H3K27 Methylation: A Focal Point of Epigenetic Deregulation in Cancer.
暂无分享,去创建一个
J. Licht | W. Miller | T. Ezponda | D. Dupéré-Richer | J. Nichol | Jonathan D. Licht | Wilson H. Miller | Jessica N. Nichol | Daphné Dupéré-Richer | Teresa Ezponda | Daphné Dupéré-Richer | J. N. Nichol | Jessica N. Nichol
[1] T. Perkins,et al. UTX inhibition as selective epigenetic therapy against TAL1-driven T-cell acute lymphoblastic leukemia , 2016, Genes & development.
[2] R. Gibbs,et al. Genomic analyses identify molecular subtypes of pancreatic cancer , 2016, Nature.
[3] T. Sixma,et al. BAP1/ASXL1 recruitment and activation for H2A deubiquitination , 2016, Nature Communications.
[4] Q. Li,et al. Epigenetic regulation of gene expression by Ikaros, HDAC1 and Casein Kinase II in leukemia , 2015, Leukemia.
[5] A. Italiano,et al. Phase 1 Study of Tazemetostat (EPZ-6438), an Inhibitor of Enhancer of Zeste-Homolog 2 (EZH2): Preliminary Safety and Activity in Relapsed or Refractory Non-Hodgkin Lymphoma (NHL) Patients , 2015 .
[6] Thomas P. Howard,et al. SWI/SNF-mutant cancers depend on catalytic and non-catalytic activity of EZH2 , 2015, Nature Medicine.
[7] S. Armstrong,et al. The PZP Domain of AF10 Senses Unmodified H3K27 to Regulate DOT1L-Mediated Methylation of H3K79. , 2015, Molecular cell.
[8] Simon Hallam,et al. High Throughput Sequencing Analysis of the Immunoglobulin Heavy Chain Gene from Flow-Sorted B Cell Sub-Populations Define the Dynamics of Follicular Lymphoma Clonal Evolution , 2015, PloS one.
[9] S. Armstrong,et al. Loss of BAP1 function leads to EZH2-dependent transformation , 2015, Nature Medicine.
[10] G. Kong,et al. UTX inhibits EMT‐induced breast CSC properties by epigenetic repression of EMT genes in cooperation with LSD1 and HDAC1 , 2015, EMBO reports.
[11] H. Lähdesmäki,et al. Cancer-associated ASXL1 mutations may act as gain-of-function mutations of the ASXL1–BAP1 complex , 2015, Nature Communications.
[12] Joshua M. Korn,et al. Development of secondary mutations in wild-type and mutant EZH2 alleles cooperates to confer resistance to EZH2 inhibitors , 2015, Oncogene.
[13] J. Kench,et al. Whole genomes redefine the mutational landscape of pancreatic cancer , 2015, Nature.
[14] V. Stojanoff,et al. Small-molecule modulators of methyl-lysine binding for the CBX7 chromodomain. , 2015, Chemistry & biology.
[15] Y. Xiong,et al. WT1 recruits TET2 to regulate its target gene expression and suppress leukemia cell proliferation. , 2015, Molecular cell.
[16] Benjamin G. Bitler,et al. Synthetic lethality by targeting EZH2 methyltransferase activity in ARID1A-mutated cancers , 2015, Nature Medicine.
[17] Zheng Zhou,et al. Strong expression of EZH2 and accumulation of trimethylated H3K27 in diffuse large B-cell lymphoma independent of cell of origin and EZH2 codon 641 mutation , 2015, Leukemia & lymphoma.
[18] M. Follettie,et al. Epigenetic reprogramming by tumor-derived EZH2 gain-of-function mutations promotes aggressive 3D cell morphologies and enhances melanoma tumor growth , 2015, Oncotarget.
[19] R. Dummer,et al. The epigenetic modifier EZH2 controls melanoma growth and metastasis through silencing of distinct tumour suppressors , 2015, Nature Communications.
[20] A. Feinberg,et al. Mutant WT1 is associated with DNA hypermethylation of PRC2 targets in AML and responds to EZH2 inhibition. , 2015, Blood.
[21] C. Allis,et al. Use of human embryonic stem cells to model pediatric gliomas with H3.3K27M histone mutation , 2014, Science.
[22] S. Armstrong,et al. AF10 regulates progressive H3K79 methylation and HOX gene expression in diverse AML subtypes. , 2014, Cancer cell.
[23] B. Garcia,et al. Selective inhibition of EZH2 and EZH1 enzymatic activity by a small molecule suppresses MLL-rearranged leukemia. , 2014, Blood.
[24] G. Tonon,et al. Loss of the Histone Demethylase UTX Contributes to Multiple Myeloma and Sensitizes Cells to EZH2 Inhibitors , 2014 .
[25] E. Pronier,et al. DNA hydroxymethylation profiling reveals that WT1 mutations result in loss of TET2 function in acute myeloid leukemia. , 2014, Cell reports.
[26] C. Plass,et al. PRC2 loss amplifies Ras signaling in cancer , 2014, Nature Genetics.
[27] Claude Gazin,et al. TRIM37 is a new histone H2A ubiquitin ligase and breast cancer oncoprotein , 2014, Nature.
[28] L. Qin,et al. PRC2 is recurrently inactivated through EED or SUZ12 loss in malignant peripheral nerve sheath tumors , 2014, Nature Genetics.
[29] Zhiming Cai,et al. Concurrent Alterations in TERT, KDM6A, and the BRCA Pathway in Bladder Cancer , 2014, Clinical Cancer Research.
[30] C. James,et al. Pharmacologic inhibition of histone demethylation as a therapy for pediatric brainstem glioma , 2014, Nature Medicine.
[31] Eugenia G. Giannopoulou,et al. Histone Methyltransferase MMSET/NSD2 Alters EZH2 Binding and Reprograms the Myeloma Epigenome through Global and Focal Changes in H3K36 and H3K27 Methylation , 2014, PLoS genetics.
[32] R. Johnstone,et al. Histone deacetylases and their inhibitors in cancer, neurological diseases and immune disorders , 2014, Nature Reviews Drug Discovery.
[33] Kyle V. Butler,et al. Discovery of a Selective, Substrate-Competitive Inhibitor of the Lysine Methyltransferase SETD8 , 2014, Journal of medicinal chemistry.
[34] R. Jaenisch,et al. Contrasting roles for histone 3 lysine 27 demethylases in acute lymphoblastic leukemia , 2014, Nature.
[35] A. Iwama,et al. Ezh2 loss promotes development of myelodysplastic syndrome but attenuates its predisposition to leukaemic transformation , 2014, Nature Communications.
[36] N. Brockdorff,et al. Variant PRC1 Complex-Dependent H2A Ubiquitylation Drives PRC2 Recruitment and Polycomb Domain Formation , 2014, Cell.
[37] A. Fusco,et al. CBX7 Modulates the Expression of Genes Critical for Cancer Progression , 2014, PloS one.
[38] M. Vermeulen,et al. Histone H2A monoubiquitination promotes histone H3 methylation in Polycomb repression , 2014, Nature Structural &Molecular Biology.
[39] Liliana Goumnerova,et al. Recurrent somatic mutations in ACVR1 in pediatric midline high-grade astrocytoma , 2014, Nature Genetics.
[40] Min Gyu Lee,et al. UTX and MLL4 coordinately regulate transcriptional programs for cell proliferation and invasiveness in breast cancer cells. , 2014, Cancer research.
[41] Michael Brudno,et al. Genomic analysis of diffuse intrinsic pontine gliomas identifies three molecular subgroups and recurrent activating ACVR1 mutations , 2014, Nature Genetics.
[42] Tim J. Wigle,et al. Selective Inhibition of EZH2 by EPZ-6438 Leads to Potent Antitumor Activity in EZH2-Mutant Non-Hodgkin Lymphoma , 2014, Molecular Cancer Therapeutics.
[43] A. Singh,et al. EZH2: Not EZHY (Easy) to Deal , 2014, Molecular Cancer Research.
[44] Fang Fang,et al. The H3K27me3 demethylase UTX is a gender-specific tumor suppressor in T-cell acute lymphoblastic leukemia. , 2014, Blood.
[45] S. Gabriel,et al. Discovery and saturation analysis of cancer genes across 21 tumor types , 2014, Nature.
[46] David T. W. Jones,et al. Reduced H3K27me3 and DNA hypomethylation are major drivers of gene expression in K27M mutant pediatric high-grade gliomas. , 2013, Cancer cell.
[47] H. Aburatani,et al. Myelodysplastic syndromes are induced by histone methylation–altering ASXL1 mutations. , 2013, The Journal of clinical investigation.
[48] M. Stratton,et al. Distinct H3F3A and H3F3B driver mutations define chondroblastoma and giant cell tumor of bone , 2013, Nature Genetics.
[49] Manel Juan,et al. Landscape of somatic mutations and clonal evolution in mantle cell lymphoma , 2013, Proceedings of the National Academy of Sciences.
[50] Huanming Yang,et al. Whole-genome and whole-exome sequencing of bladder cancer identifies frequent alterations in genes involved in sister chromatid cohesion and segregation , 2013, Nature Genetics.
[51] Jacob D. Jaffe,et al. Global chromatin profiling reveals NSD2 mutations in pediatric acute lymphoblastic leukemia , 2013, Nature Genetics.
[52] M. Ramalho-Santos,et al. Histone variant H3.3 maintains a decondensed chromatin state essential for mouse preimplantation development , 2013, Development.
[53] S. Orkin,et al. Targeted Disruption of the EZH2/EED Complex Inhibits EZH2-dependent Cancer , 2013, Nature chemical biology.
[54] X. Hua,et al. Menin: a scaffold protein that controls gene expression and cell signaling. , 2013, Trends in biochemical sciences.
[55] D. Nam,et al. Phosphorylation of EZH2 activates STAT3 signaling via STAT3 methylation and promotes tumorigenicity of glioblastoma stem-like cells. , 2013, Cancer cell.
[56] A. Jankowska,et al. Multiple mechanisms deregulate EZH2 and histone H3 lysine 27 epigenetic changes in myeloid malignancies , 2013, Leukemia.
[57] Qiang Yu,et al. EZH2 overexpression in natural killer /T-cell lymphoma confers growth advantage independently of histone methyltransferase activity , 2013 .
[58] Benjamin J. Raphael,et al. The Mutational Landscape of Adenoid Cystic Carcinoma , 2013, Nature Genetics.
[59] B. Garcia,et al. Inhibition of PRC2 Activity by a Gain-of-Function H3 Mutation Found in Pediatric Glioblastoma , 2013, Science.
[60] O. Elemento,et al. EZH2 is required for germinal center formation and somatic EZH2 mutations promote lymphoid transformation. , 2013, Cancer cell.
[61] Sabine Mueller,et al. The histone H3.3K27M mutation in pediatric glioma reprograms H3K27 methylation and gene expression. , 2013, Genes & development.
[62] P. Cairns,et al. Aberrant promoter hypermethylation of PBRM1, BAP1, SETD2, KDM6A and other chromatin-modifying genes is absent or rare in clear cell RCC , 2013, Epigenetics.
[63] Tim J. Wigle,et al. Durable tumor regression in genetically altered malignant rhabdoid tumors by inhibition of methyltransferase EZH2 , 2013, Proceedings of the National Academy of Sciences.
[64] A. Sun,et al. EZH2 Mutations Are Related to Low Blast Percentage in Bone Marrow and -7/del(7q) in De Novo Acute Myeloid Leukemia , 2013, PloS one.
[65] P. Knoepfler,et al. Endogenous mammalian histone H3.3 exhibits chromatin-related functions during development , 2013, Epigenetics & Chromatin.
[66] Benjamin E. Gross,et al. Integrative Analysis of Complex Cancer Genomics and Clinical Profiles Using the cBioPortal , 2013, Science Signaling.
[67] O. Elemento,et al. MMSET dysregulates gene expression in myeloma through global and focal changes in H3K36 and H3K27 methylation , 2013, Epigenetics & Chromatin.
[68] K. Helin,et al. Polycomb Cbx family members mediate the balance between haematopoietic stem cell self-renewal and differentiation , 2013, Nature Cell Biology.
[69] S. Lowe,et al. The Polycomb complex PRC2 supports aberrant self-renewal in a mouse model of MLL-AF9;NrasG12D acute myeloid leukemia , 2013, Oncogene.
[70] M. Esteller,et al. Genetic syndromes caused by mutations in epigenetic genes , 2013, Human Genetics.
[71] Zhaohui S. Qin,et al. Characterization of the EZH2-MMSET histone methyltransferase regulatory axis in cancer. , 2013, Molecular cell.
[72] M. Loda,et al. EZH2 Oncogenic Activity in Castration-Resistant Prostate Cancer Cells Is Polycomb-Independent , 2012, Science.
[73] T. Veenstra,et al. Histone Demethylase Jumonji D3 (JMJD3) as a Tumor Suppressor by Regulating p53 Protein Nuclear Stabilization , 2012, PloS one.
[74] S. Ogawa,et al. EED mutants impair polycomb repressive complex 2 in myelodysplastic syndrome and related neoplasms , 2012, Leukemia.
[75] A. Emili,et al. Discovery of a chemical probe for the L3MBTL3 methyl-lysine reader domain , 2012, Nature chemical biology.
[76] M. Hazar-Rethinam,et al. Dysregulation of the Repressive H3K27 Trimethylation Mark in Head and Neck Squamous Cell Carcinoma Contributes to Dysregulated Squamous Differentiation , 2012, Clinical Cancer Research.
[77] David T. W. Jones,et al. Hotspot mutations in H3F3A and IDH1 define distinct epigenetic and biological subgroups of glioblastoma. , 2012, Cancer cell.
[78] Lei Jin,et al. A687V EZH2 is a gain‐of‐function mutation found in lymphoma patients , 2012, FEBS letters.
[79] Somasekar Seshagiri,et al. Loss of the Tumor Suppressor BAP1 Causes Myeloid Transformation , 2012, Science.
[80] Stefano Monti,et al. Integrative analysis reveals an outcome-associated and targetable pattern of p53 and cell cycle deregulation in diffuse large B cell lymphoma. , 2012, Cancer cell.
[81] X. Zhou,et al. Dense Chromatin Activates Polycomb Repressive Complex 2 to Regulate H3 Lysine 27 Methylation , 2012, Science.
[82] Iannis Aifantis,et al. ASXL1 mutations promote myeloid transformation through loss of PRC2-mediated gene repression. , 2012, Cancer cell.
[83] Jonathan D. Licht,et al. Total kinetic analysis reveals how combinatorial methylation patterns are established on lysines 27 and 36 of histone H3 , 2012, Proceedings of the National Academy of Sciences.
[84] S. Sugano,et al. Ezh2 augments leukemogenicity by reinforcing differentiation blockage in acute myeloid leukemia. , 2012, Blood.
[85] Christopher J. Schofield,et al. A selective jumonji H3K27 demethylase inhibitor modulates the proinflammatory macrophage response , 2012, Nature.
[86] A. Sivachenko,et al. A Landscape of Driver Mutations in Melanoma , 2012, Cell.
[87] N. Kelleher,et al. The Histone Methyltransferase MMSET/WHSC1 Activates TWIST1 to Promote an Epithelial-Mesenchymal Transition and Invasive Properties of Prostate Cancer , 2012, Oncogene.
[88] David T. W. Jones,et al. K27M mutation in histone H3.3 defines clinically and biologically distinct subgroups of pediatric diffuse intrinsic pontine gliomas , 2012, Acta Neuropathologica.
[89] Christoph Bock,et al. Sequential ChIP-bisulfite sequencing enables direct genome-scale investigation of chromatin and DNA methylation cross-talk , 2012, Genome research.
[90] M. Robinson,et al. Bisulfite sequencing of chromatin immunoprecipitated DNA (BisChIP-seq) directly informs methylation status of histone-modified DNA , 2012, Genome research.
[91] N. Grishin,et al. BAP1 loss defines a new class of renal cell carcinoma , 2012, Nature Genetics.
[92] Benjamin E. Gross,et al. The cBio cancer genomics portal: an open platform for exploring multidimensional cancer genomics data. , 2012, Cancer discovery.
[93] P. Scacheri,et al. Histone Demethylase UTX and Chromatin Remodeler BRM Bind Directly to CBP and Modulate Acetylation of Histone H3 Lysine 27 , 2012, Molecular and Cellular Biology.
[94] Jindan Yu,et al. Interrogating genomic and epigenomic data to understand prostate cancer. , 2012, Biochimica et biophysica acta.
[95] G. Boucher,et al. A key role for EZH2 and associated genes in mouse and human adult T-cell acute leukemia. , 2012, Genes & development.
[96] Shadan Ali,et al. Loss of Let-7 Up-Regulates EZH2 in Prostate Cancer Consistent with the Acquisition of Cancer Stem Cell Signatures That Are Attenuated by BR-DIM , 2012, PloS one.
[97] S. Armstrong,et al. Polycomb repressive complex 2 is required for MLL-AF9 leukemia , 2012, Proceedings of the National Academy of Sciences.
[98] Yong Jiang,et al. Mutation of A677 in histone methyltransferase EZH2 in human B-cell lymphoma promotes hypertrimethylation of histone H3 on lysine 27 (H3K27) , 2012, Proceedings of the National Academy of Sciences.
[99] David T. W. Jones,et al. Driver mutations in histone H3.3 and chromatin remodelling genes in paediatric glioblastoma , 2012, Nature.
[100] S. Scherer,et al. Clonal Selection Drives Genetic Divergence of Metastatic Medulloblastoma , 2012, Nature.
[101] Li Ding,et al. Somatic Histone H3 Alterations in Paediatric Diffuse Intrinsic Pontine Gliomas and Non-Brainstem Glioblastomas , 2012, Nature Genetics.
[102] Kiran C. Bobba,et al. The genetic basis of early T-cell precursor acute lymphoblastic leukaemia , 2012, Nature.
[103] Giacomo Cavalli,et al. Trithorax group proteins: switching genes on and keeping them active , 2011, Nature Reviews Molecular Cell Biology.
[104] B. Garcia,et al. NSD2 links dimethylation of histone H3 at lysine 36 to oncogenic programming. , 2011, Molecular cell.
[105] Jing Liang,et al. Corepressor Protein CDYL Functions as a Molecular Bridge between Polycomb Repressor Complex 2 and Repressive Chromatin Mark Trimethylated Histone Lysine 27* , 2011, The Journal of Biological Chemistry.
[106] Kwok-Kin Wong,et al. Exploiting cancer cell vulnerabilities to develop a combination therapy for ras-driven tumors. , 2011, Cancer cell.
[107] Huanming Yang,et al. Frequent mutations of chromatin remodeling genes in transitional cell carcinoma of the bladder , 2011, Nature Genetics.
[108] N. Cox,et al. Germline BAP1 mutations predispose to malignant mesothelioma , 2011, Nature Genetics.
[109] D. Birnbaum,et al. Mutations and deletions of the SUZ12 polycomb gene in myeloproliferative neoplasms , 2011, Blood cancer journal.
[110] Jeannie T. Lee,et al. YY1 Tethers Xist RNA to the Inactive X Nucleation Center , 2011, Cell.
[111] A. McKenna,et al. The Mutational Landscape of Head and Neck Squamous Cell Carcinoma , 2011, Science.
[112] Xiao Li,et al. Overexpression of the EZH2, RING1 and BMI1 genes is common in myelodysplastic syndromes: relation to adverse epigenetic alteration and poor prognostic scoring , 2011, Annals of Hematology.
[113] P. Angrand,et al. Functional characterization of human Polycomb-like 3 isoforms identifies them as components of distinct EZH2 protein complexes. , 2011, The Biochemical journal.
[114] M. Salto‐Tellez,et al. Activated oncogenic pathways and therapeutic targets in extranodal nasal‐type NK/T cell lymphoma revealed by gene expression profiling , 2011, The Journal of pathology.
[115] Ryan D. Morin,et al. Somatic mutations at EZH2 Y641 act dominantly through a mechanism of selectively altered PRC2 catalytic activity, to increase H3K27 trimethylation. , 2011, Blood.
[116] Paul Tempst,et al. PRC2 Complexes with JARID2, MTF2, and esPRC2p48 in ES Cells to Modulate ES Cell Pluripotency and Somatic Cell Reprograming , 2011, Stem cells.
[117] G. Almouzni,et al. The double face of the histone variant H3.3 , 2011, Cell Research.
[118] B. Zhu,et al. H3K36 Methylation Antagonizes PRC2-mediated H3K27 Methylation* , 2011, The Journal of Biological Chemistry.
[119] L. Staudt,et al. The MMSET histone methyl transferase switches global histone methylation and alters gene expression in t(4;14) multiple myeloma cells. , 2011, Blood.
[120] Toshiro K. Ohsumi,et al. Genome-wide identification of polycomb-associated RNAs by RIP-seq. , 2010, Molecular cell.
[121] Raul Rabadan,et al. Inactivating mutations of acetyltransferase genes in B-cell lymphoma , 2010, Nature.
[122] A. Bowcock,et al. Frequent Mutation of BAP1 in Metastasizing Uveal Melanomas , 2010, Science.
[123] R. Copeland,et al. Coordinated activities of wild-type plus mutant EZH2 drive tumor-associated hypertrimethylation of lysine 27 on histone H3 (H3K27) in human B-cell lymphomas , 2010, Proceedings of the National Academy of Sciences.
[124] B. Bernstein,et al. Mammalian Polycomb-Like Pcl2/Mtf2 Is a Novel Regulatory Component of PRC2 That Can Differentially Modulate Polycomb Activity both at the Hox Gene Cluster and at Cdkn2a Genes , 2010, Molecular and Cellular Biology.
[125] Chao Xu,et al. Binding of different histone marks differentially regulates the activity and specificity of polycomb repressive complex 2 (PRC2) , 2010, Proceedings of the National Academy of Sciences.
[126] Scott L Pomeroy,et al. Epigenetic antagonism between polycomb and SWI/SNF complexes during oncogenic transformation. , 2010, Cancer cell.
[127] E. Kremmer,et al. Identification and characterization of two novel primate-specific histone H3 variants, H3.X and H3.Y , 2010, The Journal of cell biology.
[128] R. Kuiper,et al. Somatic mutations of the histone methyltransferase gene EZH2 in myelodysplastic syndromes , 2010, Nature Genetics.
[129] H. Drexler,et al. Inactivating mutations of the histone methyltransferase gene EZH2 in myeloid disorders , 2010, Nature Genetics.
[130] C. Allis,et al. Daxx is an H3.3-specific histone chaperone and cooperates with ATRX in replication-independent chromatin assembly at telomeres , 2010, Proceedings of the National Academy of Sciences.
[131] E. Delbarre,et al. Chromatin Environment of Histone Variant H3.3 Revealed by Quantitative Imaging and Genome-scale Chromatin and DNA Immunoprecipitation , 2010, Molecular biology of the cell.
[132] G. Kristiansen,et al. Class I histone deacetylases 1, 2 and 3 are highly expressed in classical Hodgkin's lymphoma , 2010, Expert opinion on therapeutic targets.
[133] A. Fusco,et al. Loss of the CBX7 protein expression correlates with a more aggressive phenotype in pancreatic cancer. , 2010, European journal of cancer.
[134] Kristian Helin,et al. Characterization of an antagonistic switch between histone H3 lysine 27 methylation and acetylation in the transcriptional regulation of Polycomb group target genes , 2010, Nucleic acids research.
[135] Juri Rappsilber,et al. JARID2 regulates binding of the Polycomb repressive complex 2 to target genes in ES cells , 2010, Nature.
[136] S. Rafii,et al. Distinct Factors Control Histone Variant H3.3 Localization at Specific Genomic Regions , 2010, Cell.
[137] Nevan J Krogan,et al. Polycomb-like 2 associates with PRC2 and regulates transcriptional networks during mouse embryonic stem cell self-renewal and differentiation. , 2010, Cell stem cell.
[138] Gang Li,et al. Jarid2 and PRC2, partners in regulating gene expression. , 2010, Genes & development.
[139] Ryan D. Morin,et al. Somatic mutation of EZH2 (Y641) in Follicular and Diffuse Large B-cell Lymphomas of Germinal Center Origin , 2010, Nature Genetics.
[140] Arend Sidow,et al. Jarid2/Jumonji Coordinates Control of PRC2 Enzymatic Activity and Target Gene Occupancy in Pluripotent Cells , 2009, Cell.
[141] D. Reinberg,et al. Role of the polycomb protein EED in the propagation of repressive histone marks , 2009, Nature.
[142] P. Scacheri,et al. CBP-mediated acetylation of histone H3 lysine 27 antagonizes Drosophila Polycomb silencing , 2009, Development.
[143] Y. Furukawa,et al. Expression Levels of Histone Deacetylases Determine the Cell Fate of Hematopoietic Progenitors* , 2009, The Journal of Biological Chemistry.
[144] Vincenza Leone,et al. Chromobox protein homologue 7 protein, with decreased expression in human carcinomas, positively regulates E-cadherin expression by interacting with the histone deacetylase 2 protein. , 2009, Cancer research.
[145] Dinshaw J. Patel,et al. Haematopoietic malignancies caused by dysregulation of a chromatin-binding PHD finger , 2009, Nature.
[146] G. Neri,et al. Faculty Opinions recommendation of Somatic mutations of the histone H3K27 demethylase gene UTX in human cancer. , 2009 .
[147] G. Morgan,et al. MMSET deregulation affects cell cycle progression and adhesion regulons in t(4;14) myeloma plasma cells , 2009, Haematologica.
[148] S. Varambally,et al. Genomic Loss of microRNA-101 Leads to Overexpression of Histone Methyltransferase EZH2 in Cancer , 2008, Science.
[149] S. Dhanasekaran,et al. Repression of E-cadherin by the polycomb group protein EZH2 in cancer , 2008, Oncogene.
[150] S. Elledge,et al. CDYL bridges REST and histone methyltransferases for gene repression and suppression of cellular transformation. , 2008, Molecular cell.
[151] D. Reinberg,et al. Ezh1 and Ezh2 maintain repressive chromatin through different mechanisms. , 2008, Molecular cell.
[152] I. Christensen,et al. Prognostic significance of the therapeutic targets histone deacetylase 1, 2, 6 and acetylated histone H4 in cutaneous T-cell lymphoma , 2008, Histopathology.
[153] P. Hokland,et al. Gene expression profiling of Polycomb, Hox and Meis genes in patients with acute myeloid leukaemia , 2008, European journal of haematology.
[154] Y. Nakanuma,et al. Over‐expression of polycomb group protein EZH2 relates to decreased expression of p16INK4a in cholangiocarcinogenesis in hepatolithiasis , 2008, The Journal of pathology.
[155] Terry Magnuson,et al. Polycomb Repressive Complex 2 Is Dispensable for Maintenance of Embryonic Stem Cell Pluripotency , 2008, Stem cells.
[156] C. Verrijzer,et al. SWI/SNF Mediates Polycomb Eviction and Epigenetic Reprogramming of the INK4b-ARF-INK4a Locus , 2008, Molecular and Cellular Biology.
[157] R. Arceci,et al. The multiple myeloma associated MMSET gene contributes to cellular adhesion, clonogenic growth, and tumorigenicity. , 2008, Blood.
[158] T. Veenstra,et al. Identification of JmjC domain-containing UTX and JMJD3 as histone H3 lysine 27 demethylases , 2007, Proceedings of the National Academy of Sciences.
[159] Min Gyu Lee,et al. Demethylation of H3K27 Regulates Polycomb Recruitment and H2A Ubiquitination , 2007, Science.
[160] J. Chai,et al. Structural basis of EZH2 recognition by EED. , 2007, Structure.
[161] I. Issaeva,et al. UTX and JMJD3 are histone H3K27 demethylases involved in HOX gene regulation and development , 2007, Nature.
[162] H. Stunnenberg,et al. Pcl-PRC2 is needed to generate high levels of H3-K27 trimethylation at Polycomb target genes , 2007, The EMBO journal.
[163] G. Dressler,et al. PTIP Associates with MLL3- and MLL4-containing Histone H3 Lysine 4 Methyltransferase Complex*♦ , 2007, Journal of Biological Chemistry.
[164] G. Wang,et al. NUP98–NSD1 links H3K36 methylation to Hox-A gene activation and leukaemogenesis , 2007, Nature Cell Biology.
[165] Qiang Yu,et al. Pharmacologic disruption of Polycomb-repressive complex 2-mediated gene repression selectively induces apoptosis in cancer cells. , 2007, Genes & development.
[166] Kristian Helin,et al. The Polycomb Group Protein Suz12 Is Required for Embryonic Stem Cell Differentiation , 2007, Molecular and Cellular Biology.
[167] T. Kouzarides. Chromatin Modifications and Their Function , 2007, Cell.
[168] C. Croce,et al. Knockdown of ALR (MLL2) Reveals ALR Target Genes and Leads to Alterations in Cell Adhesion and Growth , 2006, Molecular and Cellular Biology.
[169] A. Chinnaiyan,et al. Histone deacetylase inhibitors deplete enhancer of zeste 2 and associated polycomb repressive complex 2 proteins in human acute leukemia cells , 2006, Molecular Cancer Therapeutics.
[170] Tapio Visakorpi,et al. The gene for polycomb group protein enhancer of zeste homolog 2 (EZH2) is amplified in late‐stage prostate cancer , 2006, Genes, chromosomes & cancer.
[171] L. Bystrykh,et al. The Polycomb group gene Ezh2 prevents hematopoietic stem cell exhaustion. , 2006, Blood.
[172] O. Halvorsen,et al. EZH2 expression is associated with high proliferation rate and aggressive tumor subgroups in cutaneous melanoma and cancers of the endometrium, prostate, and breast. , 2006, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.
[173] Hiroko Yamashita,et al. Quantitation of HDAC1 mRNA Expression in Invasive Carcinoma of the Breast* , 2005, Breast Cancer Research and Treatment.
[174] Matthew Meyerson,et al. The Menin Tumor Suppressor Protein Is an Essential Oncogenic Cofactor for MLL-Associated Leukemogenesis , 2005, Cell.
[175] J. Keats,et al. Overexpression of transcripts originating from the MMSET locus characterizes all t(4;14)(p16;q32)-positive multiple myeloma patients. , 2005, Blood.
[176] Kristian Helin,et al. Suz12 is essential for mouse development and for EZH2 histone methyltransferase activity , 2004, The EMBO journal.
[177] Yi Zhang,et al. The functions of E(Z)/EZH2-mediated methylation of lysine 27 in histone H3. , 2004, Current opinion in genetics & development.
[178] Kristian Helin,et al. EZH2 is downstream of the pRB‐E2F pathway, essential for proliferation and amplified in cancer , 2003, The EMBO journal.
[179] Debashis Ghosh,et al. EZH2 is a marker of aggressive breast cancer and promotes neoplastic transformation of breast epithelial cells , 2003, Proceedings of the National Academy of Sciences of the United States of America.
[180] Tony Reiman,et al. In multiple myeloma, t(4;14)(p16;q32) is an adverse prognostic factor irrespective of FGFR3 expression. , 2003, Blood.
[181] D. Reinberg,et al. Histone methyltransferase activity associated with a human multiprotein complex containing the Enhancer of Zeste protein. , 2002, Genes & development.
[182] Brigitte Wild,et al. Histone Methyltransferase Activity of a Drosophila Polycomb Group Repressor Complex , 2002, Cell.
[183] V. Pirrotta,et al. Drosophila Enhancer of Zeste/ESC Complexes Have a Histone H3 Methyltransferase Activity that Marks Chromosomal Polycomb Sites , 2002, Cell.
[184] S. Dhanasekaran,et al. The polycomb group protein EZH2 is involved in progression of prostate cancer , 2002, Nature.
[185] Hengbin Wang,et al. Role of Histone H3 Lysine 27 Methylation in Polycomb-Group Silencing , 2002, Science.
[186] S. Henikoff,et al. The histone variant H3.3 marks active chromatin by replication-independent nucleosome assembly. , 2002, Molecular cell.
[187] M. Lipinski,et al. HIRA is critical for a nucleosome assembly pathway independent of DNA synthesis. , 2002, Molecular cell.
[188] E. Lander,et al. Gene expression signatures define novel oncogenic pathways in T cell acute lymphoblastic leukemia. , 2002, Cancer cell.
[189] H. Kwon,et al. Expression Profile of Histone Deacetylase 1 in Gastric Cancer Tissues , 2001, Japanese journal of cancer research : Gann.
[190] A. Otte,et al. Transcriptional repression mediated by the human polycomb-group protein EED involves histone deacetylation , 1999, Nature Genetics.
[191] K. Bomsztyk,et al. Point Mutations in the WD40 Domain of Eed Block Its Interaction with Ezh2 , 1998, Molecular and Cellular Biology.
[192] O. Witt,et al. Testis-specific expression of a novel human H3 histone gene. , 1996, Experimental cell research.
[193] R. I. Glazer,et al. 3-Deazaneplanocin: a new and potent inhibitor of S-adenosylhomocysteine hydrolase and its effects on human promyelocytic leukemia cell line HL-60. , 1986, Biochemical and biophysical research communications.
[194] E. Rego,et al. Overexpression of EZH2 associates with a poor prognosis in chronic lymphocytic leukemia. , 2015, Blood cells, molecules & diseases.
[195] N. Kelleher,et al. Point mutation E1099K in MMSET/NSD2 enhances its methyltranferase activity and leads to altered global chromatin methylation in lymphoid malignancies , 2014, Leukemia.
[196] J. Khan,et al. EZH2 Mediates epigenetic silencing of neuroblastoma suppressor genes CASZ1, CLU, RUNX3, and NGFR. , 2012, Cancer research.
[197] K. Döhner,et al. Inactivation of polycomb repressive complex 2 components in myeloproliferative and myelodysplastic/myeloproliferative neoplasms. , 2012, Blood.
[198] A. Fusco,et al. CBX7 is a tumor suppressor in mice and humans. , 2012, The Journal of clinical investigation.
[199] Hana Kim,et al. AEBP2 as a potential targeting protein for Polycomb Repression Complex PRC2 , 2009 .
[200] Peter A. Jones,et al. The putative tumor suppressor microRNA-101 modulates the cancer epigenome by repressing the polycomb group protein EZH2. , 2009, Cancer research.
[201] L. J,et al. Rearrangement of the MLL Gene Confers a Poor Prognosis in Childhood Acute Lymphoblastic Leukemia , Regardless of Presenting Age , 2002 .