Donor variation in stored platelets: Higher metabolic rates of platelets are associated with mean platelet volume, activation and donor health

Platelets (PLTs) differ in glycolytic activity, resulting in rapid acidification of ‘poor’ storing PLT concentrates (PCs) in plasma, or depletion of glucose when stored in PLT additive solution (PAS). We aimed to understand why PLT glycolysis rates vary between donors and how this affects storage performance.

[1]  G. Tomac,et al.  Platelet transfusion practice and related transfusion reactions in a large teaching hospital. , 2021, Transfusion clinique et biologique : journal de la Societe francaise de transfusion sanguine.

[2]  Mikko Arvas,et al.  Low ferritin levels appear to be associated with worsened health in male repeat blood donors , 2021, Vox sanguinis.

[3]  K. Zacharowski,et al.  The effect of the interruption of agitation, temporary cooling, and pneumatic tube transportation on platelet quality during storage for transfusion , 2020, Transfusion.

[4]  H. Kamel,et al.  Characterization of health issues in young first‐time blood donors , 2020, Vox sanguinis.

[5]  U. Völker,et al.  Role of Platelet Size Revisited—Function and Protein Composition of Large and Small Platelets , 2019, Thrombosis and Haemostasis.

[6]  A. Verhoeven,et al.  Platelet storage properties are associated with donor age: in vitro quality of platelets from young donors and older donors with and without Type 2 diabetes , 2018, Vox sanguinis.

[7]  R. Sturmey,et al.  Glucose metabolism and metabolic flexibility in blood platelets , 2018, Journal of thrombosis and haemostasis : JTH.

[8]  A. Greinacher,et al.  Toward the Relevance of Platelet Subpopulations for Transfusion Medicine , 2018, Front. Med..

[9]  A. Verhoeven,et al.  Platelet storage performance is consistent by donor: a pilot study comparing “good” and “poor” storing platelets , 2017, Transfusion.

[10]  R. Cardigan,et al.  Quality control of apheresis platelets: a multicentre study to evaluate factors that can influence pH measurement , 2017, Vox sanguinis.

[11]  A. Eder,et al.  The effect of iron balance on platelet counts in blood donors , 2017, Transfusion.

[12]  Chris I. Jones Platelet function and ageing , 2016, Mammalian Genome.

[13]  J. Attia,et al.  Prognostic effect of mean platelet volume in patients with coronary artery disease , 2015, Thrombosis and Haemostasis.

[14]  M. Gelb,et al.  Platelets release mitochondria serving as substrate for bactericidal group IIA-secreted phospholipase A2 to promote inflammation. , 2014, Blood.

[15]  D. Korte,et al.  Determination of thromboelastographic responsiveness in stored single‐donor platelet concentrates , 2014, Transfusion.

[16]  R. Eferl,et al.  Iron deficiency alters megakaryopoiesis and platelet phenotype independent of thrombopoietin , 2014, American journal of hematology.

[17]  John Welsh,et al.  Increased platelet storage time is associated with mitochondrial dysfunction and impaired platelet function. , 2013, The Journal of surgical research.

[18]  J. Cancelas,et al.  In vitro and in vivo quality of leukoreduced apheresis platelets stored in a new platelet additive solution , 2013, Transfusion.

[19]  Vineta Fellman,et al.  Mitochondrial respiration in human viable platelets--methodology and influence of gender, age and storage. , 2013, Mitochondrion.

[20]  D. de Korte,et al.  Active cooling of whole blood to room temperature improves blood component quality , 2011, Transfusion.

[21]  D. Korte,et al.  In vitro comparison of platelet storage in plasma and in four platelet additive solutions, and the effect of pathogen reduction: a proposal for an in vitro rating system , 2010, Vox sanguinis.

[22]  Y. Abe,et al.  A simple technique to determine thrombopoiesis level using immature platelet fraction (IPF). , 2006, Thrombosis research.

[23]  E. Coban,et al.  The mean platelet volume in patients with obesity , 2005, International journal of clinical practice.

[24]  E. Maltezos,et al.  Mean platelet volume in patients with type 2 diabetes mellitus , 2004, Platelets.

[25]  S. Karpatkin,et al.  Heterogeneity of human platelets. V. Differences in glycolytic and related enzymes with possible relation to platelet age. , 1972, The Journal of clinical investigation.

[26]  S. Karpatkin Heterogeneity of human platelets. I. Metabolic and kinetic evidence suggestive of young and old platelets. , 1969, The Journal of clinical investigation.