Cellular target engagement: a new paradigm in drug discovery.
暂无分享,去创建一个
[1] D. M. Molina,et al. Determining direct binders of the Androgen Receptor using a high-throughput Cellular Thermal Shift Assay , 2018, Scientific Reports.
[2] Daniel Martinez Molina,et al. The Cellular Thermal Shift Assay: A Novel Biophysical Assay for In Situ Drug Target Engagement and Mechanistic Biomarker Studies. , 2016, Annual review of pharmacology and toxicology.
[3] Thomas Lundbäck,et al. CETSA: a target engagement assay with potential to transform drug discovery. , 2015, Future Medicinal Chemistry.
[4] W. Childers,et al. Discovery of innovative therapeutics: today's realities and tomorrow's vision. 2. Pharma's challenges and their commitment to innovation. , 2014, Journal of medicinal chemistry.
[5] Michael Williams,et al. Replicated, replicable and relevant-target engagement and pharmacological experimentation in the 21st century. , 2014, Biochemical pharmacology.
[6] P. Nordlund,et al. Monitoring Drug Target Engagement in Cells and Tissues Using the Cellular Thermal Shift Assay , 2013, Science.
[7] A. Magurran,et al. Asymmetry in pay-off predicts how familiar individuals respond to one another , 2013, Biology Letters.
[8] B. Cravatt,et al. Determining target engagement in living systems. , 2013, Nature chemical biology.
[9] S. Ramaswamy,et al. Systematic identification of genomic markers of drug sensitivity in cancer cells , 2012, Nature.
[10] P. Workman,et al. Discovery of small molecule cancer drugs: Successes, challenges and opportunities , 2012, Molecular oncology.
[11] Paul D. Leeson,et al. The influence of the 'organizational factor' on compound quality in drug discovery , 2011, Nature Reviews Drug Discovery.
[12] M. Bunnage. Getting pharmaceutical R&D back on target. , 2011, Nature chemical biology.
[13] Ian H Gilbert,et al. Target Validation: Linking Target and Chemical Properties to Desired Product Profile , 2011, Current topics in medicinal chemistry.
[14] John P. Overington,et al. Probing the links between in vitro potency, ADMET and physicochemical parameters , 2011, Nature Reviews Drug Discovery.
[15] Stephen V Frye,et al. The art of the chemical probe. , 2010, Nature chemical biology.
[16] Brian K Shoichet,et al. A detergent-based assay for the detection of promiscuous inhibitors , 2006, Nature Protocols.
[17] Daumantas Matulis,et al. Thermodynamic stability of carbonic anhydrase: measurements of binding affinity and stoichiometry using ThermoFluor. , 2005, Biochemistry.
[18] W. Patrick Walters,et al. A guide to drug discovery: Designing screens: how to make your hits a hit , 2003, Nature Reviews Drug Discovery.
[19] J F Brandts,et al. Study of strong to ultratight protein interactions using differential scanning calorimetry. , 1990, Biochemistry.
[20] D. Crothers. Statistical thermodynamics of nucleic acid melting transitions with coupled binding equilibria , 1971, Biopolymers.