Cell polarity proteins and cancer.

[1]  D. Tuveson,et al.  SCRIB expression is deregulated in human prostate cancer, and its deficiency in mice promotes prostate neoplasia. , 2011, The Journal of clinical investigation.

[2]  P. Laprise,et al.  Crumbs controls epithelial integrity by inhibiting Rac1 and PI3K , 2011, Journal of Cell Science.

[3]  K. Basler,et al.  Loss of PI3K blocks cell-cycle progression in a Drosophila tumor model , 2011, Oncogene.

[4]  Krishna R. Kalari,et al.  Protein kinase Cι expression and oncogenic signaling mechanisms in cancer , 2011, Journal of cellular physiology.

[5]  D. Hanahan,et al.  Hallmarks of Cancer: The Next Generation , 2011, Cell.

[6]  F. Kern,et al.  Ras and Raf pathways in epidermis development and carcinogenesis , 2011, British Journal of Cancer.

[7]  Janet Rossant,et al.  The Crumbs complex couples cell density sensing to Hippo-dependent control of the TGF-β-SMAD pathway. , 2010, Developmental cell.

[8]  Juergen A. Knoblich,et al.  Asymmetric cell division: recent developments and their implications for tumour biology , 2010, Nature Reviews Molecular Cell Biology.

[9]  Xuebing Ding,et al.  TGF-β-induced MiR-491-5p Expression Promotes Par-3 Degradation in Rat Proximal Tubular Epithelial Cells* , 2010, The Journal of Biological Chemistry.

[10]  B. Woda,et al.  Loss of cell polarity protein Lgl2 in foveolar-type gastric dysplasia: correlation with expression of the apical marker aPKC-zeta , 2010, Virchows Archiv.

[11]  R. Karlsson,et al.  Rac1 is crucial for Ras-dependent skin tumor formation by controlling Pak1-Mek-Erk hyperactivation and hyperproliferation in vivo , 2010, Oncogene.

[12]  Juan Huang,et al.  The apical transmembrane protein Crumbs functions as a tumor suppressor that regulates Hippo signaling by binding to Expanded , 2010, Proceedings of the National Academy of Sciences.

[13]  D. St Johnston,et al.  aPKC Phosphorylation of Bazooka Defines the Apical/Lateral Border in Drosophila Epithelial Cells , 2010, Cell.

[14]  Jarema Malicki,et al.  The Apical Complex Couples Cell Fate and Cell Survival to Cerebral Cortical Development , 2010, Neuron.

[15]  A. Pession,et al.  The lethal giant larvae tumour suppressor mutation requires dMyc oncoprotein to promote clonal malignancy , 2010, BMC Biology.

[16]  B. Zhou,et al.  Snail: More than EMT. , 2010, Cell adhesion & migration.

[17]  G. Browne,et al.  ZEB proteins link cell motility with cell cycle control and cell survival in cancer , 2010, Cell cycle.

[18]  Y. Wu,et al.  TNF-α/NF-κB/Snail pathway in cancer cell migration and invasion , 2010, British Journal of Cancer.

[19]  J. C. Pastor-Pareja,et al.  Interaction between RasV12 and scribble clones induces tumour growth and invasion , 2009, Nature.

[20]  Lu Dan,et al.  hScrib, a human homolog of Drosophila neoplastic tumor suppressor, is involved in the progress of endometrial cancer. , 2009, Oncology research.

[21]  C. Nüsslein-Volhard,et al.  Lgl2 Executes Its Function as a Tumor Suppressor by Regulating ErbB Signaling in the Zebrafish Epidermis , 2009, PLoS genetics.

[22]  A. Fields,et al.  Atypical protein kinase C{iota} is required for bronchioalveolar stem cell expansion and lung tumorigenesis. , 2009, Cancer research.

[23]  J. Moffat,et al.  A role for the TGFβ-Par6 polarity pathway in breast cancer progression , 2009, Proceedings of the National Academy of Sciences.

[24]  M Taniwaki,et al.  Defective expression of polarity protein PAR-3 gene (PARD3) in esophageal squamous cell carcinoma , 2009, Oncogene.

[25]  Y. Jan,et al.  Mammalian Par3 Regulates Progenitor Cell Asymmetric Division via Notch Signaling in the Developing Neocortex , 2009, Neuron.

[26]  A. Suzuki,et al.  Interaction between PAR-3 and the aPKC–PAR-6 complex is indispensable for apical domain development of epithelial cells , 2009, Journal of Cell Science.

[27]  B. Woda,et al.  Cell polarity protein Lgl2 is lost or aberrantly localized in gastric dysplasia and adenocarcinoma: an immunohistochemical study , 2009, Modern Pathology.

[28]  J. Pollard,et al.  Microenvironmental regulation of metastasis , 2009, Nature Reviews Cancer.

[29]  A. Ridley,et al.  Phosphoinositide 3‐kinases in cell migration , 2009, Biology of the cell.

[30]  Z. Xuan,et al.  Deregulation of Scribble Promotes Mammary Tumorigenesis and Reveals a Role for Cell Polarity in Carcinoma , 2008, Cell.

[31]  R. Javier.  Cell polarity proteins: common targets for tumorigenic human viruses , 2008, Oncogene.

[32]  John G. Collard,et al.  Crosstalk between small GTPases and polarity proteins in cell polarization , 2008, Nature Reviews Molecular Cell Biology.

[33]  Marissa E. Nolan,et al.  The polarity protein Par6 induces cell proliferation and is overexpressed in breast cancer. , 2008, Cancer research.

[34]  T. Dønnem,et al.  The prognostic impact of NF-κB p105, vimentin, E-cadherin and Par6 expression in epithelial and stromal compartment in non-small-cell lung cancer , 2008, British Journal of Cancer.

[35]  H. Richardson,et al.  Loss of human Scribble cooperates with H-Ras to promote cell invasion through deregulation of MAPK signalling , 2008, Oncogene.

[36]  J. Visvader,et al.  Cancer stem cells in solid tumours: accumulating evidence and unresolved questions , 2008, Nature Reviews Cancer.

[37]  Yuetsu Tanaka,et al.  Human T-cell leukemia virus type 1 Tax induces an aberrant clustering of the tumor suppressor Scribble through the PDZ domain-binding motif dependent and independent interaction , 2008, Virus Genes.

[38]  E. Fearon,et al.  The transcription factor snail represses Crumbs3 expression and disrupts apico-basal polarity complexes , 2008, Oncogene.

[39]  T. Ishikawa,et al.  The overexpression and altered localization of the atypical protein kinase C lambda/iota in breast cancer correlates with the pathologic type of these tumors. , 2008, Human pathology.

[40]  E. White,et al.  Role of the polarity determinant crumbs in suppressing mammalian epithelial tumor progression. , 2008, Cancer research.

[41]  A. Le Bivic,et al.  Polarity complex proteins. , 2008, Biochimica et biophysica acta.

[42]  J. Knoblich,et al.  Mechanisms of Asymmetric Stem Cell Division , 2008, Cell.

[43]  K. Kaibuchi,et al.  Rho-kinase phosphorylates PAR-3 and disrupts PAR complex formation. , 2008, Developmental cell.

[44]  A. Dimmler,et al.  The transcriptional repressor ZEB1 promotes metastasis and loss of cell polarity in cancer. , 2008, Cancer research.

[45]  M. R. Costa,et al.  Par-complex proteins promote proliferative progenitor divisions in the developing mouse cerebral cortex , 2007, Development.

[46]  J. Mesnard,et al.  The PDZ Domain-binding Motif of the Human T Cell Leukemia Virus Type 1 Tax Protein Induces Mislocalization of the Tumor Suppressor hScrib in T cells* , 2007, Journal of Biological Chemistry.

[47]  R. Foisner,et al.  The transcription factor ZEB1 (δEF1) promotes tumour cell dedifferentiation by repressing master regulators of epithelial polarity , 2007, Oncogene.

[48]  John G. Collard,et al.  The Par-Tiam1 Complex Controls Persistent Migration by Stabilizing Microtubule-Dependent Front-Rear Polarity , 2007, Current Biology.

[49]  G. Collina,et al.  aPKCζ cortical loading is associated with Lgl cytoplasmic release and tumor growth in Drosophila and human epithelia , 2007, Oncogene.

[50]  Héctor Peinado,et al.  Snail, Zeb and bHLH factors in tumour progression: an alliance against the epithelial phenotype? , 2007, Nature Reviews Cancer.

[51]  O. Rath,et al.  MAP kinase signalling pathways in cancer , 2007, Oncogene.

[52]  K. Kaibuchi,et al.  Neuronal polarity: from extracellular signals to intracellular mechanisms , 2007, Nature Reviews Neuroscience.

[53]  S. Silverstein,et al.  PATJ, a Tight Junction-Associated PDZ Protein, Is a Novel Degradation Target of High-Risk Human Papillomavirus E6 and the Alternatively Spliced Isoform 18 E6* , 2007, Journal of Virology.

[54]  Matthew F Krummel,et al.  Maintenance and modulation of T cell polarity , 2006, Nature Immunology.

[55]  Kozo Kaibuchi,et al.  Molecular Mechanisms of Axon Specification and Neuronal Disorders , 2006, Annals of the New York Academy of Sciences.

[56]  B. Margolis,et al.  Tight junctions and cell polarity. , 2006, Annual review of cell and developmental biology.

[57]  L. Banks,et al.  Human discs large and scrib are localized at the same regions in colon mucosa and changes in their expression patterns are correlated with loss of tissue architecture during malignant progression , 2006, International journal of cancer.

[58]  A. Bosserhoff,et al.  Expression of Dickkopf genes is strongly reduced in malignant melanoma , 2006, Oncogene.

[59]  T. Noda,et al.  PAR3 is essential for cyst-mediated epicardial development by establishing apical cortical domains , 2006, Development.

[60]  M. Bissell,et al.  Of extracellular matrix, scaffolds, and signaling: tissue architecture regulates development, homeostasis, and cancer. , 2006, Annual review of cell and developmental biology.

[61]  A. Bosserhoff,et al.  Expression of Hugl-1 is strongly reduced in malignant melanoma , 2006, Oncogene.

[62]  C. Lohse,et al.  Atypical protein kinase Cι is an oncogene in human non-small cell lung cancer , 2005 .

[63]  John G. Collard,et al.  The Rac activator Tiam1 controls tight junction biogenesis in keratinocytes through binding to and activation of the Par polarity complex , 2005, The Journal of cell biology.

[64]  Miranda Thomas,et al.  The hScrib/Dlg apico-basal control complex is differentially targeted by HPV-16 and HPV-18 E6 proteins , 2005, Oncogene.

[65]  A. Le Bivic,et al.  PATJ connects and stabilizes apical and lateral components of tight junctions in human intestinal cells , 2005, Journal of Cell Science.

[66]  Gordon B Mills,et al.  Atypical PKCiota contributes to poor prognosis through loss of apical-basal polarity and cyclin E overexpression in ovarian cancer. , 2005, Proceedings of the National Academy of Sciences of the United States of America.

[67]  A. Bosserhoff,et al.  Reduced expression of Hugl-1, the human homologue of Drosophila tumour suppressor gene lgl, contributes to progression of colorectal cancer , 2005, Oncogene.

[68]  B. Clurman,et al.  Cyclin E in normal and neoplastic cell cycles , 2005, Oncogene.

[69]  Yue Zhang,et al.  Regulation of the Polarity Protein Par6 by TGFß Receptors Controls Epithelial Cell Plasticity , 2005, Science.

[70]  M. Hoshino,et al.  PAR-6–PAR-3 mediates Cdc42-induced Rac activation through the Rac GEFs STEF/Tiam1 , 2005, Nature Cell Biology.

[71]  B. Margolis,et al.  PATJ regulates tight junction formation and polarity in mammalian epithelial cells , 2005, The Journal of cell biology.

[72]  I. Macara,et al.  Par-3 controls tight junction assembly through the Rac exchange factor Tiam1 , 2005, Nature Cell Biology.

[73]  E. Laurenti,et al.  The human protein Hugl-1 substitutes for Drosophila Lethal giant larvae tumour suppressor function in vivo , 2004, Oncogene.

[74]  K. Prehoda,et al.  Internal recognition through PDZ domain plasticity in the Par-6–Pals1 complex , 2004, Nature Structural &Molecular Biology.

[75]  L. Banks,et al.  Differential expression of the human homologue of drosophila discs large oncosuppressor in histologic samples from human papillomavirus–associated lesions as a marker for progression to malignancy , 2004, International journal of cancer.

[76]  M. Diaz-Meco,et al.  DaPKC-dependent phosphorylation of Crumbs is required for epithelial cell polarity in Drosophila , 2004, The Journal of cell biology.

[77]  Samuel W Straight,et al.  Loss of PALS1 expression leads to tight junction and polarity defects. , 2004, Molecular biology of the cell.

[78]  S. Tapscott,et al.  Loss of cell polarity causes severe brain dysplasia in Lgl1 knockout mice. , 2004, Genes & development.

[79]  Y. Taketani,et al.  Analysis of the expression and localisation of a LAP protein, human scribble, in the normal and neoplastic epithelium of uterine cervix , 2004, British Journal of Cancer.

[80]  H. Richardson,et al.  scribble mutants cooperate with oncogenic Ras or Notch to cause neoplastic overgrowth in Drosophila , 2003, The EMBO journal.

[81]  W. Nelson,et al.  Adaptation of core mechanisms to generate cell polarity , 2003, Nature.

[82]  T. Pawson,et al.  A polarity complex of mPar-6 and atypical PKC binds, phosphorylates and regulates mammalian Lgl , 2003, Nature Cell Biology.

[83]  K. Mechtler,et al.  The Par complex directs asymmetric cell division by phosphorylating the cytoskeletal protein Lgl , 2003, Nature.

[84]  John G. Collard,et al.  Mice deficient in the Rac activator Tiam1 are resistant to Ras-induced skin tumours , 2002, Nature.

[85]  Y. Nagai,et al.  PAR‐6 regulates aPKC activity in a novel way and mediates cell‐cell contact‐induced formation of the epithelial junctional complex , 2001, Genes to cells : devoted to molecular & cellular mechanisms.

[86]  J. Huibregtse,et al.  Human Scribble (Vartul) Is Targeted for Ubiquitin-Mediated Degradation by the High-Risk Papillomavirus E6 Proteins and the E6AP Ubiquitin-Protein Ligase , 2000, Molecular and Cellular Biology.

[87]  P. Aspenström,et al.  The mammalian homologue of the Caenorhabditis elegans polarity protein PAR-6 is a binding partner for the Rho GTPases Cdc42 and Rac1. , 2000, Journal of cell science.

[88]  Haigen Huang,et al.  Stimulation of erythropoiesis by inhibiting a new hematopoietic death receptor in transgenic zebrafish , 2000, Nature Cell Biology.

[89]  T. Pawson,et al.  A mammalian PAR-3–PAR-6 complex implicated in Cdc42/Rac1 and aPKC signalling and cell polarity , 2000, Nature Cell Biology.

[90]  D Bilder,et al.  Cooperative regulation of cell polarity and growth by Drosophila tumor suppressors. , 2000, Science.

[91]  T. Akiyama,et al.  Tax oncoprotein of HTLV-1 binds to the human homologue of Drosophila discs large tumor suppressor protein, hDLG, and perturbs its function in cell growth control , 1999, Oncogene.

[92]  L. Banks,et al.  Oncogenic human papillomavirus E6 proteins target the discs large tumour suppressor for proteasome-mediated degradation , 1999, Oncogene.

[93]  H. Bellen,et al.  Discs Lost, a Novel Multi-PDZ Domain Protein, Establishes and Maintains Epithelial Polarity , 1999, Cell.

[94]  S. S. Lee,et al.  Binding of human virus oncoproteins to hDlg/SAP97, a mammalian homolog of the Drosophila discs large tumor suppressor protein. , 1997, Proceedings of the National Academy of Sciences of the United States of America.

[95]  U. Tepass,et al.  Crumbs and stardust act in a genetic pathway that controls the organization of epithelia in Drosophila melanogaster. , 1993, Developmental biology.

[96]  U. Tepass,et al.  crumbs encodes an EGF-like protein expressed on apical membranes of Drosophila epithelial cells and required for organization of epithelia , 1990, Cell.

[97]  D. Morton,et al.  Identification of genes required for cytoplasmic localization in early C. elegans embryos , 1988, Cell.

[98]  E. Gateff.  Malignant neoplasms of genetic origin in Drosophila melanogaster. , 1978, Science.

[99]  P. Brennwald,et al.  Epithelial and Mesenchymal Cell Biology Tumor Suppressor Scribble Regulates Assembly of Tight Junctions in the Intestinal Epithelium , 2010 .

[100]  W. Liu,et al.  Downregulation of Par-3 expression and disruption of Par complex integrity by TGF-beta during the process of epithelial to mesenchymal transition in rat proximal epithelial cells. , 2008, Biochimica et biophysica acta.

[101]  J. Downward.  Targeting RAS signalling pathways in cancer therapy , 2003, Nature Reviews Cancer.