Neural correlate of subjective sensory experience gradually builds up across cortical areas

When a sensory stimulus is presented, many cortical areas are activated, but how does the representation of a sensory stimulus evolve in time and across cortical areas during a perceptual judgment? We investigated this question by analyzing the responses from single neurons, recorded in several cortical areas of parietal and frontal lobes, while trained monkeys reported the presence or absence of a mechanical vibration of varying amplitude applied to the skin of one fingertip. Here we show that the strength of the covariations between neuronal activity and perceptual judgments progressively increases across cortical areas as the activity is transmitted from the primary somatosensory cortex to the premotor areas of the frontal lobe. This finding suggests that the neuronal correlates of subjective sensory experience gradually build up across somatosensory areas of the parietal lobe and premotor cortices of the frontal lobe.

[1]  D. M. Green,et al.  Signal detection theory and psychophysics , 1966 .

[2]  Mortimer Mishkin,et al.  Analogous neural models for tactual and visual learning , 1979, Neuropsychologia.

[3]  C. Robinson,et al.  Organization of somatosensory receptive fields in cortical areas 7b, retroinsula, postauditory and granular insula of M. fascicularis , 1980, The Journal of comparative neurology.

[4]  P. Goldman-Rakic,et al.  Mnemonic coding of visual space in the monkey's dorsolateral prefrontal cortex. , 1989, Journal of neurophysiology.

[5]  F. A. Seiler,et al.  Numerical Recipes in C: The Art of Scientific Computing , 1989 .

[6]  K. H. Britten,et al.  Neuronal correlates of a perceptual decision , 1989, Nature.

[7]  William H. Press,et al.  Numerical recipes in C (2nd ed.): the art of scientific computing , 1992 .

[8]  William H. Press,et al.  The Art of Scientific Computing Second Edition , 1998 .

[9]  M N Shadlen,et al.  Motion perception: seeing and deciding. , 1996, Proceedings of the National Academy of Sciences of the United States of America.

[10]  N. Logothetis,et al.  Activity changes in early visual cortex reflect monkeys' percepts during binocular rivalry , 1996, Nature.

[11]  K. H. Britten,et al.  A relationship between behavioral choice and the visual responses of neurons in macaque MT , 1996, Visual Neuroscience.

[12]  A. Parker,et al.  Sense and the single neuron: probing the physiology of perception. , 1998, Annual review of neuroscience.

[13]  R. Romo,et al.  Somatosensory discrimination based on cortical microstimulation , 1998, Nature.

[14]  R. Romo,et al.  Neuronal correlates of parametric working memory in the prefrontal cortex , 1999, Nature.

[15]  Jeffrey D. Schall,et al.  The detection of visual signals by macaque frontal eye field during masking , 1999, Nature Neuroscience.

[16]  R. Romo,et al.  Sensing without Touching Psychophysical Performance Based on Cortical Microstimulation , 2000, Neuron.

[17]  D. Heeger,et al.  Activity in primary visual cortex predicts performance in a visual detection task , 2000, Nature Neuroscience.

[18]  J. Schall,et al.  Antecedents and correlates of visual detection and awareness in macaque prefrontal cortex , 2000, Vision Research.

[19]  R. Romo,et al.  Neuronal correlates of sensory discrimination in the somatosensory cortex. , 2000, Proceedings of the National Academy of Sciences of the United States of America.

[20]  R. Romo,et al.  Periodicity and Firing Rate As Candidate Neural Codes for the Frequency of Vibrotactile Stimuli , 2000, The Journal of Neuroscience.

[21]  Jared Rutter,et al.  Regulation of Clock and NPAS2 DNA Binding by the Redox State of NAD Cofactors , 2001, Science.

[22]  Christos Constantinidis,et al.  The sensory nature of mnemonic representation in the primate prefrontal cortex , 2001, Nature Neuroscience.

[23]  R. Romo,et al.  Touch and go: decision-making mechanisms in somatosensation. , 2001, Annual review of neuroscience.

[24]  Á. Pascual-Leone,et al.  Fast Backprojections from the Motion to the Primary Visual Area Necessary for Visual Awareness , 2001, Science.

[25]  Jeffrey D. Schall,et al.  Neural basis of deciding, choosing and acting , 2001, Nature Reviews Neuroscience.

[26]  John H. R. Maunsell,et al.  Dynamics of neuronal responses in macaque MT and VIP during motion detection , 2002, Nature Neuroscience.

[27]  R. Romo,et al.  Temporal Evolution of a Decision-Making Process in Medial Premotor Cortex , 2002, Neuron.

[28]  R. Romo,et al.  Neuronal correlates of decision-making in secondary somatosensory cortex , 2002, Nature Neuroscience.

[29]  Emilio Salinas,et al.  Cognitive neuroscience: Flutter Discrimination: neural codes, perception, memory and decision making , 2003, Nature Reviews Neuroscience.

[30]  S. Blakemore.  Re-uniting philosophy and neuroscience , 2003, Nature Neuroscience.

[31]  R. Romo,et al.  Timing and neural encoding of somatosensory parametric working memory in macaque prefrontal cortex. , 2003, Cerebral cortex.

[32]  R. Romo,et al.  Correlated Neuronal Discharges that Increase Coding Efficiency during Perceptual Discrimination , 2003, Neuron.

[33]  David J. Heeger,et al.  Neuronal correlates of perception in early visual cortex , 2003, Nature Neuroscience.

[34]  Jeffrey D. Schall,et al.  Relationship of presaccadic activity in frontal eye field and supplementary eye field to saccade initiation in macaque: Poisson spike train analysis , 2004, Experimental Brain Research.

[35]  R. Romo,et al.  Neuronal Correlates of a Perceptual Decision in Ventral Premotor Cortex , 2004, Neuron.

[36]  R. Romo,et al.  Neural codes for perceptual discrimination in primary somatosensory cortex , 2005, Nature Neuroscience.

[37]  R. Romo,et al.  Neuronal correlates of subjective sensory experience , 2005, Nature Neuroscience.

[38]  Timothy D. Hanks,et al.  Microstimulation of macaque area LIP affects decision-making in a motion discrimination task , 2006, Nature Neuroscience.