Polyunsaturated fatty acids inhibit stimulated coupling between the ER Ca(2+) sensor STIM1 and the Ca(2+) channel protein Orai1 in a process that correlates with inhibition of stimulated STIM1 oligomerization.

[1]  R. Chapkin,et al.  Alteration of EGFR Spatiotemporal Dynamics Suppresses Signal Transduction , 2012, PloS one.

[2]  B. Baird,et al.  Spatiotemporal resolution of mast cell granule exocytosis reveals correlation with Ca2+ wave initiation , 2012, Journal of Cell Science.

[3]  Deepti Gadi,et al.  Roles for Ca2+ Mobilization and Its Regulation in Mast Cell Functions , 2012, Front. Immun..

[4]  X. Yang,et al.  Structural and mechanistic insights into the activation of Stromal interaction molecule 1 (STIM1) , 2012, Proceedings of the National Academy of Sciences.

[5]  S. Kridel,et al.  Polyunsaturated fatty acid metabolism in prostate cancer , 2011, Cancer and Metastasis Reviews.

[6]  Yongxin Zhao,et al.  An Expanded Palette of Genetically Encoded Ca2+ Indicators , 2011, Science.

[7]  B. Baird,et al.  Stimulated association of STIM1 and Orai1 is regulated by the balance of PtdIns(4,5)P2 between distinct membrane pools , 2011, Journal of Cell Science.

[8]  P. Várnai,et al.  Activation of STIM1-Orai1 Involves an Intramolecular Switching Mechanism , 2010, Science Signaling.

[9]  Deepti Gadi,et al.  Sphingosine derivatives inhibit cell signaling by electrostatically neutralizing polyphosphoinositides at the plasma membrane. , 2010, Self/nonself.

[10]  Sreekanth H. Chalasani,et al.  Imaging neural activity in worms, flies and mice with improved GCaMP calcium indicators , 2009, Nature Methods.

[11]  L. Hunyady,et al.  Visualization and Manipulation of Plasma Membrane-Endoplasmic Reticulum Contact Sites Indicates the Presence of Additional Molecular Components within the STIM1-Orai1 Complex*♦ , 2007, Journal of Biological Chemistry.

[12]  Tobias Meyer,et al.  Live-cell imaging reveals sequential oligomerization and local plasma membrane targeting of stromal interaction molecule 1 after Ca2+ store depletion , 2007, Proceedings of the National Academy of Sciences.

[13]  S. Shaikh,et al.  Polyunsaturated fatty acids, membrane organization, T cells, and antigen presentation. , 2006, The American journal of clinical nutrition.

[14]  P. Sengupta,et al.  Lipid segregation and IgE receptor signaling: a decade of progress. , 2005, Biochimica et biophysica acta.

[15]  B. Baird,et al.  Transmembrane Sequences Are Determinants of Immunoreceptor Signaling 1 , 2005, The Journal of Immunology.

[16]  B. Baird,et al.  Reconstitution of Regulated Phosphorylation of FcϵRI by a Lipid Raft-excluded Protein-tyrosine Phosphatase* , 2005, Journal of Biological Chemistry.

[17]  W. Waldhäusl,et al.  LAT Displacement from Lipid Rafts as a Molecular Mechanism for the Inhibition of T Cell Signaling by Polyunsaturated Fatty Acids* , 2002, The Journal of Biological Chemistry.

[18]  B. Baird,et al.  FcϵRI as a paradigm for a lipid raft-dependent receptor in hematopoietic cells , 2001 .

[19]  L. Samelson,et al.  LAT Is Essential for FcεRI-Mediated Mast Cell Activation , 2000 .

[20]  B. Baird,et al.  Critical Role for Cholesterol in Lyn-mediated Tyrosine Phosphorylation of FcεRI and Their Association with Detergent-resistant Membranes , 1999, The Journal of cell biology.

[21]  J. Zhang,et al.  Transfection of Syk protein tyrosine kinase reconstitutes high affinity IgE receptor-mediated degranulation in a Syk-negative variant of rat basophilic leukemia RBL-2H3 cells , 1996, The Journal of experimental medicine.

[22]  B. Baird,et al.  Heterologous desensitization of the high affinity receptor for IgE (Fc epsilon R1) on RBL cells. , 1993, Journal of immunology.

[23]  D. Conrad,et al.  Aggregation of IgE-receptor complexes on rat basophilic leukemia cells does not change the intrinsic affinity but can alter the kinetics of the ligand-IgE interaction. , 1992, Biochemistry.

[24]  A. Kleinfeld,et al.  Short term exposure to cis unsaturated free fatty acids inhibits degranulation of cytotoxic T lymphocytes. , 1990, Journal of immunology.

[25]  J. Kinet,et al.  Molecular clustering of STIM1 with Orai1/CRACM1 at the plasma membrane depends dynamically on depletion of Ca2+ stores and on electrostatic interactions. , 2009, Molecular biology of the cell.

[26]  J. Billingsley,et al.  Defective mast cell effector functions in mice lacking the CRACM1 pore subunit of store-operated calcium release–activated calcium channels , 2008, Nature Immunology.

[27]  P. Sengupta,et al.  Structural determinants for partitioning of lipids and proteins between coexisting fluid phases in giant plasma membrane vesicles. , 2008, Biochimica et biophysica acta.

[28]  B. Baird,et al.  Reconstitution of regulated phosphorylation of FcepsilonRI by a lipid raft-excluded protein-tyrosine phosphatase. , 2005, The Journal of biological chemistry.

[29]  B. Baird,et al.  Fc(epsilon)RI as a paradigm for a lipid raft-dependent receptor in hematopoietic cells. , 2001, Seminars in immunology.

[30]  L. Samelson,et al.  LAT is essential for Fc(epsilon)RI-mediated mast cell activation. , 2000, Immunity.