARS-CoV-2 in people with and without neurologic symptoms of long COVID , 2021, medRxiv.

[5]  F. Cheng,et al.  Multimodal single-cell omics analysis identifies epithelium–immune cell interactions and immune vulnerability associated with sex differences in COVID-19 , 2021, Signal Transduction and Targeted Therapy.

[6]  M. Cameron,et al.  Sex and age bias viral burden and interferon responses during SARS-CoV-2 infection in ferrets , 2021, Scientific Reports.

[7]  S. Klein,et al.  Sex Differences in Lung Imaging and SARS-CoV-2 Antibody Responses in a COVID-19 Golden Syrian Hamster Model , 2021, mBio.

[8]  M. Safford,et al.  Sex-Related Differences in Clinical Presentation and Risk Factors for Mortality in Patients Hospitalized With Coronavirus Disease 2019 in New York City , 2021, Open forum infectious diseases.

[9]  M. C. Muenker,et al.  Kynurenic acid may underlie sex-specific immune responses to COVID-19 , 2021, Science Signaling.

[10]  D. Leach,et al.  The antiandrogen enzalutamide downregulates TMPRSS2 and reduces cellular entry of SARS-CoV-2 in human lung cells , 2021, Nature Communications.

[11]  C. Cordon-Cardo,et al.  Analysis of sex-specific risk factors and clinical outcomes in COVID-19 , 2021, Communications Medicine.

[12]  E. Sierra-Diaz,et al.  The role of estradiol in the immune response against COVID-19 , 2021, Hormones.

[13]  Jeffrey M. McManus,et al.  Androgen regulation of pulmonary AR, TMPRSS2 and ACE2 with implications for sex-discordant COVID-19 outcomes , 2021, Scientific Reports.

[14]  M. Singer,et al.  Sex differences in immunological responses to COVID-19: a cross-sectional analysis of a single-centre cohort , 2021, British Journal of Anaesthesia.

[15]  I. Jurisica,et al.  The relationship between cytokine and neutrophil gene network distinguishes SARS-CoV-2–infected patients by sex and age , 2021, JCI insight.

[16]  Zengrui Wu,et al.  Association of Circulating Sex Hormones With Inflammation and Disease Severity in Patients With COVID-19 , 2021, JAMA network open.

[17]  I. Bassett,et al.  Sex differences in inflammatory markers in patients hospitalized with COVID-19 infection: Insights from the MGH COVID-19 patient registry , 2021, PloS one.

[18]  A. Traish.  Sex steroids and COVID-19 mortality in women , 2021, Trends in Endocrinology & Metabolism.

[19]  S. Klein,et al.  Sex differences in lung imaging and SARS-CoV-2 antibody responses in a COVID-19 golden Syrian hamster model , 2021, bioRxiv.

[20]  M. Barish,et al.  Sex-Based Differences in COVID-19 Outcomes. , 2021, Journal of women's health.

[21]  E. Morris,et al.  COVID-19 in Women's health: Epidemiology , 2021, Best Practice & Research Clinical Obstetrics & Gynaecology.

[22]  Huachen Zhu,et al.  Gender associates with both susceptibility to infection and pathogenesis of SARS-CoV-2 in Syrian hamster , 2021, Signal Transduction and Targeted Therapy.

[23]  David A. Drew,et al.  Attributes and predictors of long COVID , 2021, Nature Medicine.

[24]  J. Pawlotsky,et al.  Viral genomic, metagenomic and human transcriptomic characterization and prediction of the clinical forms of COVID-19 , 2021, PLoS pathogens.

[25]  H. Peckham,et al.  Male sex identified by global COVID-19 meta-analysis as a risk factor for death and ITU admission , 2020, Nature Communications.

[26]  A. Casadevall,et al.  Cytokine and Chemokine Levels in Coronavirus Disease 2019 Convalescent Plasma , 2020, Open forum infectious diseases.

[27]  Noel S. Weiss,et al.  COVID-19 mortality risk for older men and women , 2020, BMC Public Health.

[28]  Hongyu Zhao,et al.  Androgen Signaling Regulates SARS-CoV-2 Receptor Levels and Is Associated with Severe COVID-19 Symptoms in Men , 2020, Cell Stem Cell.

[29]  Benjamin S. Glicksberg,et al.  Sex differences in viral entry protein expression, host responses to SARS-CoV-2, and in vitro responses to sex steroid hormone treatment in COVID-19. , 2020, Research square.

[30]  A. Prats-Uribe,et al.  Filling the gaps in the characterization of the clinical management of COVID-19: 30-day hospital admission and fatality rates in a cohort of 118 150 cases diagnosed in outpatient settings in Spain , 2020, International journal of epidemiology.

[31]  S. Subbian,et al.  Critical Determinants of Cytokine Storm and Type I Interferon Response in COVID-19 Pathogenesis , 2020, Clinical microbiology reviews.

[32]  R. Schooley,et al.  COVID-19—Lessons Learned and Questions Remaining , 2020, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

[33]  K. Peter,et al.  Higher mortality of COVID-19 in males: sex differences in immune response and cardiovascular comorbidities , 2020, Cardiovascular research.

[34]  A. Pradhan,et al.  Sex differences in severity and mortality from COVID-19: are males more vulnerable? , 2020, Biology of sex differences.

[35]  Vaishali R. Moulton,et al.  What’s Sex Got to Do With COVID-19? Gender-Based Differences in the Host Immune Response to Coronaviruses , 2020, Frontiers in Immunology.

[36]  S. Farhadian,et al.  Sex differences in immune responses that underlie COVID-19 disease outcomes , 2020, Nature.

[37]  R. Preissner,et al.  Oestrogen-mediated upregulation of the Mas receptor contributes to sex differences in acute lung injury and lung vascular barrier regulation , 2020, European Respiratory Journal.

[38]  E. Vivarelli,et al.  A gendered magnifying glass on COVID-19 , 2020, Clinical and Molecular Allergy.

[39]  R. Blumenthal,et al.  Men and COVID-19: A Biopsychosocial Approach to Understanding Sex Differences in Mortality and Recommendations for Practice and Policy Interventions , 2020, Preventing chronic disease.

[40]  Arthur S Slutsky,et al.  Molecular mechanisms of sex bias differences in COVID-19 mortality , 2020, Critical Care.

[41]  A. Casadevall,et al.  Pathogenesis of COVID-19 from the Perspective of the Damage-Response Framework , 2020, mBio.

[42]  Harnish Mukesh Naik,et al.  Sex, age, and hospitalization drive antibody responses in a COVID-19 convalescent plasma donor population , 2020, medRxiv.

[43]  B. Zhu,et al.  Serum Cytokine and Chemokine Profile in Relation to the Severity of Coronavirus Disease 2019 in China , 2020, The Journal of infectious diseases.

[44]  J. Atkinson,et al.  The complement system in COVID-19: friend and foe? , 2020, JCI insight.

[45]  A. Agarwal,et al.  Prognostic factors for severity and mortality in patients infected with COVID-19: A systematic review , 2020, PloS one.

[46]  G. Bwire.  Coronavirus: Why Men are More Vulnerable to Covid-19 Than Women? , 2020, SN Comprehensive Clinical Medicine.

[47]  Xiujun Li,et al.  Age-dependent gender differences of COVID-19 in mainland China: comparative study , 2020, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

[48]  N. Jewell,et al.  Incidence, clinical outcomes, and transmission dynamics of severe coronavirus disease 2019 in California and Washington: prospective cohort study , 2020, BMJ.

[49]  Y. Prakash,et al.  Estrogen regulates the expression of SARS-CoV-2 receptor ACE2 in differentiated airway epithelial cells , 2020, American journal of physiology. Lung cellular and molecular physiology.

[50]  M. Rugge,et al.  Androgen-deprivation therapies for prostate cancer and risk of infection by SARS-CoV-2: a population-based study (N = 4532) , 2020, Annals of Oncology.

[51]  Lynnette Brammer,et al.  Hospitalization Rates and Characteristics of Patients Hospitalized with Laboratory-Confirmed Coronavirus Disease 2019 — COVID-NET, 14 States, March 1–30, 2020 , 2020, MMWR. Morbidity and mortality weekly report.

[52]  Y. Ho,et al.  SARS-CoV-2: A Storm is Raging. , 2020, The Journal of clinical investigation.

[53]  Robyn M. Kaake,et al.  A systems approach to infectious disease , 2020, Nature Reviews Genetics.

[54]  Konrad J. Karczewski,et al.  Integrative omics for health and disease , 2018, Nature Reviews Genetics.

[55]  P. T. Ten Eyck,et al.  Sex-Based Differences in Susceptibility to Severe Acute Respiratory Syndrome Coronavirus Infection , 2017, The Journal of Immunology.

[56]  S. Klein,et al.  Sex differences in immune responses , 2016, Nature Reviews Immunology.

[57]  A. Casadevall,et al.  Reductionistic and Holistic Science , 2011, Infection and Immunity.

[58]  D. Weatherall.  Molecules and man , 1987, Nature.

[59]  J. Kulkarni,et al.  Sex Differences and COVID-19. , 2021, Advances in experimental medicine and biology.

[60]  H. Hackstein,et al.  TLR7 ligands induce higher IFN-alpha production in females. , 2006, Journal of immunology.

[61]  Marc H V Van Regenmortel,et al.  Reductionism and complexity in molecular biology. Scientists now have the tools to unravel biological and overcome the limitations of reductionism. , 2004, EMBO reports.

[62]  P. Nurse.  Reductionism and explanation in cell biology. , 1998, Novartis Foundation symposium.

[63]  Stuart A. Kauffman,et al.  The origins of order , 1993 .