Dairy foods and bone health: examination of the evidence.

It is unclear whether dairy foods promote bone health in all populations and whether all dairy foods are equally beneficial. The objective of this review was to determine whether scientific evidence supports the recommendation that dairy foods be consumed daily for improved bone health in the general US population. Studies were reviewed that examined the relation of dairy foods to bone health in all age, sex, and race groups. Outcomes were classified according to the strength of the evidence by using a priori guidelines and were categorized as favorable, unfavorable, or not statistically significant. Of 57 outcomes of the effects of dairy foods on bone health, 53% were not significant, 42% were favorable, and 5% were unfavorable. Of 21 stronger-evidence studies, 57% were not significant, 29% were favorable, and 14% were unfavorable. The overall ratio of favorable to unfavorable effects in the stronger studies was 2.0 (4.0 in <30-y-olds, 1.0 in 30-50-y-olds, and 1.0 in >50-y-olds). Males and ethnic minorities were severely underrepresented. Dairy foods varied widely in their content of nutrients known to affect calcium excretion and skeletal mass. Foods such as milk and yogurt are likely to be beneficial; others, such as cottage cheese, may adversely affect bone health. Of the few stronger-evidence studies of dairy foods and bone health, most had outcomes that were not significant. However, white women <30 y old are most likely to benefit. There are too few studies in males and minority ethnic groups to determine whether dairy foods promote bone health in most of the US population.

[1]  H Boeing,et al.  Validation of a self-administered food-frequency questionnaire administered in the European Prospective Investigation into Cancer and Nutrition (EPIC) Study: comparison of energy, protein, and macronutrient intakes estimated with the doubly labeled water, urinary nitrogen, and repeated 24-h dietary , 1999, The American journal of clinical nutrition.

[2]  C. Weaver,et al.  Choices for achieving adequate dietary calcium with a vegetarian diet. , 1999, The American journal of clinical nutrition.

[3]  R. Lyle,et al.  Previous milk consumption is associated with greater bone density in young women. , 1999, The American journal of clinical nutrition.

[4]  D. Kiel,et al.  Potassium, magnesium, and fruit and vegetable intakes are associated with greater bone mineral density in elderly men and women. , 1999, The American journal of clinical nutrition.

[5]  J. Kerstetter,et al.  Changes in bone turnover in young women consuming different levels of dietary protein. , 1999, The Journal of clinical endocrinology and metabolism.

[6]  S. Giannini,et al.  Acute effects of moderate dietary protein restriction in patients with idiopathic hypercalciuria and calcium nephrolithiasis. , 1999, The American journal of clinical nutrition.

[7]  D Feskanich,et al.  Reproducibility and validity of dietary patterns assessed with a food-frequency questionnaire. , 1999, The American journal of clinical nutrition.

[8]  L. Holmberg,et al.  Excessive Dietary Intake of Vitamin A Is Associated with Reduced Bone Mineral Density and Increased Risk for Hip Fracture , 1998, Annals of Internal Medicine.

[9]  J. Furne,et al.  Lactose maldigestion is not an impediment to the intake of 1500 mg calcium daily as dairy products. , 1998, The American journal of clinical nutrition.

[10]  J. Fischer,et al.  Milk consumption in older Americans. , 1998, American journal of public health.

[11]  L. Massey Does excess dietary protein adversely affect bone? Symposium overview. , 1998, The Journal of nutrition.

[12]  L. Turner,et al.  Risk Factors for Hip Fracture Among Southern Older Women , 1998, Southern medical journal.

[13]  R. Heaney Excess dietary protein may not adversely affect bone. , 1998, The Journal of nutrition.

[14]  Y. Suyama,et al.  Dietary protein intake and urinary excretion of calcium: a cross-sectional study in a healthy Japanese population. , 1998, The American journal of clinical nutrition.

[15]  B. Dawson-Hughes,et al.  Nutritional Aspects of Osteoporosis , 1998, Proceedings in the Serono Symposia USA Series.

[16]  R. Honkanen,et al.  Lactose intolerance associated with fractures of weight-bearing bones in Finnish women aged 38-57 years. , 1997, Bone.

[17]  R. Heaney Nutrient effects: discrepancy between data from controlled trials and observational studies. , 1997, Bone.

[18]  M. Barker,et al.  Milk intake and bone mineral acquisition in adolescent girls: randomised, controlled intervention trial , 1997, BMJ.

[19]  M S Calvo,et al.  Prevalence of Low Femoral Bone Density in Older U.S. Adults from NHANES III , 1997, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[20]  K. Kodama,et al.  Risk Factors for Hip Fracture in a Japanese Cohort , 1997, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[21]  D. Reid,et al.  Nutritional influences on bone mineral density: a cross-sectional study in premenopausal women. , 1997, The American journal of clinical nutrition.

[22]  W. Willett,et al.  Milk, dietary calcium, and bone fractures in women: a 12-year prospective study. , 1997, American journal of public health.

[23]  G. Bray,et al.  A clinical trial of the effects of dietary patterns on blood pressure. DASH Collaborative Research Group. , 1997, The New England journal of medicine.

[24]  S. Cummings,et al.  Racial differences in bone density between young adult black and white subjects persist after adjustment for anthropometric, lifestyle, and biochemical differences. , 1997, The Journal of clinical endocrinology and metabolism.

[25]  N. Solomons The effects of dairy products on body composition, bone mineralization, and weight in adolescent girls. , 2009, Nutrition reviews.

[26]  P. Ross,et al.  Anthropometric, lifestyle and menstrual factors influencing size-adjusted bone mineral content in a multiethnic population of premenopausal women. , 1996, The Journal of nutrition.

[27]  J. Hopper,et al.  Retired elite female ballet dancers and nonathletic controls have similar bone mineral density at weightbearing sites , 1996, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[28]  D. Meier,et al.  A prospective study of bone loss in African-American and white women--a clinical research center study. , 1996, The Journal of clinical endocrinology and metabolism.

[29]  M. Uusitupa,et al.  Does lactose intolerance predispose to low bone density? A population-based study of perimenopausal Finnish women. , 1996, Bone.

[30]  L. Holmberg,et al.  Effect of prefracture versus postfracture dietary assessment on hip fracture risk estimates. , 1996, International journal of epidemiology.

[31]  W. Willett,et al.  Protein consumption and bone fractures in women. , 1996, American journal of epidemiology.

[32]  P. Fox,et al.  Cheese: physical, biochemical, and nutritional aspects. , 1996, Advances in food and nutrition research.

[33]  M Fukunaga,et al.  Influence of exercise and degenerative vertebral changes on BMD: a cross-sectional study in Japanese men. , 1996, Gerontology.

[34]  C. Ulrich,et al.  Bone mineral density in mother-daughter pairs: relations to lifetime exercise, lifetime milk consumption, and calcium supplements. , 1996, The American journal of clinical nutrition.

[35]  O. Johnell,et al.  Risk factors for hip fracture in european women: The MEDOS study , 1995 .

[36]  R. Heaney Optimal calcium intake. , 1995, JAMA.

[37]  J. Muthukannan,et al.  The Food Guide Pyramid , 1995 .

[38]  C. la Vecchia,et al.  Calcium, dairy products, and the risk of hip fracture in women in northern Italy. , 1995, Epidemiology.

[39]  V. Matkovic,et al.  Urinary calcium, sodium, and bone mass of young females. , 1995, The American journal of clinical nutrition.

[40]  T. Remer,et al.  Potential renal acid load of foods and its influence on urine pH. , 1995, Journal of the American Dietetic Association.

[41]  Deborah Kerr,et al.  The effects of calcium supplementation (milk powder or tablets) and exercise on bone density in postmenopausal women , 1995, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[42]  W. Willett,et al.  Health implications of Mediterranean diets in light of contemporary knowledge. 1. Plant foods and dairy products. , 1995, The American journal of clinical nutrition.

[43]  A. Hofman,et al.  Physical activity, calcium intake, and bone mineral content in children in The Netherlands. , 1995, Journal of epidemiology and community health.

[44]  G. Chan,et al.  Effects of dairy products on bone and body composition in pubertal girls. , 1995, The Journal of pediatrics.

[45]  Dietary NaCl-restriction prevents the calciuria of KCl-deprivation and blunts the calciuria of KHCO3-deprivation in healthy adults. , 1995, Kidney international.

[46]  R. Heaney Letter to the Editor: Weight‐bearing activity during youth is a more important factor for peak bone mass than calcium intake , 1995, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[47]  G. Sigurdsson,et al.  Relation between calcium intake, grip strength and bone mineral density in the forearms of girls aged 13 and 15 , 1994, Journal of internal medicine.

[48]  E. Barrett-Connor,et al.  Lifetime milk consumption and bone mineral density in older women. , 1994, American journal of public health.

[49]  H C Kemper,et al.  Weight‐bearing activity during youth is a more important factor for peak bone mass than calcium intake , 1994, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[50]  R. Morris,et al.  Improved mineral balance and skeletal metabolism in postmenopausal women treated with potassium bicarbonate. , 1994, The New England journal of medicine.

[51]  T. Remer,et al.  Estimation of the renal net acid excretion by adults consuming diets containing variable amounts of protein. , 1994, The American journal of clinical nutrition.

[52]  K. Khaw,et al.  Milk consumption and bone mineral density in middle aged and elderly women , 1994, BMJ.

[53]  R. Cumming,et al.  Case-control study of risk factors for hip fractures in the elderly. , 1994, American journal of epidemiology.

[54]  E. Barrett-Connor,et al.  Coffee-associated osteoporosis offset by daily milk consumption. The Rancho Bernardo Study. , 1994, JAMA.

[55]  G. Leidig,et al.  Osteoporosis and bone metabolic parameters in dependence upon calcium intake through milk and milk products. , 1993, European journal of clinical nutrition.

[56]  M. Horowitz,et al.  The nature and significance of the relationship between urinary sodium and urinary calcium in women. , 1993, The Journal of nutrition.

[57]  T. Campbell,et al.  Dietary calcium and bone density among middle-aged and elderly women in China. , 1993, The American journal of clinical nutrition.

[58]  H. Valkenburg,et al.  Determinants of bone mineral density and risk factors for osteoporosis in healthy elderly women , 1993, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[59]  C. Shaw An epidemiologic study of osteoporosis in Taiwan. , 1993, Annals of epidemiology.

[60]  S. Cummings,et al.  Factors Associated with Appendicular Bone Mass in Older Women , 1993, Annals of Internal Medicine.

[61]  D. Langleben Reviews, Notes, and Listings: Pulmonary Medicine: The Diagnosis and Treatment of Pulmonary Hypertension , 1993, Annals of Internal Medicine.

[62]  R R Recker,et al.  Bone gain in young adult women. , 1992, JAMA.

[63]  D. Meier,et al.  Racial differences in pre‐ and postmenopausal bone homeostasis: Association with bone density , 1992, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[64]  P. Elwood,et al.  Factors affecting bone density in young adults. , 1992, The American journal of clinical nutrition.

[65]  K. Hirota,et al.  Effect of diet and lifestyle on bone mass in Asian young women. , 1992, The American journal of clinical nutrition.

[66]  S. Cummings,et al.  Risk factors for fractures of the distal forearm and proximal humerus. The Study of Osteoporotic Fractures Research Group. , 1992, American journal of epidemiology.

[67]  John A. Kanis,et al.  Bone and Mineral Research , 1991 .

[68]  B. Henderson,et al.  Exercise and Other Factors in the Prevention of Hip Fracture: The Leisure World Study , 1991, Epidemiology.

[69]  M. V. van Schaik,et al.  Relationship between the calcium-to-protein ratio in milk and the urinary calcium excretion in healthy adults--a controlled crossover study. , 1990, The American journal of clinical nutrition.

[70]  R. Lew,et al.  Dietary modification with dairy products for preventing vertebral bone loss in premenopausal women: a three-year prospective study. , 1990, The Journal of clinical endocrinology and metabolism.

[71]  B. Tilley,et al.  Identification of women at risk for developing postmenopausal osteoporosis with vertebral fractures: role of history and single photon absorptiometry. , 1989, Bone and mineral.

[72]  J. Pleuss,et al.  Potassium bicarbonate, but not sodium bicarbonate, reduces urinary calcium excretion and improves calcium balance in healthy men. , 1989, Kidney international.

[73]  A. Miller,et al.  A study of repeatability of dietary data over a seven-year period. , 1989, American journal of epidemiology.

[74]  J. Kanis,et al.  Calcium supplementation of the diet--II. , 1989, BMJ.

[75]  J. Witschi,et al.  Nonalcoholic carbonated beverage consumption and bone fractures among women former college athletes , 1989, Journal of orthopaedic research : official publication of the Orthopaedic Research Society.

[76]  R. Weinstein,et al.  Diminished rates of bone formation in normal black adults. , 1988, The New England journal of medicine.

[77]  F. Tylavsky,et al.  Dietary factors in bone health of elderly lactoovovegetarian and omnivorous women. , 1988, The American journal of clinical nutrition.

[78]  A. Flynn,et al.  Influence of dietary sodium intake on urinary calcium excretion in selected Irish individuals. , 1988, European journal of clinical nutrition.

[79]  R. Bauer Ethnic differences in hip fracture: a reduced incidence in Mexican Americans. , 1988, American journal of epidemiology.

[80]  G. Chan,et al.  Effects of increased dietary calcium intake upon the calcium and bone mineral status of lactating adolescent and adult women. , 1987, The American journal of clinical nutrition.

[81]  H. Morris,et al.  The problem of calcium requirement. , 1987, The American journal of clinical nutrition.

[82]  J. Wishart,et al.  Lactose and calcium absorption in postmenopausal osteoporosis. , 1987, Archives of internal medicine.

[83]  R. Gasser,et al.  Lactose absorption, milk consumption, and fasting blood glucose concentrations in women with idiopathic osteoporosis. , 1986, British medical journal.

[84]  J. Hankin,et al.  The relationship between diet and bone mineral content of multiple skeletal sites in elderly Japanese-American men and women living in Hawaii. , 1985, The American journal of clinical nutrition.

[85]  R. Recker Reply to letter by Mazess, Harper, and DeLuca , 1985 .

[86]  A. Kriska,et al.  Postmenopausal bone density and milk consumption in childhood and adolescence. , 1985, The American journal of clinical nutrition.

[87]  R. Recker,et al.  The effect of milk supplements on calcium metabolism, bone metabolism and calcium balance. , 1985, The American journal of clinical nutrition.

[88]  K. Sakhaee,et al.  Contrasting effects of potassium citrate and sodium citrate therapies on urinary chemistries and crystallization of stone-forming salts. , 1983, Kidney international.

[89]  G. Block,et al.  A review of validations of dietary assessment methods. , 1982, American journal of epidemiology.

[90]  J. Pennington Bowes' and Church's Food Values of Portions Commonly Used , 1980 .