The Synthesis of Isomeric Dithymidyl-phosphorus(V)-meso-tetraphenylporphyrins

The synthesis of three novel axial dinucleosides was successfully accomplished. The compounds are 5″-O, 5″-O-dithymidylphosphorus(V)-meso-tetraphenylporphyrin, 5″-O, 3″-O-dithymi-dylphosphorus(V)-meso-tetraphenylporphyrin, and 3″-O, 3″-O-dithymidylphosphorus(V)tetraphenylporo-phyrin. These compounds could provide a lead toward the synthesis of an oligo-porphyrinyl DNA analogue that represents a system containing phosphorus(V)porphine units axially connected through the 5″-O-thymidine-3″-O bridges.